• Research scientist, William Harvey Research Institute, Queen Mary University , London, UK
Research fields
  • Molecular Biology
Personal information


BSc, Polytechnic of East London, 1990

Lab information

Magdi Yaqoob Lab

Research focus

Renal, cardiovascular


Gut Dysbiosis in Experimental Kidney Disease: A Meta-Analysis of Rodent Repository Data.
Randall DW, Kieswich J, Hoyles L, McCafferty K, Curtis M, Yaqoob MM.J Am Soc Nephrol. 2023 Apr 1;34(4):533-553. doi: 10.1681/ASN.0000000000000071.

Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues.
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli-Berg F, Virgintino D, Solito E.FASEB J. 2022 Jan;36(1):e22107. doi: 10.1096/fj.202101297R..

Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome. Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM.Bio Protoc. 2020 Sep 20;10(18):e3751. doi: 10.21769/BioProtoc.3751. eCollection 2020 Sep 20.PMID: 33659410

Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice. Alliouachene S, Kieswich JE, Bilanges B, McCafferty K, Thiemermann C, Vanhaesebroeck B, Yaqoob MM.Am J Transplant. 2020 Dec 28. doi: 10.1111/ajt.16470. Online ahead of print.PMID: 33370494

Ergocalciferol improves endothelial vasodilatory and vasoconstrictor function in an in vivo model of mild uraemia. Dreyer G, Kieswich J, Harwood S, Ahluwalia A, Yaqoob MM.Biosci Rep. 2019 Dec 20;39(12):BSR20190711. doi: 10.1042/BSR20190711.PMID: 31789348

Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: a cautionary tale. Randall DW, Kieswich J, Swann J, McCafferty K, Thiemermann C, Curtis M, Hoyles L, Yaqoob MM.Microbiome. 2019 Sep 2;7(1):127. doi: 10.1186/s40168-019-0738-y.PMID: 31477171

The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling. Andrikopoulos P, Kieswich J, Pacheco S, Nadarajah L, Harwood SM, O'Riordan CE, Thiemermann C, Yaqoob MM.J Am Soc Nephrol. 2019 Jan;30(1):33-49. doi: 10.1681/ASN.2018020209. Epub 2018 Dec 10.PMID: 30530834

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain. Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C, Yaqoob MM.BMC Nephrol. 2018 Dec 4;19(1):346. doi: 10.1186/s12882-018-1155-3.PMID: 30509210

Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment. Kieswich J, Sayers SR, Silvestre MF, Harwood SM, Yaqoob MM, Caton PW.Diabetologia. 2016 Nov;59(11):2477-2486. doi: 10.1007/s00125-016-4076-3. Epub 2016 Aug 19.PMID: 27541013

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation. Bagnati M, Ogunkolade BW, Marshall C, Tucci C, Hanna K, Jones TA, Bugliani M, Nedjai B, Caton PW, Kieswich J, Yaqoob MM, Ball GR, Marchetti P, Hitman GA, Turner MD.Cell Death Dis. 2016 Aug 11;7(8):e2329. doi: 10.1038/cddis.2016.203.PMID: 27512950

IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD.
Chen J, Kieswich JE, Chiazza F, Moyes AJ, Gobbetti T, Purvis GS, Salvatori DC, Patel NS, Perretti M, Hobbs AJ, Collino M, Yaqoob MM, Thiemermann C.J Am Soc Nephrol. 2017 Jan;28(1):94-105. doi: 10.1681/ASN.2015060670. Epub 2016 May 6.PMID: 27153924

Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M, Solito E.Brain Behav Immun. 2016 Jan;51:212-222. doi: 10.1016/j.bbi.2015.08.020. Epub 2015 Aug 29.PMID: 26321046

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger. Andrikopoulos P, Kieswich J, Harwood SM, Baba A, Matsuda T, Barbeau O, Jones K, Eccles SA, Yaqoob MM.J Biol Chem. 2015 Jul 24;290(30):18412-28. doi: 10.1074/jbc.M114.628156. Epub 2015 May 15.PMID: 25979335

A key role for interferon regulatory factors in mediating early-life metabolic defects in male offspring of maternal protein restricted rats. Silvestre MF, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC, Caton PW.Horm Metab Res. 2014 Apr;46(4):252-8. doi: 10.1055/s-0034-1370933. Epub 2014 Mar 13.PMID: 24627105

Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Chapagain A, Caton PW, Kieswich J, Andrikopoulos P, Nayuni N, Long JH, Harwood SM, Webster SP, Raftery MJ, Thiemermann C, Walker BR, Seckl JR, Corder R, Yaqoob MM.Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3817-22. doi: 10.1073/pnas.1312436111. Epub 2014 Feb 25.PMID: 24569863

The effect of uraemia on the duration of arrhythmias in the context of cardioprotective ischaemic conditioning strategies. McCafferty K, Byrne CJ, Kieswich J, Raftery M, Thiemermann C, Yaqoob MM.Heart Asia. 2014 May 24;6(1):76-82. doi: 10.1136/heartasia-2013-010432. eCollection 2014.PMID: 27326175

Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Coldewey SM, Khan AI, Kapoor A, Collino M, Rogazzo M, Brines M, Cerami A, Hall P, Sheaff M, Kieswich JE, Yaqoob MM, Patel NS, Thiemermann C.Kidney Int. 2013 Sep;84(3):482-90. doi: 10.1038/ki.2013.118. Epub 2013 Apr 17.PMID: 23594675

Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC.Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.PMID: 23397292

Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.
Petrie JL, Al-Oanzi ZH, Arden C, Tudhope SJ, Mann J, Kieswich J, Yaqoob MM, Towle HC, Agius L.Mol Cell Biol. 2013 Feb;33(4):725-38. doi: 10.1128/MCB.01576-12. Epub 2012 Dec 3.PMID: 23207906

Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction.
Byrne CJ, McCafferty K, Kieswich J, Harwood S, Andrikopoulos P, Raftery M, Thiemermann C, Yaqoob MM.Circulation. 2012 Mar 13;125(10):1256-65. doi: 10.1161/CIRCULATIONAHA.111.055392. Epub 2012 Feb 8.PMID: 22319109

A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5. Tudhope SJ, Wang CC, Petrie JL, Potts L, Malcomson F, Kieswich J, Yaqoob MM, Arden C, Hampson LJ, Agius L.Diabetes. 2012 Jan;61(1):49-60. doi: 10.2337/db11-0870. Epub 2011 Nov 21.PMID: 22106156

A possible explanation for anemia in patients treated with mycophenolic acid. Pile T, Kieswich J, Harwood S, Yaqoob MM.Transplantation. 2011 Dec 27;92(12):1316-21. doi: 10.1097/TP.0b013e318238da98.PMID: 22075530

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Caton PW, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC.Diabetologia. 2011 Dec;54(12):3083-92. doi: 10.1007/s00125-011-2288-0. Epub 2011 Sep 8.PMID: 21901281

Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.
Caton PW, Kieswich J, Yaqoob MM, Holness MJ, Sugden MC.Diabetes Obes Metab. 2011 Dec;13(12):1097-104. doi: 10.1111/j.1463-1326.2011.01466.x.PMID: 21733059

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.
Caton PW, Nayuni NK, Kieswich J, Khan NQ, Yaqoob MM, Corder R.J Endocrinol. 2010 Apr;205(1):97-106. doi: 10.1677/JOE-09-0345. Epub 2010 Jan 21.PMID: 20093281

Dexamethasone ameliorates renal ischemia-reperfusion injury. Kumar S, Allen DA, Kieswich JE, Patel NS, Harwood S, Mazzon E, Cuzzocrea S, Raftery MJ, Thiemermann C, Yaqoob MM.J Am Soc Nephrol. 2009 Nov;20(11):2412-25. doi: 10.1681/ASN.2008080868. Epub 2009 Sep 24.PMID: 19797168

Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Tripatara P, Patel NS, Collino M, Gallicchio M, Kieswich J, Castiglia S, Benetti E, Stewart KN, Brown PA, Yaqoob MM, Fantozzi R, Thiemermann C.Lab Invest. 2008 Oct;88(10):1038-48. doi: 10.1038/labinvest.2008.73. Epub 2008 Aug 4.PMID: 18679378

Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells. Ashman N, Harwood SM, Kieswich J, Allen DA, Roberts NB, Mendes-Ribeiro AC, Yaqoob MM.Kidney Int. 2005 May;67(5):1878-89. doi: 10.1111/j.1523-1755.2005.00286.x.PMID: 15840035

Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. Sharples EJ, Patel N, Brown P, Stewart K, Mota-Philipe H, Sheaff M, Kieswich J, Allen D, Harwood S, Raftery M, Thiemermann C, Yaqoob MM.J Am Soc Nephrol. 2004 Aug;15(8):2115-24. doi: 10.1097/01.ASN.0000135059.67385.5D.PMID: 15284297
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