I am a Postdoctoral Fellow at CCHMC Fernanadez Lab at the Division of Pediatric Opthalmology, where my research focuses on deciphering how the brain’s master circadian pacemaker the suprachiasmatic nucleus (SCN) receives photic input from the retina and orchestrates internal timekeeping systems. My current work aims to unravel the mechanisms guiding the development of neural circuits that connect circadian and sensory systems during critical developmental windows.
With over 25 peer-reviewed publications during my PhD in internationally recognized journals, I bring extensive experience spanning in vitro systems, in vivo animal models, and translational biomaterials including peptides and nanoparticles. My broader scientific interests lie at the intersection of neurodevelopment, circadian biology, and regenerative neuroscience.
During my PhD, I pursued highly interdisciplinary research that bridged cutting-edge bioengineering and neurobiology. This included the development of brain-targeting nanotherapeutics aimed at improving outcomes in neurodegenerative diseases, stroke, and traumatic brain injuries. I worked on developing bioinspired nanomedicine platforms for the management of oxidative stress and promotion of neurogenesis in CNS injuries. Additionally, I developed a self-assembling multidomain peptides to enhance stem cell alignment, with implications for neural tissue engineering and repair. I also worked on extracellular matrix (ECM)-mimetic scaffolds for applications in neuropathic pain, neurogenesis, and brain repair.
https://www.cincinnatichildrens.org/research/divisions/o/ophthalmology/labs/fernandez/team
https://scholar.google.com/citations?hl=en&user=P65TKL0AAAAJ&view_op=list_works&sortby=pubdate1. Gharai P., Khan J., Mallesh R., Garg S., Gupta S., Jaisankar P., Ghosh. S. Discovery of Carbazole and Theophylline-Based Amyloid Inhibitor for the Promotion of Neuroprotection. ACS Chemical Neuroscience (Just Accepted) (Research Article)
2. Gupta, S., Jash, M., Khan, J., Garg, S., Roy, R., Arshi, M., Nayak, P., Ghosh, S. Discovery of potential Leonurine-based therapeutic lead MJ210 attenuates Parkinson's disease pathogenesis via NF-κB and MAPK pathways: Mechanistic insights from in vitro and in vivo rotenone models. European Journal of Medicinal Chemistry, 289, p.117471.
3. Khan, J., Gharai, P.K., Garg, S., Gupta, S., Arshi, M.U., Mallesh, R. and Ghosh, S. Discovery of Powerful Multifaceted Antioxidant for Combating Oxidative Stress Associated with Neurodegenerative Disorders. Acta Pharmaceutica Sinica B (Just Accepted) (Research Article)
4. Garg, S.,# Jana, A.,# Gupta, S., Arshi, M.U., Gharai, P., Khan, J., Roy, R., and Ghosh, S., 2024. “Discovery of Gallic Acid-Based Mitochondriotropic Antioxidant Attenuates LPS-Induced Neuroinflammation” Free Radical Biology Medicine 2024, 226, pp.302-329 (Research Article) # = Joint First Author
5. Jana, A.,# Garg, S.,# Ghosh,S., Khan, J., Roy, R., Mukherjee, N., Jash, M., Gupta, V., Prasunpriya, Nayak. and Ghosh, S. “Generation of Functional Neurons from Mesenchymal Stem Cells Using Neural Differentiator and Engineered Peptide Hydrogel: Potential Therapeutic Lead for Traumatic Brain Injury” ACS Applied Materials & Interfaces, 2024, 16, 47, 64476–64493 (Research Article) # = Joint First Author
6. Nandi, S., Ghosh, S., Garg, S. and Ghosh, S. Unveiling the Human Brain on a Chip: An Odyssey to Reconstitute Neuronal Ensembles and Explore Plausible Applications in Neuroscience. ACS Chemical Neuroscience, 2024, 15, 21, 3828–3847 (Review Article)
7. Samat, R., Sen, S., Ghosh, S., Jash, M., Garg, S., Sarkar, J. and Ghosh, S. Venom Peptide Therapeutics: A Promising Avenue for Antimicrobial Therapy ACS infectious diseases,2024, 10(9), pp.3098-3125 (Review Article)
8. Garg, S., Jana, A., Khan, J., Gupta, S., Roy, R., Gupta, V. and Ghosh, S., 2024 Logic "AND Gate Circuit" Based Mussel Inspired Polydopamine Nanocomposite as Bioactive Antioxidant for Management of Oxidative Stress and Neurogenesis in Traumatic Brain Injury. ACS Applied Materials & Interfaces, 2024, 16, 28, 36168–36193 (Research Article)
