Since 2000:
1. Dhyani, K. M., Dash, S., Joshi, S., Garg, A., Pal, D., Nishant, K. T. & Muniyappa, K. (2025) The ATPase activity of yeast chromosome axis protein Hop1 affects meiotic crossovers. Nucleic Acids Res. 53, gkae1264

2. Mudgal, S., Goyal, N., Manikandan, K., Saginela, R., Singhal, A., Nandi, S., Mahmud, A. K., Muniyappa, K. & Sinha, K. M. (2024) Cyclic di-AMP safeguards genomic stability by regulating RecA-dependent and -independent recombination pathways and enhances drug resistance in Mycobacterium smegmatis. PNAS Nexus 3 (12), pgae555.

3. Badugu, S., Dhyani, K. M. Thakur, M. & Muniyappa, K. (2024) Saccharomyces cerevisiae Rev7 regulates DSB repair pathway choice through binding and blocking Mre11 nuclease and Rad50 ATPase activities. eLife, 13: RP96933. DOI: https://doi.org/10.7554/eLife.96933.

4. Agarwal, A. & Muniyappa, K. (2024) Mycobacterium smegmatis putative Holliday junction resolvases RuvC and RuvX play complementary roles in the processing of branched DNA structures. J Biol Chem. 300, 107732. doi: 10.1016/j.jbc.2024.107732.

5. Bhattacharya, S., Agarwal, A. & Muniyappa, K. (2024) Deciphering the substrate specificity reveals that CRISPR-Cas12a is a bifunctional enzyme with both endo- and exonuclease activities. J. Mol. Biol. 436, 168550. PMID: 38575054

6. Samui, S., Biswas, S., Basak, S., Ghosh, S., Muniyappa, K. & Naskar, J. (2024) De novo designed aliphatic and aromatic peptides assemble into amyloid-like cytotoxic supramolecular nanofibrils. RSC Adv.14, 4382-4388.

7. Somashekara, S.C., Dhyani, K. M., Thakur, M. & Muniyappa, K. (2023) SUMOylation of Saccharomyces cerevisiae Pso2 enhances its translocation and accumulation in the mitochondria and attenuates methyl methanesulfonate-induced mitochondrial DNA damage. Mol. Microbiol. 120: 587–607.

8. Thakur, M. & Muniyappa, K. (2023) Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes. J. Biosci. 48: 56. DOI: 10.1007/s12038-023-00378-8

9. Roy, S., Maiti, B., Banerjee, N., Kaulage, M., Muniyappa, K., Chatterjee, S. & Bhattacharya, S. (2023) New xanthone derivatives as potent G-quadruplex binders for developing anti-cancer therapeutics. ACS Pharmacol. Trans. Sci. 6: 546-566.

10. Biswas, S., Basak, S., Samui, S., Pasadi, S., Muniyappa,K., & Naskar, J. (2023) Co-assembly of peptide with G-quadruplex DNA: A strategic approach to develop anticancer therapeutics. Chem. Select. 8: e20220356.

11. Roy, S., Chakroborty, N., Maiti, B., Muniyappa, K. & Bhattacharya, S. (2023) Design and synthesis of xanthone analogs conjugated with aza-aromatic substituents as promising G-quadruplex stabilizing ligands and their selective cancer cell cytotoxic action. ChemBioChem. 24: e202200609.

12. Thakur, M. & Muniyappa, K. (2023) Macrophage activation highlights a vital role for NER proteins in the survival, latency and multiplication of Mycobacterium tuberculosis. Tuberculosis 138: 102284.

13. Roy, S., Muniyappa, K. & Bhattacharya, S. (2022) Deciphering the Binding Insights of novel disubstituted anthraquinone derivatives with G-Quadruplex DNA exhibit selective cancer cell cytotoxicity. ChemMedChem. 17: e2022004.

14. Thakur, M., Parulekar, R. S., Barale, S. S., Sonawane, K. D. and Muniyappa, K. (2022) Interrogating the substrate specificity landscape of UvrC reveals novel insights into its noncanonical function. Biophysical Journal 121: 3103-3125.

