Rosario Gomez-Garcia
  • Lab Director, Stanford University School of Medicine
Research focus
  • Biochemistry, Biophysics, Developmental Biology, Immunology, Microbiology
Personal information


pHD, Stanford University, 2001

Research focus

Biochemistry, Polyphosphate, Sensors, Immunology, Cyanobacteria, Synthetic Biology


1. On the Synthesis of Inorganic Polyphosphate in Eukaruotes. Frontiers in Biology, 2020 (submitted for publication)
2. Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation. Seidlmayer LK, Gomez-Garcia MR, Shiba T, Porter GA Jr, Pavlov EV, Bers DM, Dedkova EN. Arch Biochem Biophys. 2019 Feb 15;662:177-189.
3. A Pseudomonas putida Double Mutant Defficient in Butanol Assimilation: A Promissing step for a Biofuel Production Platform. Sol Cuenca, Carlos Molina-Santiago, MR. Gómez-García, Juan Luis Ramos. FEMS Microbiol Lett. 2016 Mar;363(5).
4. Inorganic Polyphosphate: “New Roles for a New Molecule”. MR Gómez-García. Biochemical Journal Review (Accepted)
5. Cuenca, M. d. S., Roca, A., Molina-Santiago, C., Duque, E., Armengaud, J., Gómez-García, M. R. and Ramos, J. L. (2016), Understanding butanol tolerance and assimilation in Pseudomonas putida BIRD-1: an integrated omics approach. Microbial Biotechnology, 9: 100–115. doi:10.1111/1751-7915.12328
6. “Mechanisms of solvent resistance mediated by interplay of cellular factors in Pseudomonas putida”. Ramos, Juan L.; Cuenca, María; Molina-Santiago, Carlos; Segura, Ana; Duque, Estrella; Gómez-García, María; Udaondo, Zulema; Roca, Amalia. FEMS Microbiology Reviews, 2015.
7. “Inorganic Polyphosphate as a novel purinergic receptor activator in both CNS and PNS neurons”. Stephanie C Stotz, Lucas OM Scott, Christopher Drummond-Main, Yosef Avchalumov, Fernando Girotto, Jörn Davidsen, Maria R Gómez-García, Jong M Rho, Evgeny V Pavlov and Michael A Colicos. Molecular Brain 2014, 7:42.
8. The Role of Polyphosphate in Thermophilic Synechococcus sp. From Microbial Mats”. Maria R. Gómez-García*, Fariba Fazeli, Alexandra Grote, A. Grossman, D. Bhaya. J Bacteriol. 2013 Aug;195(15):3309-19
9. “Inorganic polyphosphate is a potent activator of the mitochondrial permeability transition pore in cardiac myocytes under conditions of calcium overload and during ischemia-reperfusion”. Lea K. Seidlmayer, Maria R. Gómez-Garca, Lothar A. Blatter, Evgeny Pavlov, Elena N. Dedkova. 2012, Journal of General Physiology, 139, 321-331
10. “Alternative Pathways for Phosphonate Metabolism in Thermophilic Cyanobacteria from Microbial Mats”. Maria R. Gómez-García*, Michelle Davison, Matthew Blain-Hartnung, Arthur R. Grossman, Devaki Bhaya. ISME J. 2011 Jan; 5(1):141-9.
11. “Inorganic polyphosphate and energy metabolism in mammalian cells”. Evgeny Pavlov, Roozbeh Aschar-Sobbi, Michelangelo Campanella, María R. Gómez-García, and Andrey Y. Abramov. J Biol Chem. 2010 Mar 26;285(13):9420-8
12. “Inorganic Polyphosphate: Essential for Growth and Survival”. N. Rao, MR Gómez-García and A. Kornberg. Annu Rev Biochem. 2009:78:605-47.
13. “Phosphorous deprivation responses and phosphonate utilization in a thermophilic Synechococcus sp. from microbial mats. Melissa Adams, Maria R. Gómez-García, Arthur Grossman, Devaki Bhaya. Journal of Bacteriology. 2008 Dec:190(24):8171-84.
14. “Arthur Kornberg, obituary”. MR Gómez-García. Journal of the Biochemical Spanish Society SEBBM, 154. Dec, 2007
15. “Comparative Biochemical and Functional Studies of Family I Soluble Inorganic Pyrophosphatases from Photosynthetic Bacteria”. MR. Gómez-García*, M. Losada and A. Serrano. FEBS Journal 2007, 274, 3948–3959. Co-corresponding author.
16. “Polyphosphate Kinase 1, a Conserved Bacterial Enzyme, in a Eukaryote, Dictyostelium discoideum, with a Role in Cytokinesis”. H. Zhang, MR Gómez-García, N. N. Rao and Arthur Kornberg. PNAS 2007, 104, 16486-16491.
17. “Inorganic polyphosphate in Dictyostelium discoideum” MR Gómez-García, H. Zhang, N. N. Rao and Arthur Kornberg. The Faseb Journal, (2006), II, 589.4.
18. “A novel subfamily of monomeric inorganic pyrophosphatases in photosynthetic eukaryotes”. Maria R. Gómez-García*, Manuel Losada, Aurelio Serrano. Biochemical Journal, (2006), 395, 211-221. Co-corresponding author.
19. “Role of Inorganic Polyphosphate in sporulation, fruiting body formation and predation in Dictyostelium discoideum” H. Zhang, MR Gómez-García, M. R. Brown and Arthur Kornberg. PNAS (2005), 102, 2731-5.
20. “Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa”. Silvia Orenes Lorente, Maria R. Gómez-García, Carmen Jimenez, Simon Cammerer, Vanessa Yardley, Kate de Luca-Fradley, Simon L. Croft, Luis M. Ruiz Perez, Julio Urbina, Dolores Gonzalez Pacanowska and Ian H. Gilbert (2005) Biorg & Med Chemistry 13, 3519–3529.
21. “Formation of an Actin-like Filament Concurrent with the Enzymatic Synthesis of Inorganic Polyphosphate” M R. Gómez-García, A. Kornberg. PNAS (2004), 101, 15876-15880.
22. “A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major”. Maria R Gómez-García, Luis M Ruiz Perez D. González-Pacanowska and Aurelio Serrano. FEBS Letters (2004), 28105; 1-9.
23. “Concurrent transcriptional activation of ppa and ppx genes by phosphate deprivation in the cyanobacterium Synechocystis sp. strain PCC 6803” MR Gómez-García, M. Losada and Aurelio Serrano. BBRC (2003); 302, 284-292
24. “Expression Studies of two Paralogous ppa Genes Encoding Distinct Family Pyrophosphatases in Marine Unicellular Cyanobacteria Reveal Inactivation of the Typical Cyanobacterial Gene” MR Gómez-García, Aurelio Serrano BBRC (2002), 295, 890-897.
25. “Enzymatic systems of inorganic pyrophosphate bioenergetics in photosynthetic and heterotrophic protists: remains or metabolic cornerstones? Jose R. Pérez-Castiñeira, M. Rosario Gómez-García, Rosa L. López-Marques, Manuel Losada and Aurelio Serrano. International Microbiology 2001 4:135-142.DOI 10.1007/S101123-001-0028-x/