9. Gharai, P.K., Khan, J., Pradhan, K., Mallesh, R., Garg, S., Arshi, M.U., Barman, S. and Ghosh, S., 2024. Power of Dopamine: Multifunctional Compound Assisted Conversion of the Most Risk Factor into Therapeutics of Alzheimer’s Disease. ACS Chemical Neuroscience, 15(13), pp.2470-2483 (Research Article)
10. Mallesh, R., Khan, J., Gharai, P.K., Arshi, M.U., Garg, S., Gupta, S. and Ghosh, S., 2024. Hydrophobic C-Terminal Peptide Analog Aβ31–41 Protects the Neurons from Aβ-Induced Toxicity. ACS Chemical Neuroscience, 15(12), pp.2372-2385 (Research Article)
11. Gupta, V., Gharai, P.K., Kar, C., Garg, S. and Ghosh, S., 2024. Ratiometric Fluorescent Probe Promotes Trans-differentiation of Human Mesenchymal Stem Cells to Neurons. ACS Chemical Neuroscience, 15(2), pp.222-229 (Research Article)
12. Bhosle, A.A., Banerjee, M., Saha, S., Garg, S., Ghosh, S. and Chatterjee, A., 2023. An NIR-emissive AIEgen with dual sensing ability: An azine-based chemodosimeter for discriminative ppb-level detection of hydrazine and bisulfite ions. Sensors and Actuators B: Chemical, 397, p.134661 (Research Article)
13. Mallesh, R., Khan, J., Gharai, P.K., Ghosh, S., Garg, S., Arshi, M.U. and Ghosh, S., 2023. High-Affinity Fluorescent Probes for the Detection of Soluble and Insoluble Aβ Deposits in Alzheimer's Disease. ACS Chemical Neuroscience, 14(8), pp.1459-1473 (Research Article)
14. Gharai, P.K., Khan, J., Mallesh, R., Garg, S., Saha, A., Ghosh, S. and Ghosh, S., 2023. Vanillin benzothiazole derivative reduces cellular reactive oxygen species and detects amyloid fibrillar aggregates in Alzheimer's disease brain. ACS Chemical Neuroscience, 14(4), pp.773-786 (Research Article)
15. Gupta, V., Mahata, T., Roy, R., Gharai, P.K., Jana, A., Garg, S. and Ghosh, S., 2022. Discovery of imidazole-based GSK-3 β inhibitors for transdifferentiation of human mesenchymal stem cells to neurons: A potential single-molecule neurotherapeutic foresight. Frontiers in Molecular Neuroscience, 15, p.1002419 (Research Article)
16. Ghosh, S., Garg, S. and Ghosh, S., 2020. Cell-derived exosome therapy: a novel approach to treat post-traumatic brain injury mediated neural injury. ACS Chemical Neuroscience, 11(14), pp.2045-2047 (Viewpoint)
17. Mukherjee, N., Nandi, S., Garg, S., Ghosh, S., Ghosh, S., Samat, R. and Ghosh, S., 2020. Targeting chondroitin sulfate proteoglycans: an emerging therapeutic strategy to treat CNS injury. ACS Chemical Neuroscience, 11(3), pp.231-232 (Viewpoint)
18. Das, G., Ghosh, S., Garg, S., Ghosh, S., Jana, A., Samat, R., Mukherjee, N., Roy, R. and Ghosh, S., 2020. An overview of key potential therapeutic strategies for combat in the COVID-19 battle. RSC advances, 10(47), pp.28243-28266. (Review Article)
19. Mukherjee, N., Nandi, S., Ghosh, S., Garg, S. and Ghosh, S., 2019. Three-dimensional microfluidic platform with neural organoids: model system for unraveling synapses. ACS Chemical Neuroscience, 11(2), pp.101-102 (Viewpoint)
20. Garg, S., Bera, A., Roy, R., Ghosh, S. and Ghosh, S., 2024. Organ-on-a-chip for multianalyte monitoring. In Human Organs-on-a-Chip Technology (pp. 285-308). Academic Press. (Book Chapter)
21. Nandi, S., Ghosh, S., Garg, S., Sarkar, A. and Ghosh, S., 2022. Brain-on-a-chip. In Microfluidics and multi organs on chip (pp. 475-493). Singapore: Springer Nature Singapore. (Book Chapter)
22. Ghosh, S., Garg, S., Mukherjee, N. and Ghosh, S., 2022. Facile Method of Tubulin Purification from Goat Brain for Reconstitution of Microtubule-Associated Intracellular Function. In Microtubules: Methods and Protocols (pp. 17-45). New York, NY: Springer US. (Book Chapter)
23. Bioactive antioxidative neuroprotective nanoparticles for combating ros levels and neuron regeneration in traumatic brain injury. By Ghosh Surajit, Garg Shubham, Jana Aniket, Gupta Sanju, Umar Arshi Mohammad, Roy Rajsekhar. Indian Pat. Appl. (2023), IN 202311054293 (Patent)