15. Somashekara, S.C. & Muniyappa, K. (2022) Dual targeting of Saccharomyces cerevisiae Pso2 to mitochondria and the nucleus, and its functional relevance in the repair of DNA interstrand crosslinks. G3: Genes, Genomes & Genetics. 12: jkac066. doi: 10.1093/g3journal/jkac066.

16. Samui, S., Biswas, B., Muniyappa, K. & Naskar, J., (2021) Nano-assemblies of a synthetic peptide: Illuminating aggregation potential, amyloidogenicity and cytotoxicity. Chem. Select 6: 1-6. doi.org/10.1002/slct.202102570.

17. Thakur, M., Mohan, D., Singh, A. K., Agarwal. A., Gopal, B. & Muniyappa, K. (2021) Novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates through structure-guided studies of the Holliday junction resolvase RuvX. J. Mol. Biol. 433: 167014. doi: 10.1016/j.jmb.2021.167014.

18. Thakur, M., Agarwal, A. & Muniyappa, K. (2021) The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function. FEBS J. 288: 1179-1200.

19. Pasadi, S. & Muniyappa K (2020) Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11-Rad50-Nbs1 complex in the repair of cisplatin-induced DNA cross-links. Oncotarget 11: 4028-4044.

20. Biswas, S., Samui, S., Das, A. K., Pasadi, S., Muniyappa, K. & Naskar. J. (2020) Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells. RSC Adv.10: 26388–26396.

21. Prasad, D. & Muniyappa, K. (2020) The extended N-terminus of Mycobacterium smegmatis RecX potentiates its ability to antagonize RecA functions. Biochem. Biophys. Acta - Proteins and Proteomics. 1868: 140468. PMID: 32526474.

22. Majee, P., Shankar, U., Pasadi, S., Muniyappa, K., Nayak, D. & Kumar A. (2020) Genome-wide analysis reveals a regulatory role for G-quadruplexes during Adenovirus multiplication. Virus Res. 283:197960. doi: 10.1016/j.virusres.2020.

23. Roy, S., Ali, A., Kamra, M., Muniyappa, K. & Bhattacharya, S. (2020) Specific stabilization of promoter G-quadruplex DNA by 2,6-disubstituted amidoanthracene-9,10-dione based dimeric distamycin analogues and their selective cancer cell cytotoxicity. Eur. J. Med. Chem. 195: 112202, doi.org/10.1016/j.ejmech.2020.112202
24. Majee, P., Mishra, S.K., Pandya, N., Shankar, U., Pasadi, S., Muniyappa, K., Nayak, D. & Kumar, A. (2020) Identification and characterization of two conserved G-quadruplex forming motifs in the Nipah virus genome and their interaction with G-quadruplex specific ligands. Sci Rep. 10: 1477. doi: 10.1038/s41598-020-58406-8.
25. Thakur, M., Badugu, S., and Muniyappa, K. (2020) UvrA and UvrC subunits of the Mycobacterium tuberculosis UvrABC excinuclease interact independently of UvrB and DNA. FEBS Lett. 594: 851–863.
26. Thakur, M., and Muniyappa, K. (2020) Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB. Biochimie 170, 94-105.
27. Prasad, D. & Muniyappa, K. (2019) The anionic phospholipids in the plasma membrane play an important role in regulating the biochemical properties and biological functions of RecA proteins. Biochemistry 58: 1295-1310.
28. Prasad, D., Arora, D., Nandicoori, V. K. & Muniyappa, K. (2019) Elucidating the functional role of Mycobacterium smegmatis recX in stress response. Sci. Rep. 9(1):10912. doi: 10.1038/s41598-019-47312-3.
29. Dash, J. R., Mishra, S. K., Parida, S., Singh, T. U., Choudhury, S., & Muniyappa, K. (2019) TRPV4 activation in rat carotid artery in DOCA hypertension involves eNOS and endothelium-derived contractile factor (EDCF). Clin. Exp. Hypertens. 41: 564-570.

