Giacomo Frati
  • Post-Doc, Chromatin and gene regulation upon differentiation Imagine Institute
Research fields
  • Stem Cell
Personal information


PhD in Molecular medicine, University Vita-Salute San Raffaele, 2016


Chalumeau, A, Frati G, Miccio A. Reverse phase (RP)-high-performance liquid chromatography (HPLC) analysis of globin chains. Bio-protocol (2020).

El Hoss S, Cochet S, Godard A, Yan H, Dussiot M, Frati G, Boutonnat-Faucher B, Laurance S, Renaud O, Joseph L, Miccio A, Brousse V, Mohandas N, El Nemer W. Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease Haematologica (2020)

Frati G Miccio A. A genome-editing system for therapeutical targeting of stem cells. Chapter in the volume entitled “Leukemic Stem Cells”, Methods in Molecular Biology. Doi:

Weber L*, Frati G*; Felix T, Hardouin G, Casini A, Wollenschlaeger C, Meneghini V, Masson C, De Cian A, Chalumeau A, Mavilio F, Amendola M, Andre-Schmutz I, Cereseto A, El Nemer W, Concordet JP, Giovannangeli C, Cavazzana M, Miccio A. Editing a γ-Globin Repressor Binding Site Restores Fetal Hemoglobin Synthesis and Corrects the Sickle Cell Disease Phenotype Science Advances (2020), 6 (7), eaay9392.

* Contributed equally

Tykesson E, Hassinen A, Zielinska K, Thelin MA, Frati G, Ellervik U, Westergren-Thorsson G, Malmström A, Kellokumpu S, Maccarana M. Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks. J. Biol. Chem. jbc.RA118.003875 (2018). doi:10.1074/jbc.RA118.003875

Frati G, Luciani M, Meneghini V, De Cicco S, Ståhlman M, Blomqvist M, Grossi S, Filocamo M, Morena F, Menegon A, Martino S, Gritti A. Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy. Cell Death Dis. 9, (2018)

Meneghini V*, Frati G*, Sala D, De Cicco S, Luciani M, Cavazzin C, Paulis M, Mentzen W, Morena F, Giannelli S, Sanvito F, Villa A, Bulfone A, Broccoli V, Martino S, Gritti A. Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy. STEM CELLS Transl. Med. 6, 352–368 (2017).

*Contributed equally
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