Education
Doctor, University of Lisbon, 2017
Lab information
Ribeiro's Lab specializes in analytical development for cell therapies, with a particular focus on CAR-T and TILs. The lab is dedicated to designing, optimizing, and implementing advanced analytical methods for the characterization of the starting material, in-process samples, and final products of these cell therapies, which are currently in clinical phases. The team utilizes state-of-the-art techniques for the characterization of cell phenotypes, function, and potency to ensure the quality, safety, and efficacy of these cell-based therapies. This includes flow cytometry for immune cell profiling, functional assays to assess cytotoxicity, and potency assays to evaluate therapeutic effectiveness. Additionally, Ribeiro's Lab focuses on troubleshooting analytical challenges and supporting process development. Through rigorous testing and innovation, Ribeiro's Lab plays a key role in advancing the field of cell therapies, particularly in CAR-T and TIL therapies.
https://www.tigenpharma.com
Research focus
Proteasome, Cell Signaling, T-Cell Differentiation, Tumor Immunology, T-Cell Activation, Tumor Targeting, Cell Therapy, Cell Counting, Cell Viability Testing, T Cell Characterization, Phenotypic Analysis, T Cell Function, Cytokine Quantification, Cell Culture, Co-culture Assays, Immunotherapy, Non-GMP Environment, GMP Environment, Cell-Based Assays, Flow Cytometry, Cytotoxicity Assays, Cellular Immunology, Therapeutic Cell Delivery, Cellular Immunotherapy.
Publications
https://orcid.org/0000-0002-6883-7590Chavarria, C., Zaffalon, L., Ribeiro, S. T., Op, M., Quadroni, M., Iatrou, M. S., Chapuis, C., Martinon, F. (2023). ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation. iScience, 2023-08. DOI: 10.1016/j.isci.2023.107777.
Ribeiro, S. T., de Gassart, A., Bettigole, S., Zaffalon, L., Chavarria, C., Op, M., Nugraha, K., Martinon, F. (2022). The protease DDI2 regulates NRF1 activation in response to cadmium toxicity. iScience, 2022-10. DOI: 10.1016/j.isci.2022.105227.
Op, M., Ribeiro, S. T., Chavarria, C., de Gassart, A., Zaffalon, L., Martinon, F. (2022). The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma. Cell Death & Disease, 2022-05. DOI: 10.1038/s41419-022-04925-3.
Ribeiro, S. T., Barata, J. T., Silva-Santos, B. (2017). Multifaceted CK2 in malignant and healthy T cells. Oncotarget, 2017. DOI: 10.18632/oncotarget.21700.
Ribeiro, S. T. (2016). Casein Kinase 2 controls the survival of normal thymic and leukemic γδ T-cells via promotion of AKT signaling. Leukemia, 2016-11-30. DOI: 10.1038/leu.2016.363.
Ribeiro, S. T., Ribot, J. C., Silva-Santos, B. (2015). Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation. Frontiers in Immunology, 2015. DOI: 10.3389/fimmu.2015.00015.
Ribot, J. C., Ribeiro, S. T., Correia, D. V., Sousa, A. E., Silva-Santos, B. (2014). Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling. The Journal of Immunology, 2014-03. DOI: 10.4049/jimmunol.1303119.