30. Manikandan, K.,® Prasad, D.,® Srivastava, A., Singh, N., Dabeer, S., Krishnan, A., Muniyappa, K© and Sinha, K. M.© (2018) The second messenger cyclic di-AMP negatively regulates the expression of Mycobacterium smegmatis recA and attenuates DNA strand exchange through binding to the C-terminal motif of mycobacterial RecA proteins. Mol. Microbiol. 109: 600-614. ®Equal first authors; ©Co-corresponding authors.

31. Kaulage, M. H., Maji, B., Pasadi, S., Ali, A., Bhattacharya, S., and Muniyappa, K. (2018) Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazolecarbazole ligands. Eur. J. Med. Chem. 148, 178-194.

32. Kaulage, M. H., Bhattacharya, S., and Muniyappa, K. (2018) Structural characterization of i-motif structure in the human acetyl-CoA carboxylase 1 gene promoters and their role in the regulation of gene expression. ChemBiochem. 19, 1078-1087.

33. Kaulage, M. H., Maji, B., Pasadi, S., Bhattacharya, S., and Muniyappa, K. (2017) Novel ruthenium azo-quinoline complexes with enhanced photonuclease activity in human cancer cells. Eur. J. Med. Chem. 139, 1016-1029.
34. Sharadamma, N., Harshavardhana, Y., and Muniyappa, K. (2017) Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination. J. Bacteriol. 199(19). pii: e00357-17.
35. Kshirsagar, R., Ghodke, I., and Muniyappa, K. (2017) Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA. J. Biol. Chem. 292, 13853-13866.
36. Kshirsagar, R., Khan, K., Joshi, M. V., Hosur, R. V., and Muniyappa, K. (2017) Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks. Biophys. J. 112, 2056-2074.
37. Ali, A., Kamra, M., Roy, S., Muniyappa, K., and Bhattacharya, S. (2017) Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes. Bioconjugate Chem. 28, 341-352.
38. Ghodke, I., and Muniyappa, K. (2016) Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress. J. Biosci. 41, 615-641.
39. Thakur, M., Kumar, M. B., and Muniyappa, K. (2016) Mycobacterium tuberculosis UvrB Is a Robust DNA-Stimulated ATPase That Also Possesses Structure-Specific ATP-Dependent DNA Helicase Activity. Biochemistry 55, 5865-5883.
40. Ali, A., Kamra, M., Roy, S., Muniyappa, K., and Bhattacharya, S. (2016) Novel Oligopyrrole Carboxamide based Nickel(II) and Palladium(II) Salens, Their Targeting of Human G-Quadruplex DNA, and Selective Cancer Cell Toxicity. Chemistry, an Asian Journal 11, 2542-2554.
41. Kaulage, M., Maji, B., Bhat, J., Iwasaki, Y., Chatterjee, S., Bhattacharya, S., and Muniyappa, K. (2016) Discovery and Structural Characterization of G-quadruplex DNA in Human Acetyl-CoA Carboxylase Gene Promoters: Its Role in Transcriptional Regulation and as a Therapeutic Target for Human Disease. J. Med.Chem. 59, 5035-5050.
42. Nautiyal, A., Rani, P. S., Sharples, G. J., and Muniyappa, K. (2016) Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain. Mol. Microbiol. 100, 656-674.
43. Manjunath, G. P., Soni, N., Vaddavalli, P. L., Shewale, D. J., Madhusudhan, M. S., and Muniyappa, K. (2016) Molecular Mechanism Underlying ATP-Induced Conformational Changes in the Nucleoprotein Filament of Mycobacterium smegmatis RecA. Biochemistry 55, 1850-1862.
44. Thakur, R. S., Basavaraju, S., Khanduja, J. S., Muniyappa, K., and Nagaraju, G. (2015) Mycobacterium tuberculosis RecG protein but not RuvAB or RecA protein is efficient at remodeling the stalled replication forks: implications for multiple mechanisms of replication restart in mycobacteria. J. Biol Chem. 290, 24119-24139.
45. Sharadamma, N., Harshavardhana, Y., Ravishankar, A., Anand, P., Chandra, N., and Muniyappa, K. (2015) Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction. Biochemistry 54, 4142-4160.
