Reviewer
Kundlik Gadhave
  • Post-Doc, Johns Hopkins University
Research fields
  • Biochemistry, Biophysics, Cell Biology, Molecular Biology, Neuroscience
Personal information

Education

Ph.D., IIT Mandi, 2020

Research focus

Neuroscience and Neurovirology

Publications

https://scholar.google.com/citations?view_op=list_works&hl=en&hl=en&user=TUuYTTsAAAAJ&sortby=pubdate
1. Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Kotha S, Kuo G, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, Workman CJ, Vignali DAA, Pletinkova O, Jia H, Peng W, Nauen DW, Wong PC, Redding-Ochoa J, Troncoso JC, Ying M, Dawson VL, Dawson TM, Mao X. Lymphocyte- Activation Gene 3 Facilitates Pathological Tau Neuron-to-Neuron Transmission. Adv Sci. 2024 Apr;11(16):e2303775. doi: 10.1002/advs.202303775. Epub 2024 Feb 7. PMID: 38327094; PMCID: PMC11040377.
2. Choi CY#, Gadhave K#, Villano J, Pekosz A, Mao X, Jia H. Generation and characterization of a humanized ACE2 mouse model to study long-term impacts of SARS-CoV-2 infection. J Med Virol. 2024 Jan;96(1):e29349. doi: 10.1002/jmv.29349. PMID: 38185937; PMCID: PMC10783855. (# contributed equally).
3. Giri R, Bhardwaj T, Kapuganti SK, Saumya KU, Sharma N, Bhardwaj A, Joshi R, Verma D, Gadhave K. Widespread amyloid aggregates formation by Zika virus proteins and peptides. Protein Sci. 2023 Dec;32(12):e4833. doi: 10.1002/pro.4833. PMID: 37937856; PMCID: PMC10682691.
4. Sharma S, Goel V, Kaur P, Gadhave K, Garg N, Das Singla L, Choudhury D. Targeted drug delivery using beeswax-derived albendazole-loaded solid lipid nanoparticles in Haemonchus contortus, an albendazole-tolerant nematode. Exp Parasitol. 2023 Oct;253:108593. doi: 10.1016/j.exppara.2023.108593. Epub 2023 Aug 16. PMID: 37595879.
5. Bhardwaj T, Gadhave K, Kapuganti SK, Kumar P, Brotzakis ZF, Saumya KU, Nayak N, Kumar A, Joshi R, Mukherjee B, Bhardwaj A, Thakur KG, Garg N, Vendruscolo M, Giri R. Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes. Nat Commun. 2023 Feb 20;14(1):945. doi: 10.1038/s41467-023-36234-4. PMID: 36806058; PMCID: PMC9940680.
6. Gadhave K, Kapuganti SK, Mishra PM, Giri R. p53 TAD2 Domain (38-61) Forms Amyloid-like Aggregates in Isolation. ACS Chem Neurosci. 2022 Aug 3;13(15):2281-2287. doi: 10.1021/acschemneuro.1c00860. Epub 2022 Jul 20. PMID: 35856925.
7. Butler YR, Liu Y, Kumbhar R, Zhao P, Gadhave K, Wang N, Li Y, Mao X, Wang W. α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice. Nat Commun. 2022 Jul 19;13(1):4060. doi: 10.1038/s41467-022-31787-2. PMID: 35853942; PMCID: PMC9296447.
8. Gehi BR, Gadhave K, Uversky VN, Giri R. Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling. Cell Mol Life Sci. 2022 Mar 24;79(4):202. doi: 10.1007/s00018-022-04230-4. PMID: 35325330; PMCID: PMC11073203.
9. Kaur P, Ghosh S, Bhowmick A, Gadhave K, Datta S, Ghosh A, Garg N, Mahajan RL, Basu B, Choudhury D. Bacterioboat-A novel tool to increase the half-life period of the orally administered drug. Sci Adv. 2022 Mar 11;8(10):eabh1419. doi: 10.1126/sciadv.abh1419. Epub 2022 Mar 11. PMID: 35275724; PMCID: PMC8916724.