• In: Biología Molecular de Plantas". Dirección General de Investigación Agraria, Conserjería de Agricultura y Pesca. Junta de Andalucía vol 34-95. Pp. 152-153 (1995). ISBN 84-87564-34-8
• In "Inorganic Pyrophosphatases", Univ of Turku press. (R. Lathi, ed.) pp. 6-9 (1997) ISBN 951-29-0990-1
• In" Phototrophic Prokaryotes". (G.A. Perschek, W. Löffelhardt and G. Schmetterer, eds.). Plenum Publishing Corporation, New York (1998). Vol XI 987-876 ISBN 789 0983-2.
• In "V Congreso Hispano-Luso de Fisiología Vegetal". Dirección General de Investigación y Formación Agraria, Conserjería de Agricultura y Pesca. Junta de Andalucía, pp.228-229 (1997) ISBN 84-89802-12-2.
• In" Mechanisms and effects" (G. Garab and J. Pusztai, eds). Kluwer Academic Publishers, Dordrecht (1998) vol V, 3683-3686.
• In "VI Congreso Hispano-Luso de Fisiología Vegetal. Secretariado de Publicaciones de la Universidad de Sevilla, ed. (1999) Pp 145 ISBN84-472-0548-7
• In “Trends in Inorganic Pyrophosphatases research” Univ. of Sevilla (A.Serrano, eds) pp.63-66 (2001) ISBN 84-699-4960-8.


