Jeanene de Avila Washington State University
1 protocol

Mei-Jun Zhu Washington State University Pullman
1 protocol

Jun Son Washington State University Pullman
1 protocol

Song Chae Washington State University Pullman
1 protocol

Min Du
  • Professor and Endowed Chair in Nutrigenomics and Growth Biology, Department of Animal Sciences, Washington State University (WSU), Pullman, WA
Research focus
  • Developmental biology
  • 1 Author merit


PhD, Iowa State University, Ames, IA, 2001


Selected publications in the last 5 years
1. Chen, Y. T., Y. Hu, Q. Y. Yang, X. D. Liu, J. S. Son, J. M. de Avila, M. J. Zhu, and M. Du. (2020). Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1. Science Bulletin, In press.
2. Chen, Y.T., Y. Hu, Q.Y. Wang, J.S. Son, X.D. Liu, J.M. de Avila, M. J. Zhu, and M. Du. (2020). Excessive glucocorticoids during pregnancy impair fetal brown fat development and predisposes offspring to metabolic dysfunctions. Diabetes, 69: 1662-1674.
3. Tian, Q., Z. Xu, X. Sun, J. Deavila, M. Du, and M. J. Zhu. (2020). Grape pomace inhibits colon carcinogenesis by suppressing cell proliferation and inducing epigenetic modifications. Journal of Nutritional Biochemistry, 84: 108443.
4. Tian Q.Y., X.D. Liu, and M. Du. (2020). Alpha-ketoglutarate for adipose tissue rejuvenation. Aging, 12: 13845-13846.
5. Hu, Y., Y. Feng, L. Zhang, Y. Jia, D. Cai, S.B. Qian, M. Du, and R. Zhao. (2020). GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. RNA Biology, 17: 930-942.
6. Sun, J., L. Zhao, Y. Chen, K. Chen, S. A. Chae, J. M. de Avila, H. Wang, M.J. Zhu, Z. Jiang, and M. Du. (2020). Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice. Science Advances, 6: eaaz0359.
7. Li, T., H. Gong, Q. Yuan, M. Du, F. Ren, and X. Mao. (2020). Supplementation of polar lipids-enriched milk fat globule membrane in high fat diet fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring. FASEB Journal, 34: 4619-4634.
8. Yuan, Q., B. Zhan, R. Chang, M. Du, and X. Mao. (2020). Antidiabetic effect of casein glycomacropeptide hydrolysates on high-fat diet and STZ-induced diabetic mice via regulating insulin signaling in skeletal muscle and modulating gut microbiota. Nutrients, 12: E220.
9. Tian, Q., J. Zhao, Q. Yang, B. Wang, J. Deavila, M.J. Zhu, and M. Du. (2020). Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. Aging Cell, 19: e13059.
10. Zhao, L., B. Wang, N. Gomez, J. Deavila, M. J. Zhu, and M. Du. (2020). Even a Low Dose of Tamoxifen Profoundly Induces Adipose Tissue Browning in Female Mice. International Journal of Obesity, 44,226-234.
11. insulin resistance by blocking serine palmitoyltransferase 3-mediated ceramide biosynthesis. Nutrients, 11: 1185.
12. Son, J., X. Liu, Q. Tian, L. Zhao, Y. Chen, Y. Hu, S. A. Chae, J. M. Deavila, M. J. Zhu, and M. Du. (2019). Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth. Journal of Physiology, 597: 3333-3347.
13. Wang, H., Y. Chen, X. Mao, and M. Du. (2019). Maternal obesity impairs fetal mitochondriogenesis and brown adipose tissue development partially via upregulation of miR-204-5p. BBA-Molecular Basis of Disease, 1865: 2706-2715.
14. Wang, H., X. Mao, and M. Du. (2019). Phytanic acid activates PPARa to promote beige adipogenic differentiation of preadipocytes. Journal of Nutritional Biochemistry, 67: 201-211.
15. Han, L., T. Li, M. Du, R. Chang, B. Zhan, and X. Mao. (2019). Beneficial effects of Potentilla discolor Bunge water extract on inflammatory cytokines release and gut microbiota in high-fat diet and streptozotocin-induced type 2 diabetic mice. Nutrients, 11: E670.