10. Sharma N#, Gadhave K#, Kumar P#, Giri R. Transactivation domain of Adenovirus Early Region 1A (E1A): Investigating folding dynamics and aggregation. Curr Res Struct Biol. 2022 Jan 13;4:29-40. doi: 10.1016/j.crstbi.2022.01.001. PMID: 35146445; PMCID: PMC8801969. (# contributed equally).
11. Gadhave K, Bhardwaj T, Uversky VN, Vendruscolo M, Giri R. The signal peptide of the amyloid precursor protein forms amyloid-like aggregates and enhances Ab42 aggregation. Cell Rep Phys Sci. 2, 100599 Oct 20, 2021. doi: 10.1016/j.xcrp.2021.100599.
12. Ayatollahi SA, Sharifi-Rad J, Tsouh Fokou PV, Mahady GB, Ansar Rasul Suleria H, Krishna Kapuganti S, Gadhave K, Giri R, Garg N, Sharma R, Ribeiro D, Rodrigues CF, Reiner Ž, Taheri Y, Cruz-Martins N. Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection. Front Pharmacol. 2021 Jun 29;12:575877. doi: 10.3389/fphar.2021.575877. PMID: 34267652; PMCID: PMC8277242.
13. Kaur P, Gadhave K, Garg N, Deb D, Choudhury D. Probing the interaction of glutathione with different shape of silver-nanoparticles by optical spectroscopy. Mat Tod Commun. Vol 26, Mar 2021, 102137. doi: 10.1016/j.mtcomm.2021.102137.
14. Khan AN, Gadhave K, Furkan M, Kumar P, Siddiqi MK, Giri R, Khan RH. Anti-tuberculotic thionamide antibiotics show antioxidative and neuronal cytoprotective nature by inhibiting amyloid formation in human insulin and amyloid β-42. Jour of Mol Liq. Vol 326, 15 Mar 2021, 115396. doi: 10.1016/j.molliq.2021.115396.
15. Sharma NR, Gadhave K, Kumar P, Saif M, Khan MM, Sarkar DP, Uversky VN, Giri R. Analysis of the dark proteome of Chandipura virus reveals maximum propensity for intrinsic disorder in phosphoprotein. Sci Rep. 2021 Jun 24;11(1):13253. doi: 10.1038/s41598-021-92581-6. PMID: 34168211; PMCID: PMC8225862.
16. Gadhave K, Kumar P, Kumar A, Bhardwaj T, Garg N, Giri R. Conformational dynamics of 13 amino acids long NSP11 of SARS-CoV-2 under membrane mimetics and different solvent conditions. Microb Pathog. 2021 Sep;158:105041. doi: 10.1016/j.micpath.2021.105041. Epub 2021 Jun 10. PMID: 34119626; PMCID: PMC8191288.
17. Saumya KU, Gadhave K, Kumar A, Giri R. Zika virus capsid anchor forms cytotoxic amyloid-like fibrils. Virology. 2021 Aug;560:8-16. doi: 10.1016/j.virol.2021.04.010. Epub 2021 May 15. PMID: 34020329.
18. Gadhave K, Kumar D, Uversky VN, Giri R. A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy. Med Res Rev. 2021 Sep;41(5):2689-2745. doi: 10.1002/med.21719. Epub 2020 Aug 11. PMID: 32783388; PMCID: PMC7876169.
19. Giri R, Bhardwaj T, Shegane M, Gehi BR, Kumar P, Gadhave K, Oldfield CJ, Uversky VN. Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses. Cell Mol Life Sci. 2021 Feb;78(4):1655-1688. doi: 10.1007/s00018-020-03603-x. Epub 2020 Jul 25. PMID: 32712910; PMCID: PMC7382329.
20. Kumar D, Mishra PM, Gadhave K, Giri R. Conformational dynamics of p53 N-terminal TAD2 region under different solvent conditions. Arch Biochem Biophys. 2020 Aug 15;689:108459. doi: 10.1016/j.abb.2020.108459. Epub 2020 Jun 24. PMID: 32592801.
