Sumeet Nayak
  • Senior Scientist, KSQ Therapeutics, Inc
Research fields
  • Cancer Biology, Cell Biology, Molecular Biology
Personal information


Ph.D., University of Massachusetts Medical School, 2020

Lab information

Sharon Cantor Lab

Research focus

DNA damage and repair, Replication stress and stress response, Cancer therapy response


• Nayak, S., and Cantor, S. B. S1 nuclease fiber assay. Bio-protocol (2020).
• Nayak, S., and Cantor, S. B. Immunofluorescence staining protocol to detect ssDNA (CldU) and active replication (EdU). Bio-protocol (2020).
• Nayak, S., Calvo, J.A., Cong, K., Peng, M., Berthiaume, E., Jackson, J., Zaino, A.M., Vindigni, A., Hadden, M.K., and Cantor, S.B. Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability. Science Advances (2020).
• Awate, S., Sommers, J.A., Datta, A., Nayak, S., Bellani, M.A., Yang, O., Dunn, C.A., Nicolae, C.M., Moldovan, G-L., Seidman, M.M., Cantor, S.B., and Brosh, Jr. R.M. FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links. Nucleic Acid Research (2020).
• Panzarino, N.J., Krais, J., Peng, M., Mosqueda, M., Nayak, S., Bond, S., Calvo, J., Cong, K., Doshi, M., Bere, M., et al. Replication gaps underlie BRCA-deficiency and therapy response. (2019). bioRxiv, 781955. (Under revision at Cancer Research).
• Cong, K., Kousholt, A.N., Peng, M., Panzarino, N.J., Lee, W.T.C., Nayak, S., Krais, J., Calvo, J., Bere, M., Rothenberg, E., et al. PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps. (2019). bioRxiv, 781989. (In preparation).
• Fuhrmann, C., Fenn, S.L., Hidalgo, D., Horowitz, B.B., Loring, H.S., Nayak, S., Spears, M.E., Weaver, G.C., & Lane, M.E. Creating the “new normal”: Career development embedded into the Ph.D. curriculum for all trainees. Book chapter “BEST: Implementing Career Development Activities for Biomedical Research Trainees (2020).
• Peng, M., Cong, K., Panzarino, N. J., Nayak, S., Calvo, J., Deng, B., Zhu, L. J., Morocz, M., Hegedus, L., Haracska, L., and Cantor, S. B. Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication During Stress. Cell reports (2018).
• Cantor, S.B., and Nayak, S. FANCJ at the FORK. Mutation research (2016).
• Jacob, S., Nayak, S., Chaudhari, U.K., Joshi, D., Vundinti, B.R., Fernandes, G., Barai, R.S., Kholkute, S.D., and Sachdeva, G. A triad of telomerase, androgen receptor and early growth response 1 in prostate cancer cells. Cancer Biology and Therapy (2016).
• Jacob, S., Nayak,S., Fernandes, G., Barai, R.S., Menon, S., Chaudhari, U.K., Kholkute, S.D., and Sachdeva, G. Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer. Endocrine Related Cancer (2014).
• Bhagwat, S.R., Redij, T., Phalnikar, K., Nayak, S., Iyer, S., Gadkar, S., Chaudhari, U.K., Kholkute, S.D., and Sachdeva, G. Cell Surfactomes of Two Endometrial Epithelial Cell lines that differ in their Adhesiveness to Embryonic Cells. Molecular Reproduction & Development (2014).
• Bhagwat, S.R., Chandrashekar, D.S., Kakar, R., Davuluri, S., Bajpai, A.K., Nayak, S., Bhutada, S., Acharya, K., and Sachdeva, G. Endometrial Receptivity: A Revisit to Functional Genomics Studies on Human Endometrium and Creation of HGEx-ERdb. PLoS one (2013).
• Navalakhe, R.M., Jagtap, D.D., Nayak, S., Nandedkar, T.D., and Mahale, S.D. Effect of FSH Receptor-Binding Inhibitor-8 on FSH-Mediated Granulosa Cell Signaling and Proliferation. Chemical Biology and Drug Design (2013).
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