46. Maji, B., Kumar, K., Muniyappa, K., and Bhattacharya, S. (2015) New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer. Org. & Biomol. Chem. 13, 8335-8348.
47. Dewhare, S. S., Umesh, T. G., and Muniyappa, K. (2015) Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis. J. Biol. Chem. 290, 11948-11968.
48. Ujaoney, A. K., Basu, B., Muniyappa, K., and Apte, S. K. (2015) Functional roles of N-terminal and C-terminal domains in the overall activity of a novel single-stranded DNA binding protein of Deinococcus radiodurans. FEBS Open Bio 5, 378-387.
49. Chandran, A. V., Prabu, J. R., Nautiyal, A., Patil, K. N., Muniyappa, K., and Vijayan, M. (2015) Structural studies on Mycobacterium tuberculosis RecA: molecular plasticity and interspecies variability. J. Biosci. 40, 13-30.
50. Le, S., Chen, H., Zhang, X., Chen, J., Patil, K. N., Muniyappa, K., and Yan, J. (2014) Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis. Nucleic Acids Res. 42, 11992-11999
51. Maji, B., Kumar, K., Kaulage, M., Muniyappa, K., and Bhattacharya, S. (2014) Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells. J. Med.Chem. 57, 6973-6988.
52. Muniyappa, K., Kshirsagar, R., and Ghodke, I. (2014) The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions. Gene 545, 194-197.
53. Nautiyal, A., Patil, K. N., and Muniyappa, K. (2014) Suramin is a potent and selective inhibitor of M. tuberculosis RecA protein and the SOS response: RecA as a potential target for antibacterial drug discovery. J. Antimicro. Chemother. 69, 1834-1843.
54. Gupta, S., De, S., Srivastava, V., Hussain, M., Kumari, J., Muniyappa, K., and Sengupta, S. (2014) RECQL4 and p53 potentiate the activity of polymerase gamma and maintain the integrity of the human mitochondrial genome. Carcinogenesis 35, 34-45.
55. Khan, K., Madhavan, T. P., Kshirsagar, R., Boosi, K. N., Sadhale, P., and Muniyappa, K. (2013) N-terminal disordered domain of Saccharomyces cerevisiae Hop1 protein is dispensable for DNA binding, bridging, and synapsis of double-stranded DNA molecules but is necessary for spore formation. Biochemistry 52, 5265-5279.
56. Raj, S. M., Halebeedu, P., Kadandale, J. S., Mirazon Lahr, M., Gallego Romero, I., Yadhav, J. R., Iliescu, M., Rai, N., Crivellaro, F., Chaubey, G., Villems, R., Thangaraj, K., Muniyappa, K., Chandra, H. S., and Kivisild, T. (2013) Variation at diabetes- and obesity-associated Loci may mirror neutral patterns of human population diversity and diabetes prevalence in India. Ann.Human Genet. 77, 392-408.
57. Ghodke, I., and Muniyappa, K. (2013) Processing of DNA double-stranded breaks and intermediates of recombination and repair by Saccharomyces cerevisiae Mre11 and its stimulation by Rad50, Xrs2, and Sae2 proteins. J. Biol. Chem. 288, 11273-11286.
58. Thakur, R. S., Basavaraju, S., Somyajit, K., Jain, A., Subramanya, S., Muniyappa, K., and Nagaraju, G. (2013) Evidence for the role of Mycobacterium tuberculosis RecG helicase in DNA repair and recombination. FEBS J. 280, 1841-1860
59. Fu, H., Le, S., Muniyappa, K., and Yan, J. (2013) Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA. PLoS one 8, e66712
60. Fu, H., Le, S., Chen, H., Muniyappa, K., and Yan, J. (2013) Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein. Nucleic Acids Res. 41, 924-932
61. Khan, K., Karthikeyan, U., Li, Y., Yan, J., and Muniyappa, K. (2012) Single-molecule DNA analysis reveals that yeast Hop1 protein promotes DNA folding and synapsis: implications for condensation of meiotic chromosomes. ACS Nano 6, 10658-10666.
62. Khanduja, J. S., and Muniyappa, K. (2012) Functional analysis of DNA replication fork reversal catalyzed by M. tuberculosis RuvAB proteins. J. Biol. Chem. 287, 1345-1360.
