Fangfang Jiao Center for Infectious Disease Research, School of Medicine, Tsinghua University, China
1 protocol

Juanjuan Wang Center for Infectious Disease Research, School of Medicine, Tsinghua University, China
1 protocol

Jing Li Boston Children's Hospital and Harvard Medical School
1 protocol

Jing-Ren Zhang
  • Center for Infectious Disease Research, School of Medicine, Tsinghua University, China
Research focus
  • Microbiology
  • 1 Author merit


PHD, University of Texas Health Science Center, Houston, TX, USA, 1997

Current position

Professor, School of Medicine, Tsinghua University , China

Publications (since 2003)

  1. Li, J., Wang, J., Jiao, F. and Zhang, J. R. (2017). Observation of pneumococcal phase variation in colony morphology. Bio Protoc 7(15): e2434.
  2. Yu, Y., Li, J., Jiang, L., Zhang, J. R. and Zu, L. (2017). Catalytic Enantioselective Aza-pinacol Rearrangement. Angew Chem Int Ed Engl 56(31): 9217-9221.
  3. Liu, X., Gallay, C., Kjos, M., Domenech, A., Slager, J., van Kessel, S. P., Knoops, K., Sorg, R. A., Zhang, J. R. and Veening, J. W. (2017). High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae. Mol Syst Biol 13(5): 931.
  4. Liu, B., Liu, X., Zhang, J. R. and Liu, G. (2017). A Natural Lipotrisaccharide and Its Derivatives Selectively Lyse Streptococcus pneumoniae via Interaction with Cell Membrane. ACS Infect Dis 3(6): 438-453.
  5. Li, J., Li, J. W., Feng, Z., Wang, J., An, H., Liu, Y., Wang, Y., Wang, K., Zhang, X., Miao, Z., Liang, W., Sebra, R., Wang, G., Wang, W. C. and Zhang, J. R. (2016). Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae. PLoS Pathog 12(7): e1005762.
  6. Wen, Z., Liu, Y., Qu, F. and Zhang, J. R. (2016). Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae. Sci Rep 6: 30176.
  7. Li, G., Liang, Z., Wang, X., Yang, Y., Shao, Z., Li, M., Ma, Y., Qu, F., Morrison, D. A. and Zhang, J. R. (2016). Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence. Infect Immun 84(6): 1887-1901.
  8. He, L., Nair, M. K., Chen, Y., Liu, X., Zhang, M., Hazlett, K. R., Deng, H. and Zhang, J. R. (2016). The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host. Infect Immun 84(5): 1387-1402.
  9. Bai, X. H., Li, Q., Jiang, Y. L., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2016). Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB. Methods Mol Biol 1440: 271-283.
  10. Yang, H., Liu, X., Li, Q., Li, L., Zhang, J. R. and Tang, Y. (2016). Total synthesis and preliminary SAR study of (+/-)-merochlorins A and B. Org Biomol Chem 14(1): 198-205.
  11. Yang, T., Chen, G., Sang, Z., Liu, Y., Yang, X., Chang, Y., Long, H., Ang, W., Tang, J., Wang, Z., Li, G., Yang, S., Zhang, J., Wei, Y. and Luo, Y. (2015). Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies. J Med Chem 58(16): 6389-6409.
  12. Wang, L., Jiang, Y. L., Zhang, J. R., Zhou, C. Z. and Chen, Y. (2015). Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae. PLoS One 10(3): e0120467.
  13. Wen, Z., Sertil, O., Cheng, Y., Zhang, S., Liu, X., Wang, W. C. and Zhang, J. R. (2015). Sequence elements upstream of the core promoter are necessary for full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infect Immun 83(5): 1957-1972.
  14. Achila, D., Liu, A., Banerjee, R., Li, Y., Martinez-Hackert, E., Zhang, J. R. and Yan, H. (2015). Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae. Biochem J 465(2): 325-335.
  15. Feng, Z., Li, J., Zhang, J. R. and Zhang, X. (2014). qDNAmod: a statistical model-based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data. Nucleic Acids Res 42(22): 13488-13499.
  16. Zhu, D., Wang, L., Shang, G., Liu, X., Zhu, J., Lu, D., Wang, L., Kan, B., Zhang, J. R. and Xiang, Y. (2014). Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Mol Cell 55(6): 931-937.