21. Bhardwaj T, Saumya KU, Kumar P, Sharma N, Gadhave K, Uversky VN, Giri R. Japanese encephalitis virus - exploring the dark proteome and disorder-function paradigm. FEBS J. 2020 Sep;287(17):3751-3776. doi: 10.1111/febs.15427. Epub 2020 Jun 18. PMID: 32473054.
22. Gadhave K, Kumar P, Kapuganti SK, Uversky VN, Giri R. Unstructured Biology of Proteins from Ubiquitin-Proteasome System: Roles in Cancer and Neurodegenerative Diseases. Biomolecules. 2020 May 21;10(5):796. doi: 10.3390/biom10050796. PMID: 32455657; PMCID: PMC7278180.
23. Gadhave K, Giri R. Amyloid formation by intrinsically disordered trans- activation domain of cMyb. Biochem Biophys Res Commun. 2020 Apr 2;524(2):446-452. doi: 10.1016/j.bbrc.2020.01.110. Epub 2020 Jan 30. PMID: 32007275.
24. Kaur P, Sharma S, Choudhury SD, Singh D, Sharma S, Gadhave K, Garg N, Choudhury D. Insulin-copper quantum clusters preparation and receptor targeted bioimaging. Colloids Surf B Biointerfaces. 2020 Apr;188:110785. doi: 10.1016/j.colsurfb.2020.110785. Epub 2020 Jan 9. PMID: 31951930.
25. Gadhave K, Gehi BR, Kumar P, Xue B, Uversky VN, Giri R. The dark side of Alzheimer's disease: unstructured biology of proteins from the amyloid cascade signaling pathway. Cell Mol Life Sci. 2020 Oct;77(20):4163-4208. doi: 10.1007/s00018-019-03414-9. Epub 2020 Jan 2. PMID: 31894361.
26. Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes. Front Pharmacol. 2019 Apr 24;10:288. doi: 10.3389/fphar.2019.00288. PMID: 31068802; PMCID: PMC6491817.
27. Kumar V, Gour S, Verma N, Kumar S, Gadhave K, Mishra PM, Goyal P, Pandey J, Giri R, Yadav JK. The mechanism of phosphatidylcholine-induced interference of PAP (248-286) aggregation. J Pept Sci. 2019 Apr;25(4):e3152. doi: 10.1002/psc.3152. Epub 2019 Feb 19. PMID: 30784133.
28. Gour S, Kumar V, Singh A, Gadhave K, Goyal P, Pandey J, Giri R, Yadav JK. Mammalian antimicrobial peptide protegrin-4 self assembles and forms amyloid- like aggregates: Assessment of its functional relevance. J Pept Sci. 2019 Mar;25(3):e3151. doi: 10.1002/psc.3151. Epub 2019 Feb 3. PMID: 30714272.
29. Kalita P, Shukla H, Gadhave K, Giri R, Tripathi T. Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase. Arch Biochem Biophys. 2018 Oct 15;656:38-45. doi: 10.1016/j.abb.2018.09.002. Epub 2018 Sep 8. PMID: 30205085.
30. Kalita J, Shukla R, Shukla H, Gadhave K, Giri R, Tripathi T. Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica. Sci Rep. 2017 Dec 13;7(1):17547. doi: 10.1038/s41598-017-17678-3. PMID: 29235505; PMCID: PMC5727538.
31. Pardeshi R, Bolshette N, Gadhave K, Ahire A, Ahmed S, Cassano T, Gupta VB, Lahkar M. Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease. Psychoneuroendocrinology. 2017 Sep;83:159-171. doi: 10.1016/j.psyneuen.2017.05.004. Epub 2017 May 30. PMID: 28624654.
32. Gadhave K, Bolshette N, Ahire A, Pardeshi R, Thakur K, Trandafir C, Istrate A, Ahmed S, Lahkar M, Muresanu DF, Balea M. The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease. J Cell Mol Med. 2016 Jul;20(7):1392-407. doi: 10.1111/jcmm.12817. Epub 2016 Mar 29. PMID: 27028664; PMCID: PMC4929298.
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