63. Paul, A., Maji, B., Misra, S. K., Jain, A. K., Muniyappa, K., and Bhattacharya, S. (2012) Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Troger's base based novel benzimidazole derivatives. J. Med. Chem. 55, 7460-7471.
64. Jain, A. K., Paul, A., Maji, B., Muniyappa, K., and Bhattacharya, S. (2012) Dimeric 1,3-phenylene-bis(piperazinyl benzimidazole)s: synthesis and structure-activity investigations on their binding with human telomeric G-quadruplex DNA and telomerase inhibition properties. J. Med. Chem 55, 2981-2993.
65. Paul, A., Jain, A. K., Misra, S. K., Maji, B., Muniyappa, K., and Bhattacharya, S. (2012) Binding of gemini bisbenzimidazole drugs with human telomeric G-quadruplex dimers: effect of the spacer in the design of potent telomerase inhibitors. PLoS One 7, e39467.
66. Patil, K. N., Singh, P., Harsha, S., and Muniyappa, K. (2011) Mycobacterium leprae RecA is structurally analogous but functionally distinct from Mycobacterium tuberculosis RecA protein. Biochim. Biophys. Acta 1814, 1802-1811.
67. Rossi, F., Khanduja, J. S., Bortoluzzi, A., Houghton, J., Sander, P., Guthlein, C., Davis, E. O., Springer, B., Bottger, E. C., Relini, A., Penco, A., Muniyappa, K., and Rizzi, M. (2011) The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action. Nucleic Acids Res. 39, 7316-7328.
68. Sharadamma, N., Khan, K., Kumar, S., Patil, K. N., Hasnain, S. E., and Muniyappa, K. (2011) Synergy between the N-terminal and C-terminal domains of Mycobacterium tuberculosis HupB is essential for high-affinity binding, DNA supercoiling and inhibition of RecA-promoted strand exchange. FEBS J. 278, 3447-3462.
69. Patil, K. N., Singh, P., and Muniyappa, K. (2011) DNA binding, coprotease, and strand exchange activities of mycobacterial RecA proteins: implications for functional diversity among RecA nucleoprotein filaments. Biochemistry 50, 300-311.
70. Kaushal, P. S., Singh, P., Sharma, A., Muniyappa, K., and Vijayan, M. (2010) X-ray and molecular-dynamics studies on Mycobacterium leprae single-stranded DNA-binding protein and comparison with other eubacterial SSB structures. Acta Crystallogr. D Biol. Crystallogr. 66, 1048-1058.
71. Kumar, S., Sardesai, A. A., Basu, D., Muniyappa, K., and Hasnain, S. E. (2010) DNA clasping by mycobacterial HU: the C-terminal region of HupB mediates increased specificity of DNA binding. PLoS One 5, pii: e12551.
72. Chandran, A. V., Prabu, J. R., Manjunath, G. P., Patil, K. N., Muniyappa, K., and Vijayan, M. (2010) Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66, 1093-1095.
73. Kavitha, C. V., Choudhary, B., Raghavan, S. C., and Muniyappa, K. (2010) Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells. Biochem. Biophys. Res. Commun. 399, 575-580.
74. Singh, P., Patil, K. N., Khanduja, J. S., Kumar, P. S., Williams, A., Rossi, F., Rizzi, M., Davis, E. O., and Muniyappa, K. (2010) Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins. Biochemistry 49, 4872-4883.
75. Khan, K., Madhavan, T. P., and Muniyappa, K. (2010) Cloning, overexpression and purification of functionally active Saccharomyces cerevisiae Hop1 protein from Escherichia coli. Protein Expr. Purif. 72, 42-47.
76. Sharadamma, N., Harshavardhana, Y., Singh, P., and Muniyappa, K. (2010) Mycobacterium tuberculosis nucleoid-associated DNA-binding protein H-NS binds with high-affinity to the Holliday junction and inhibits strand exchange promoted by RecA protein. Nucleic Acids Res. 38, 3555-3569.
77. Muniyappa, K. (2010) Telomere length maintenance as a target for anticancer drug discovery. Med. Chem. Res. 19, 28-29.
78. Singh, P., Tripathi, P., and Muniyappa, K. (2010) Mutational analysis of active-site residues in the Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease: Asp(122) and Asp(193) are crucial to the double-stranded DNA cleavage activity whereas Asp(218) is not. Protein Science 19, 111-123.
