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Silver, P. B., Horai, R., Chen, J., Jittayasothorn, Y., Chan, C. C., Villasmil, R., Kesen, M. R. and Caspi, R. R. (2015). Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis. J Immunol 194(7): 3011-3019.
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Chong, W. P., van Panhuys, N., Chen, J., Silver, P. B., Jittayasothorn, Y., Mattapallil, M. J., Germain, R. N. and Caspi, R. R. (2015). NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-gamma-IL-27 axis. J Exp Med 212(10): 1739-1752.
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Horai, R., Zarate-Blades, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C. C., Yamane, H., Honda, K. and Caspi, R. R. (2015). Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity 43(2): 343-353.
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Horai, R., Silver, P. B., Chen, J., Agarwal, R. K., Chong, W. P., Jittayasothorn, Y., Mattapallil, M. J., Nguyen, S., Natarajan, K., Villasmil, R., Wang, P., Karabekian, Z., Lytton, S. D., Chan, C. C. and Caspi, R. R. (2013). Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen. J Autoimmun 44: 21-33.
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Zhou, R., Horai, R., Silver, P. B., Mattapallil, M. J., Zarate-Blades, C. R., Chong, W. P., Chen, J., Rigden, R. C., Villasmil, R. and Caspi, R. R. (2012). The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol 188(4): 1742-1750.
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Zhou, R., Horai, R., Mattapallil, M. J. and Caspi, R. R. (2011). A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid. J Immunol 187(8): 4170-4177.
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Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C. C. and Caspi, R. R. (2008). Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med 205(4): 799-810.
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Tang, J., Zhu, W., Silver, P. B., Su, S. B., Chan, C. C. and Caspi, R. R. (2007). Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signature and is driven by unique effector mechanisms: initial encounter with autoantigen defines disease phenotype. J Immunol 178(9): 5578-5587.
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Silver, P. B., Agarwal, R. K., Su, S. B., Suffia, I., Grajewski, R. S., Luger, D., Chan, C. C., Mahdi, R. M., Nickerson, J. M. and Caspi, R. R. (2007). Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J Immunol 179(8): 5146-5158.
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Grajewski, R. S., Silver, P. B., Agarwal, R. K., Su, S. B., Chan, C. C., Liou, G. I. and Caspi, R. R. (2006). Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med 203(4): 851-856.
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Pennesi, G., Mattapallil, M. J., Sun, S. H., Avichezer, D., Silver, P. B., Karabekian, Z., David, C. S., Hargrave, P. A., McDowell, J. H., Smith, W. C., Wiggert, B., Donoso, L. A., Chan, C. C. and Caspi, R. R. (2003). A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest 111(8): 1171-1180.
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Avichezer, D., Grajewski, R. S., Chan, C. C., Mattapallil, M. J., Silver, P. B., Raber, J. A., Liou, G. I., Wiggert, B., Lewis, G. M., Donoso, L. A. and Caspi, R. R. (2003). An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med 198(11): 1665-1676.
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Agarwal, R. K., Kang, Y., Zambidis, E., Scott, D. W., Chan, C. C. and Caspi, R. R. (2000). Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest 106(2): 245-252.
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Xu, H., Wawrousek, E. F., Redmond, T. M., Nickerson, J. M., Wiggert, B., Chan, C. C. and Caspi, R. R. (2000). Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol 30(1): 272-278.
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Tarrant, T. K., Silver, P. B., Wahlsten, J. L., Rizzo, L. V., Chan, C. C., Wiggert, B. and Caspi, R. R. (1999). Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. J Exp Med 189(2): 219-230.
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Jones, L. S., Rizzo, L. V., Agarwal, R. K., Tarrant, T. K., Chan, C. C., Wiggert, B. and Caspi, R. R. (1997). IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response. J Immunol 158(12): 5997-6005.
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Rizzo, L. V., Miller-Rivero, N. E., Chan, C. C., Wiggert, B., Nussenblatt, R. B. and Caspi, R. R. (1994). Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Invest 94(4): 1668-1672.
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Caspi, R. R., Roberge, F. G., Chan, C. C., Wiggert, B., Chader, G. J., Rozenszajn, L. A., Lando, Z. and Nussenblatt, R. B. (1988). A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol 140(5): 1490-1495.
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Caspi, R. R., Roberge, F. G. and Nussenblatt, R. B. (1987). Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes. Science 237(4818): 1029-1032.