• "Caracterización de los enzimas del metabolismo energético del pirofosfato de microorganismos fotosintéticos y su utilidad como sistemas modelo en Bioenergética". M. R., M. Losada and A. Serrano. III Reunión de Biología Molecular de plantas. 1995 Sevilla. (writen communication).
• "Cyanobacterial soluble inorganic pyrophosphatase: purification, characterization and PCR amplification of the gene". M. R.Gómez, F. Valverde, M. Losada and A. Serrano. Congreso FEBS. 1996. Barcelona. (Writen communication).
• "Cyanobacterial and algal inorganic pyrophosphatases and the molecular phylogeny of the higher plants enzymes". R. Gómez, M. Losada and A. Serrano. First International Meeting on Inorganic Pyrophosphatases. Turku (Finland). 1997. Writen communication.
• "The structural diversity of inorganic pyrophosphatases of photosynthetic microorganisms and the molecular phylogeny of the homologous plastid enzymes". R. Gómez, M. Losada y A. Serrano. International Symposium on Phototrophic Prokaryotes. 1997. Viena (Austria). (Writen communication).
• "Heterogeneidad molecular de las pirofosfatasas inorgánicas de organismos fotosintéticos y su relevancia para la filogenia de los plastidios". R. Gómez, M. Losada y A. Serrano. V Congreso Hispano-luso de Fisiología Vegetal. Córdoba. 1997. Written communication.
• "Structural diversity and functional conservation of soluble inorganic pyrophosphatases of photosynthetic prokaryotes and plastids" R. Gómez, M. Losada and A. Serrano. XIth International Congress on Photosynthesis. Budapest (Hungary) 1998. Written communication.
• "La pirofosfatasa soluble de protistas fotosintéticos: un enzima plastídico estructuralmente distinto a su holmólogo de procariotas fotosinteticos". R. Gómez, M. Losada and A. Serrano. II Reunión del Grupo de Protozoología de la Sociedad Española de Protozoología. Written communication.
• "La pirofosfatasa inorgánica de plástidos fotosintéticcos de microalgas y plantas: relaciones estructurales y funcionales" M.R. Gómez, M. Losada and A. Serrano. VI Congreso Hispano-Luso de Fisiología Vegetal. Written communication.
• “Soluble inorganic pyrophoshatases from photosynthetic prokaryotes and plastids: structural diversity and distinct molecular phylogeny” MR Gómez-García, M Losada and A.Serrano. ISPP 2000. Written communication.
• “On the quimeric nature of the Soluble Pyrophosphatases set from photosynthetic eukaryotes” Second International Meeting on Inorganic Pyrophosphatases. Sevilla, Mayo 2001. Oral communication.
• “El pirofosfato inorgánico, un metabolito clave en la Bioenergética y la homeostasis iónica de los organismos fotosintéticos”. XIV Reunión de la Sociedad española de Fisiología Vegetal y VII Congreso Hispano-Luso. Badajoz September 2001.
• “Studies on the enzymatic systems of inorganic pyrophosphatase and polyphosphate metabolism in Arabidopsis” XIII International Conference on Arabidopsis Research. 2002. Sevilla.
• “Expresión de una forma soluble de escualeno sintasa de Leishmania major” MR. Gómez-García, Aurora Constan-Gutiérrez, Julio A. Urbina, LM. Ruiz-Pérez y D González-Pacanowska 25th Congreso SEBBM 2002-07-02.
• “Metabolismo de esteroles en tripanosomátidos” Jimenez-Jimenez C., Gómez-García MR, Ortiz Gómez A., Ruiz-Pérez LM, González-Pacanowskca D. 25th Congreso SEBBM 2002-07-02
• “New Approaches to Specific Chemotherapy of Chagas disease and Leishmaniassis: Validation of Squalene Synthase as a Chemotherapeutic Target” J. A. Urbina, Dolores González-Pacanowska, Juan Luis Concepción, Gonzalo Visbal, Salome Rangelo, Renee Lira, Aura Caldera, MR. Gómez-García. 5th COST B9 Congress, London. Oral communication.
• “Characterization of Enzymes Involved in Sterol Biosynthesis in Leishmania major” González-Pacanowska, D., Jiménez-Jiménez C., Gómez-García MR, Ortiz-Gómez, A. 5th COST B9 Congress. Oral communication.
• “Enzimas del metabolismo de esteroles como blanco de acción de fármacos” MR. Gómez-García, Mª Carmen Jiménez-Jiménez, Aurora Ortiz-Gómez, Aurora Constan-Gutiérrez, Luis M. Ruiz-Pérez and Dolores González-Pacanowska. IV Congreso de la SEM. Sevilla Sep. 2002.
• “La pirofosfatasa inorgánica soluble de Leishmania major: una enzima distinta a sus homólogas eucariotas” MR. Gómez-García, Luis M. Ruiz-Pérez, D. González-Pacanowska and Aurelio Serrano. Oral communication. IV Congreso SEM. Sevilla Sep. 2002.
• “The Role of Polyphosphate in Thermophilic Synechococcus sp. From Microbial Mats” M.R. Gómez-García, Fariba Fazeli, A. T. Grote, A. Grossman, D. Bhaya. ASM, 2012, San Francisco, USA.
• CAS Conference, Synthetic Biology, 2012, Munich.
• Gordon Research Conference, Synthetic Biology, (Re-)constructing and Re-programming Life, 2013, West Dover, VT

• “Bacteria modificada genéticamente deficiente en la asimilación de alcoholes”. P201431826.
Gomez Garcia, Rosario, Cuenca Martin, Sol, Udaondo, Zulema, Roca Hernandez, Amalia, Ramos Martin, JL, Duque, Estrella. Abengoa Research. Country: Spain. Dec 2014

• “Celula microbiana modificada geneticamente con tolerancia mejorada frente a alcholes”. P2015330174
Gomez Garcia, Rosario, Cuenca Martin, Sol, Udaondo, Zulema, Roca Hernandez, Amalia, Ramos Martin, JL, Duque, Estrella. Abengoa Research Country: Spain. February 2015
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