79. Jain, A. K., Reddy, V. V., Paul, A., K, M., and Bhattacharya, S. (2009) Synthesis and evaluation of a novel class of G-quadruplex-stabilizing small molecules based on the 1,3-phenylene-bis(piperazinyl benzimidazole) system. Biochemistry 48, 10693-10704.
80. Singh, P., Tripathi, P., Silva, G. H., Pingoud, A., and Muniyappa, K. (2009) Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease. J. Biol. Chem. 284, 25912-25928.
81. Prabu, J. R., Thamotharan, S., Khanduja, J. S., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2009) Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 1794, 1001-1009.
82. Khanduja, J. S., Tripathi, P., and Muniyappa, K. (2009) Mycobacterium tuberculosis RuvA induces two distinct types of structural distortions between the homologous and heterologous Holliday junctions. Biochemistry 48, 27-40.
83. Kavitha, C. V., Nambiar, M., Ananda Kumar, C. S., Choudhary, B., Muniyappa, K., Rangappa, K. S., and Raghavan, S. C. (2009) Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells. Biochem. Pharmacol. 77, 348-363
84. Prabu, J. R., Manjunath, G. P., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2008) Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes. Acta Crystallogr. D Biol. Crystallogr. 64, 1146-1157.
85. Tripathi, P., Pal, D., and Muniyappa, K. (2007) Saccharomyces cerevisiae Hop1 protein zinc finger motif binds to the Holliday junction and distorts the DNA structure: implications for holliday junction migration. Biochemistry 46, 12530-12542.
86. Ghosal, G., and Muniyappa, K. (2007) The characterization of Saccharomyces cerevisiae Mre11/Rad50/Xrs2 complex reveals that Rad50 negatively regulates Mre11 endonucleolytic but not the exonucleolytic activity. J. Mol.Biol. 372, 864-882.
87. Krishna, R., Prabu, J. R., Manjunath, G. P., Datta, S., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2007) Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA. J. Mol.Biol. 367, 1130-1144.
88. Tripathi, P., Anuradha, S., Ghosal, G., and Muniyappa, K. (2006) Selective binding of meiosis-specific yeast Hop1 protein to the Holliday junctions distorts the DNA structure and its implications for junction migration and resolution. J. Mol.Biol. 364, 599-611.
89. Krishna, R., Manjunath, G. P., Kumar, P., Surolia, A., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2006) Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery. Nucleic Acids Res. 34, 2186-2195.
90. Prabu, J. R., Thamotharan, S., Khanduja, J. S., Alipio, E. Z., Kim, C. Y., Waldo, G. S., Terwilliger, T. C., Segelke, B., Lekin, T., Toppani, D., Hung, L. W., Yu, M., Bursey, E., Muniyappa, K., Chandra, N. R., and Vijayan, M. (2006) Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62, 731-734.
91. Ghosal, G., and Muniyappa, K. (2006) Hoogsteen base-pairing revisited: resolving a role in normal biological processes and human diseases. Biochem. Biophys. Res. Commun. 343, 1-7.
92. Anuradha, S., Tripathi, P., Mahajan, K., and Muniyappa, K. (2005) Meiosis-specific yeast Hop1 protein promotes pairing of double-stranded DNA helices via G/C isochores. Biochem. Biophys. Res. Commun. 336, 934-941.
93. Saikrishnan, K., Manjunath, G. P., Singh, P., Jeyakanthan, J., Dauter, Z., Sekar, K., Muniyappa, K., and Vijayan, M. (2005) Structure of Mycobacterium smegmatis single-stranded DNA-binding protein and a comparative study involving homologus SSBs: biological implications of structural plasticity and variability in quaternary association. Acta Crystallogr. D Biol. Crystallogr. 61, 1140-1148.
