Aya Ito-Ishida
  • Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo, Japan
Research focus
  • Developmental biology
  • 1 Author merit


M.D., School of Medicine, The University of Tokyo, 2003
Ph.D. in Physiology, School of Medicine, Keio University, 2009

Current position

Postdoctoral fellow, Department of Molecular and Human Genetics, Baylor College of Medicine. Her research focuses on molecular pathogenesis of neurodevelopmental disorders.


  1. Ito-Ishida, A., Miyazaki, T., Miura, E., Matsuda, K., Watanabe, M., Yuzaki, M. and Okabe, S. (2012). Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation. Neuron 76(3): 549-564.    
  2. Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., Fukazawa, Y., Ito-Ishida, A., Kondo, T., Shigemoto, R., Watanabe, M. and Yuzaki, M. (2010). Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science 328(5976): 363-368.    
  3. Ito-Ishida, A., Miura, E., Emi, K., Matsuda, K., Iijima, T., Kondo, T., Kohda, K., Watanabe, M. and Yuzaki, M. (2008). Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. J Neurosci 28(23): 5920-5930.  
  4. Ito-Ishida, A., Kakegawa, W. and Yuzaki, M. (2006). ERK1/2 but not p38 MAP kinase is essential for the long-term depression in mouse cerebellar slices. Eur J Neurosci 24(6): 1617-1622.    
  5. Ito, A., Honma, Y., Inamori, E., Yada, Y., Momoi, M. Y. and Nakamura, Y. (2006). Developmental outcome of very low birth weight twins conceived by assisted reproduction techniques. J Perinatol 26(2): 130-133.    
  6. Ito, A., Yamagata, T., Mori, M. and Momoi, M. Y. (2005). Early-onset ataxia with oculomotor apraxia with a novel APTX mutation. Pediatr Neurol 33(1): 53-56.    
  7. Ito, A., Uno, T., Gunji, Y., Yamauchi, T., Egami, S., Kawarasaki, H. and Momoi, M. Y. (2005). Obstructive jaundice as a presentation of ganglioneuroblastoma. J Pediatr Hematol Oncol 27(2): 112-114.    
  8. Yoshida, T., Ito, A., Matsuda, N. and Mishina, M. (2002). Regulation by protein kinase A switching of axonal pathfinding of zebrafish olfactory sensory neurons through the olfactory placode-olfactory bulb boundary. J Neurosci 22(12): 4964-4972.
1 Protocol published
Labeling of Precursor Granule Cells in the Cerebellum by ex vivo Electroporation
Author:  Aya Ito-Ishida, date: 06/20/2013, view: 14134, Q&A: 1
This protocol will be useful to introduce the genes of interest into the cerebellar granule cells at early stages of development. Since the granule cell precursors are localized in the external granule layer before migration, DNA plasmids can be ...
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