联合评审(
Fanglian He Bio-protocol
205 protocols

Jyotiska Chaudhuri Baxter Healthcare Corporation
28 protocols

Kristin L. Shingler University of Minnesota School of Dentistry
29 protocols

Michael Enos University of Texas Southwestern Medical Center
19 protocols

编委
Peichuan Zhang
  • Research scientist, Acepodia Biotech
研究方向
  • 分子生物学
  • Aging, molecular genetics, C. elegans, high-throughput small-molecule screen, siRNA screen
  • 已发表 protocol 5

教育背景

PhD, Pennsylvania State University, 2003

发表论文

1) Zhang, P., Zhai, Y., Cregg, J., Ang, K.K, Arkin, M. and Kenyon, C. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. G3 (Bethesda). 2020. 10:849-62.

2) Mack, H.I.D., Zhang, P., Fonslow, B.R., and Yates, J.R. The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans. Aging (Albany NY). 2017. [Epub ahead of print]

3) Zhang, P., Judy, M., Lee, S.J., and Kenyon, C. Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metabolism. 2013. 17:85-100.

4) Henis-Korenblit, S., Zhang, P., Hansen, M., McCormick, M., Lee, S.J., Cary, M., and Kenyon, C. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010. 107:9730-5.

5) Yamawaki, T.M., Arantes-Oliveira, N., Berman, J.R., Zhang, P., and Kenyon, C. Independent activities of the germline and somatic reproductive tissues in the regulation of C. elegans’ lifespan. Genetics. 2008. 178:513-26.
已发表 protocol 5篇
Analysis of Mouse Liver Glycogen Content
小鼠肝糖原含量检测

作者:Peichuan Zhang日期:05/20/2012,浏览量:37256,Q&A: 11
Liver is the major site for glycogen storage. Glycogen content can be significantly altered upon disruption of glucose homeostasis in metabolic syndromes, such as diabetes. Glycogen content can be determined by an acid-hydrolysis method ...
Alcian Blue – Alizarin Red Staining of Mouse Skeleton
阿尔辛蓝 - 茜素红对小鼠骨架染色

作者:Peichuan Zhang日期:04/20/2012,浏览量:29481,Q&A: 9
Our lab has used the Alcian blue – Alizarin red staining method with certain modifications to characterize skeleton deformities in mice lacking Pek/Perk, encoding a translational control eIF2alpha kinase.
参审 protocol 2篇
Chemotaxis and Jumping Assays in Nematodes
线虫趋化性和跳跃运动试验
作者:Tiffany Baiocchi and Adler R. Dillman日期:09/20/2015,浏览量:9212,Q&A: 0
Nematodes have sensitive olfactory perception, which is used to detect and differentiate many volatile odorants. Some odorants are attractive, others repulsive, and yet others evoke no particular response. Chemotaxis assays can be used to determine ...
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Lipid Extraction from Mouse Feces
小鼠排泄物中的脂质提取
作者:Daniel Kraus, Qin Yang and Barbara B. Kahn日期:01/05/2015,浏览量:14749,Q&A: 0
The analysis of feces composition is important for the study of energy metabolism, which comprises various measurements of energy intake, energy expenditure, and energy wasting. The current protocol describes how to measure energy-dense lipids in ...
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主审 protocol 12篇
Infection of Caenorhabditis elegans with Vesicular Stomatitis Virus via Microinjection
水疱性口炎病毒通过显微注射感染秀丽隐杆线虫
作者:Adam Martin, Emily A. Rex, Takao Ishidate, Rueyling Lin and Don B. Gammon日期:11/20/2017,浏览量:6128,Q&A: 0
Over the past 15 years, the free-living nematode, Caenorhabditis elegans has become an important model system for exploring eukaryotic innate immunity to bacterial and fungal pathogens. More recently, infection models using either natural ...
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Superoxide Dismutase (SOD) and Catalase (CAT) Activity Assay Protocols for Caenorhabditis elegans
秀丽隐杆线虫中超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性测定实验方案
作者:Jing Zhang, Rui Chen, Zhenyang Yu and Lili Xue日期:08/20/2017,浏览量:31181,Q&A: 0
Assays for superoxide dismutase (SOD) and catalase (CAT) activities are widely employed to indicate antioxidant responses underlying the toxic effects of test chemicals. Yet, earlier studies mainly described the procedures as performed according to ...
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