94. Ghosal, G., and Muniyappa, K. (2005) Saccharomyces cerevisiae Mre11 is a high-affinity G4 DNA-binding protein and a G-rich DNA-specific endonuclease: implications for replication of telomeric DNA. Nucleic Acids Res. 33, 4692-4703.
95. Anuradha, S., and Muniyappa, K. (2004) Saccharomyces cerevisiae Hop1 zinc finger motif is the minimal region required for its function in vitro. J. Biol. Chem. 279, 28961-28969.
96. Anuradha, S., and Muniyappa, K. (2004) Meiosis-specific yeast Hop1 protein promotes synapsis of double-stranded DNA helices via the formation of guanine quartets. Nucleic Acids Res. 32, 2378-2385.
97. Ganesh, N., and Muniyappa, K. (2003) Mycobacterium smegmatis RecA protein is structurally similar to but functionally distinct from Mycobacterium tuberculosis RecA. Proteins 53, 6-17.
98. Guhan, N., and Muniyappa, K. (2003) Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn2+ and DNA-dependent ATPase activity. Nucleic Acids Res. 31, 4184-4191.
99. Ganesh, N., and Muniyappa, K. (2003) Characterization of DNA strand transfer promoted by Mycobacterium smegmatis RecA reveals functional diversity with Mycobacterium tuberculosis RecA. Biochemistry 42, 7216-7225.
100. Datta, S., Krishna, R., Ganesh, N., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2003) Crystal structures of Mycobacterium smegmatis RecA and its nucleotide complexes. J. Bacteriol. 185, 4280-4284.
101. Datta, S., Ganesh, N., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2003) Structural studies on MtRecA-nucleotide complexes: insights into DNA and nucleotide binding and the structural signature of NTP recognition. Proteins 50, 474-485.
102. Venkatesh, R., Ganesh, N., Guhan, N., Reddy, M. S., Chandrasekhar, T., and Muniyappa, K. (2002) RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: insights into negative regulation of homologous recombination. Proc. Natl. Acad. Sci. U. S. A. 99, 12091-12096.
103. Guhan, N., and Muniyappa, K. (2002) The RecA intein of Mycobacterium tuberculosis promotes cleavage of ectopic DNA sites. Implications for the dispersal of inteins in natural populations. J. Biol. Chem. 277, 40352-40361.
104. Guhan, N., and Muniyappa, K. (2002) Mycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activity. J. Biol. Chem. 277, 16257-16264.
105. Reddy, M. S., Guhan, N., and Muniyappa, K. (2001) Characterization of single-stranded DNA-binding proteins from Mycobacteria. The carboxyl-terminal of domain of SSB is essential for stable association with its cognate RecA protein. J. Biol. Chem. 276, 45959-45968.
106. Bakshi, R. P., Galande, S., Bali, P., Dighe, R., and Muniyappa, K. (2001) Developmental and hormonal regulation of type II DNA topoisomerase in rat testis. J. Mol.Endocrinol. 26, 193-206.
107. Bakshi, R., Galande, S., and Muniyappa, K. (2001) Substrate specificity plays an important role in uncoupling the catalytic and scaffolding activities of rat testis DNA topoisomerase IIalpha. J. Biomol. Struct. Dyn. 18, 749-760
108. Datta, S., Prabu, M. M., Vaze, M. B., Ganesh, N., Chandra, N. R., Muniyappa, K., and Vijayan, M. (2000) Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Res. 28, 4964-4973.
109. Reddy, M. S., Vaze, M. B., Madhusudan, K., and Muniyappa, K. (2000) Binding of SSB and RecA protein to DNA-containing stem loop structures: SSB ensures the polarity of RecA polymerization on single-stranded DNA. Biochemistry 39, 14250-14262.
110. Muniyappa, K., Vaze, M. B., Ganesh, N., Sreedhar Reddy, M., Guhan, N., and Venkatesh, R. (2000) Comparative genomics of Mycobacterium tuberculosis and Escherichia coli for recombination (rec) genes. Microbiology 146, 2093-2095.
111. Muniyappa, K., Anuradha, S., and Byers, B. (2000) Yeast meiosis-specific protein Hop1 binds to G4 DNA and promotes its formation. Mol. Cell. Biol. 20, 1361-1369