WM
Wenxin Ma
  • Research Associate, NIH
Research fields
  • Cell Biology, Immunology, Molecular Biology, Neuroscience, Stem Cell
Personal information

Education

Doctor

Research focus

Microglia and retinal neuroinflammation
Microglia differentiation form hiPSC
Microglia as a therapeutic target through cell replacement

Publications

Miyagishima KJ, Nadal-Nicolás FM, Ma W, Li W. Annexin-V binds subpopulation of immune
cells altering its interpretation as an in vivo biomarker for apoptosis in the retina. Int J Biol Sci.
2024 Nov 11;20(15):6073-6089. doi: 10.7150/ijbs.102551. PMID: 39664578; PMCID:
PMC11628321.

Ma W, Zhao L, Xu B, Fariss RN, Redmond TM, Zou J, Wong WT, Li W. Human-
induced pluripotent stem cell-derived microglia integrate into mouse retina and
recapitulate features of endogenous microglia. Elife. 2024 Nov 8;12:RP90695. doi:
10.7554/eLife.90695. PMID: 39514271.

Silverman SM, Ma W, Wang X, Zhao L and Wong WT. C3- and CR3-dependent microglial
clearance protects photoreceptors in retinitis pigmentosa. J Exp Med, 2019,5;216(8):1925-1943.

Ma W, Silverman SM, Zhao L, Villasmil R, Campos MM, Amaral J, Wong WT. Absence of
TGFb signaling in retinal microglia induces retinal degeneration and exacerbates choroidal
Neovascularization. eLife, 2019;8:e42049.


Ma W, Zhang Y, Gao Ch, Fariss RN, Tam J and Wong WT. Monocyte infiltration and
proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal
pigment epithelial cell injury. Sci Rep. 2017, 16;7(1):8433.

Ma W and Wong WT. Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. Adv Exp Med Biol. 2016; 854:73-8

Zhao L, Zabel M, Wang X, Ma W, Shah P, Fariss RN, Qian H-H, Parkhurst C, Gan W, and Wong WT. Microglial phagocytosis of living rod photoreceptors contributes to inherited retinal degeneration. EMBO Mol Med. 2015, 7(9): 1179-97.

Ma W, Indaram M, Zhao L, Fariss R, Rodriguez I, and Wong WT. 7-Ketocholesterol Increases Retinal Microglial Migration, Activation, and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration. Scientific Reports, 2015, 16;7(1):8433.

Ma W, Cojocaru R, Gotoh N, Gieser L, Villasmil R, Cogliati T, Swaroop A and Wong WT. Gene Expression Changes in Aging Retinal Microglia: Relationship to Microglial Support Functions and Regulation of Microglial Activation, Neurobiology of Aging, 2013, 34(10):2310-21.

Ma W, Coon LS, Zhao L, Fariss RN & Wong WT. A2E accumulation influences retinal microglia activation and complement regulation. Neurobiology of Aging, 2013(34):943-960.

Ma W & Wang S-Z. Fate tracing of neurogenin2-expressing cells in the mouse retina using CreERTM - LacZ. Retinal Development: Methods Mol Biol. 2012(884): 141-152.

Ma W, Zhao L & Wong WT. Microglia in the Outer Retina and Their Relevance to Pathogenesis of Age-Related Macular Degeneration. Retinal Degenerative Diseases, Advances in Experimental Medicine and Biology, Chapter 6. 2012; 723:37-42

Wang M, Ma W, Zhao L, Fariss RN & Wong WT. Adaptive Muller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina. J Neuroinflammation. 2011, 8:173

Zhao L, Ma W, Fariss RN and Wong WT. Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial inhibition as a potential therapeutic strategy. Am J pathol. 2011, 179(3), 1265-77.

Wang S-Z, Ma W, Yan R-T Mao W. Generating Retinal Neurons by Rreprogramming RPE cells. Expert Opin Biol Ther. 2010 Aug; 10(8):1227-39. (Review)

Ma W, Zhao L, Fontainhas AM, Fariss RN and Wong WT. Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD. PlosOne, 2009, Volume4, Issue 11, e7945.

Ma W, Yan R-T, Li X and Wang S-Z, Reprogramming RPE to differentiate towards retinal neurons with Sox2, Stem Cells. 2009 Jun; 27(6):1376-87.

Ma W, Yan R-T, Mao W and Wang S-Z. Ngn3 promotes early retinal neurogenesis, Mol Cell Neurosci. 2009 Feb; 40(2):187-98.

Ma W, Wang S-Z. The final fates of neurogenin2-expressing cells include all major neuron types in the mouse retina. Mol Cell Neurosci. 2006 Mar; 31(3):463-9.

Ma W, Yan R-T, Xie W, and Wang S-Z. A Role of ath5 in Inducing neuroD and the Photoreceptor Pathway. J. Neurosci. 2004 24: 7150-7158.

Ma W, Yan R-T and Wang S-Z. bHLH genes cath5 and cNSCL1 promote bFGF-stimulated RPE cells to transdifferentiate toward retinal ganglion cells. Dev Biol. 2004 Jan 15;265(2):320-8.
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