  17. Zeng, X. F., Ma, Y., Yang, L., Zhou, L., Xin, Y., Chang, L., Zhang, J. R. and Hao, X. (2014). A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae. Res Microbiol 165(8): 630-638.
  18. Song, Y., Li, Q., Liu, X., Chen, Y., Zhang, Y., Sun, A., Zhang, W., Zhang, J. and Ju, J. (2014). Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria. J Nat Prod 77(8): 1937-1941.
  19. Bai, X. H., Chen, H. J., Jiang, Y. L., Wen, Z., Huang, Y., Cheng, W., Li, Q., Qi, L., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2014). Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. J Biol Chem 289(34): 23403-23416.
  20. Yang, Y. H., Jiang, Y. L., Zhang, J., Wang, L., Bai, X. H., Zhang, S. J., Ren, Y. M., Li, N., Zhang, Y. H., Zhang, Z., Gong, Q., Mei, Y., Xue, T., Zhang, J. R., Chen, Y. and Zhou, C. Z. (2014). Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLoS Pathog 10(6): e1004169.
  21. Pan, X., Yang, Y. and Zhang, J. R. (2014). Molecular basis of host specificity in human pathogenic bacteria. Emerg Microbes Infect 3(3): e23.
  22. Gupta, R., Yang, J., Dong, Y., Swiatlo, E., Zhang, J. R., Metzger, D. W. and Bai, G. (2013). Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infect Immun 81(10): 3903-3911.
  23. El Qaidi, S., Yang, J., Zhang, J. R., Metzger, D. W. and Bai, G. (2013). The vitamin B(6) biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection. J Bacteriol 195(10): 2187-2196.
  24. Li, G., Hu, F. Z., Yang, X., Cui, Y., Yang, J., Qu, F., Gao, G. F. and Zhang, J. R. (2012). Complete genome sequence of Streptococcus pneumoniae strain ST556, a multidrug-resistant isolate from an otitis media patient. J Bacteriol 194(12): 3294-3295.
  25. Han, H., Liu, C., Wang, Q., Xuan, C., Zheng, B., Tang, J., Yan, J., Zhang, J., Li, M., Cheng, H., Lu, G. and Gao, G. F. (2012). The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology 158(Pt 7): 1852-1866.
  26. Su, J., Asare, R., Yang, J., Nair, M. K., Mazurkiewicz, J. E., Abu-Kwaik, Y. and Zhang, J. R. (2011). The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS. Front Microbiol 2: 83.
  27. Zhang, Q., Gao, F., Peng, H., Cheng, H., Liu, Y., Tang, J., Thompson, J., Wei, G., Zhang, J., Du, Y., Yan, J. and Gao, G. F. (2009). Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism. J Bacteriol 191(18): 5832-5837.
  28. Chen, H., Ma, Y., Yang, J., O'Brien, C. J., Lee, S. L., Mazurkiewicz, J. E., Haataja, S., Yan, J. H., Gao, G. F. and Zhang, J. R. (2007). Genetic requirement for pneumococcal ear infection. PLoS One 3(8): e2950.
  29. Lu, L., Ma, Z., Jokiranta, T. S., Whitney, A. R., DeLeo, F. R. and Zhang, J. R. (2008). Species-specific interaction of Streptococcus pneumoniae with human complement factor H. J Immunol 181(10): 7138-7146.
  30. Ma, Z., and Zhang, J. R. (2007). RR06 activates the transcription of spr1996 and cbpA in Streptococcus pneumoniae. J Bacteriol 189: 2497-2509.
  31. Su, J., Yang, J., Zhao, D., Kawula, T. H., Banas, J. A. and Zhang, J. R. (2007). Genome-wide identification of Francisella tularensis virulence determinants. Infect Immun 75(6): 3089-3101.
  32. Lu, L., Ma, Y. and Zhang, J. R. (2006). Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. J Biol Chem 281(22): 15464-15474.
  33. Lu, L., Lamm, M. E., Li, H., Corthesy, B. and Zhang, J. R. (2003). The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J Biol Chem 278(48): 48178-48187.
1 Protocol published
Observation of Pneumococcal Phase Variation in Colony Morphology
Authors:  Jing Li, Juanjuan Wang, Fangfang Jiao and Jing-Ren Zhang, date: 08/05/2017, view: 8519, Q&A: 0
Streptococcus pneumoniae (pneumococcus) is an important human pathogen that causes pneumonia, meningitis, sepsis, and otitis media. This bacterium normally resides in the nasopharynx as a commensal, but sometimes disseminates to sterile ...
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