Antoni William James
  • Research Associate, University of Toledo
Research fields
  • Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Lipids and Lipoproteins
Personal information

Education

Ph.D, Bharathidasan University, 2017

Lab information

Prof. Zahoor A Shah's lab
https://www.utoledo.edu/pharmacy/depts/mbc/faculty-zshah.html

Publications

https://www.ncbi.nlm.nih.gov/myncbi/william%20james.antonisamy.1/bibliography/public/
1. Shehjar F, James AW, Mahajan R, Shah ZA. Inhibition of iron-induced cofilin activation and inflammation in microglia by a novel cofilin inhibitor. J Neurochem. 2024 Nov 18. doi: 10.1111/jnc.16260. Epub ahead of print. PMID: 39556452.

2. Hasan, Syed-Abdul-Moiz, Antonisamy William James, Farzeen M. Fazili, Samiha Tarabishi, Namir M. Sheikh, and Zahoor A. Shah. 2024. "Endoplasmic Reticulum Stress in Neurodegenerative Diseases" Journal of Dementia and Alzheimer's Disease 1, no. 2: 87-97. https://doi.org/10.3390/jdad1020006

3.SM Rashid, R Razak, AK Tantray, Antonisamy W.J, N Showkat, F Shehjar. Unraveling Alzheimer’s: Exploring the Gut Microbiota–Brain Axis as a New Frontier in Understanding
Journal of Dementia and Alzheimer's Disease 1 (1), 22-47

4.Antonisamy W.J, Bahader GA, Albassan M, Shah ZA. (2023). The ER chaperone, BIP protects Microglia from ER stress-mediated Apoptosis in Hyperglycemia. Neurochem Int.169:105573.

5. Bahader GA, Antonisamy W.J, Almarghalani DA, Shah ZA. (2023). Cofilin Inhibitor Protects against Traumatic Brain Injury-Induced Oxidative Stress and Neuroinflammation. Biology (Basel). 21; 12 (4):630. PMCID: PMC10136258

6. Yatoo MI, Bahader GA, Beigh SA, Khan AM, Antonisamy W.J, Asmi MR, Shah ZA. (2023).
Neuroprotection of Sex Bias: A Protective Response to Traumatic Brain Injury in the Females.CNS
Neurol Disord Drug Targets.10.2174.

7. Karaj E, Sindi SH, Kuganesan N, Koranne RA, Knoff JR, Antonisamy W.J, Fu Y, Kotsull LN, Pflum
MK, Shah Z, Taylor WR, Tillekeratne LMV. First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor
Hybrids. J Med Chem. 2022 Nov 10;65(21):14764-14791. doi: 10.1021/acs.jmedchem.

8. Shehjar F, Maktabi B, Rahman ZA, Bahader GA, Antonisamy W.J, Naqvi A, Mahajan R, Shah ZA.
(2023) Stroke: Molecular mechanisms and therapies: Update on recent developments. Neurochem
Int.162:105458. PMCID: PMC9839659.

9. Shoaib Manzoor, DaniyahA. Almarghalani, Antonisamy W.J, Md Kausar Raza,Nasimul Hoda, Zahoor A. Shah. Synthesis, Crystal Structure, and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents. ACS Chemical Neuroscience, 2022.

10. Bhanupriya Nagaraj, AntonisamyW J, Vasanthi Nachiappan. Impairment of RPN4 an ERAD
transcription factor causes lipid abnormality and ER stress in Saccharomyces Cerevisiae. Mol Cell
Biochem, 2023.

11. Iqbal J, Suarez MD, Yadav PK, Walsh MT, Li Y, Wu Y, Huang Z, Antonisamy.W.J, Escobar V, Mokbe
A, Brickman AM, Luchsinger JA, Dai K, Moreno H, Hussain MM. (2022). ATP-binding cassette protein
ABCA7 deficiency impairs sphingomyelin synthesis, cognitive discrimination, and synaptic plasticity in
the entorhinal cortex. J Biol Chem. 298(10):102411. 10.1016

12. Subitha. M, Antonisamy.W.J, Sivaprakasam .C, Nachiappan. V. (2020). Disruption in phosphate
transport affects membrane lipid and lipid droplet homeostasis in Saccharomyces cerevisiae. J Bioenerg Biomembr, 52(4):215-227.

13. Osman M. A, Antonisamy. W.J and Evgeny Yakirevich. (2020). IQGAP1 control of centrosome Function defines distinct variants of triple-negative breast cancer. Oncotarget, 11:2493-251.

14. Antonisamy.W. J, Ravi. C, Srinivasan. M, Nachiappan. V. (2019). Crosstalk between protein n-glycosylation and lipid metabolism in Saccharomyces cerevisiae. Sci Rep, 9; 9(1):14485.

15. Irani. S, Iqbal. J, Antonisamy.W. J, Ijaz. L, Hussain. MM. (2018). MicroRNA-30 reduces plasma
cholesterol in homozygous familial hypercholesterolemic and type-2 diabetic mouse models. J Lipid Res, 59(1):144-154.

16. Antonisamy.W.J, Gowsalya. R, Nachiappan. V. (2016). Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae. Biochim Biophys Acta, 1861(11):1705-1718.

17. Antonisamy.W.J, Nachiappan. V. (2014). Phosphate transporter-mediated lipid accumulation in
Saccharomyces cerevisiae under phosphate starvation conditions. Bioresour Technol,151:100-5
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.