16. Son, J.S., S.A. Chae, B.I. Park, M. Du, W. Song. (2019). Plasma apelin levels in overweight/obese adults following a single bout of exhaustive exercise: A preliminary cross-sectional study. Endocrinologia, Diabetes y Nutricion, 66: 278-290.
17. Xue, Y., M. Du, and M. J. Zhu. (2019). Raspberry extract prevents Escherichia coli O157:H7-induced NLRP3 inflammasome activation. Journal of Functional Food, 56: 224-231.
18. Zhao, L., M. Du, J. Gao, B. Zhan, and X. Mao, (2019). Label-free quantitative proteomic analysis of milk fat globule membrane proteins of yak and cow and identification of proteins associated with glucose and lipid metabolism. Food Chemistry, 275: 59-68.
19. Chen, Y., Y. Yang, and M. Du. (2018). Beyond brown adipogenesis the inheritance of imprinted H19. Non-coding RNA Investigation, 2:64.
20. Wang, B., C. L. Harris, W. Nie, X. Fu, J. M. Deavila, M. J. Zhu, M. Maquivar, S. M. Parish, J. R. Busboom, M. L. Nelson, and M. Du. (2018). Neonatal vitamin A injection promotes cattle muscle development and increase oxidative muscle fibers. Journal of Animal Science and Biotechnology, 9: 82.
21. Zhu, M.J., X. Sun, and M. Du. (2018). AMPK in regulation of apical junctions and barrier junction of intestinal epithelium. Tissue Barriers, 6: 1-13.
22. McCallum, M. L., C. A. Pru, A. R. Smith, N. C. Kelp, N. Foretz, B. Viollet, M. Du, and J. Pru. (2018). A functional role of AMPK in female fertility and endometrial regeneration. Reproduction, 156: 501-513.
23. Li, T., J. Gao, M. Du, J. Song, and X. Mao. (2018). Milk fat globule membrane attenuates high-fat diet-induced obesity by inhibiting adipogenesis and increasing uncoupling protein 1 expression in white adipose tissue of mice, Nutrients, 10: 331.
24. Zou, T., B. Wang, Q. Yang, J. M. de Avila, M. J. Zhu, J. You, D. Chen, and M. Du. (2018). Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) 1. Journal of Nutritional Biochemistry, 55: 157.
25. Sun, X., X. Fu, M. Du, and M. J. Zhu. (2018). Ex vivo gut culture for tracing gut epithelial development. Open Biology, 8: 170256.
26. Sun, X., M. Du, D. A. Navarre and M. J. Zhu. (2018). Purple potato extract promotes intestinal epithelial differentiation and barrier function by activating AMP-activated protein kinase. Molecular Nutrition and Food Research, 62: 1700536.
27. Maricelli, J. A., Y. M. Bishaw, B. Wang, M. Du, and B. D. Rodgers. (2018). Systemic SMAD7 gene therapy increases striated muscle mass and enhances exercise capacity in a dose-dependent manner. Human Gene Therapy, 29: 390-399.
28. Zhu, M. J., Kang, Y., Y. Xue, X. Liang, M. P. Gonzalez Carcia, D. Rodgers, D. K. Kagel, and M. Du. (2018). Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice. Journal of Nutritional Biochemistry, 53:96-103.
29. Wang, B., X. Fu, X. Liang, J. M. Deavila, Z. Wang, L. Zhao, Q. Tian, J. Zhao, N. A. Gomez, S. C. Trombetta, M. J. Zhu, and M. Du. (2017). Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRa+ adipose progenitors. Cell Discovery, 3:17036.
30. Wang, B., Z. Wang, J. M. de Avila, M. J. Zhu, F. Zhang, N. A. Gomez, L. Zhao, Q. Tian, J. Zhao, J. Maricelli, H. Zhang, B. D. Rodgers, and M. Du. (2017). Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB Journal, 31: 4612-4622.
31. Wang, B., X. Fu, M.J. Zhu, and M. Du. (2017). Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation. Journal of Molecular Cell Biology, 9: 338-349.
32. Zhao, J., Q. Yang, L. Zhang, X. Liang, X. Sun, B. Wang, Y. Chen, M. J. Zhu, and M. Du. (2017). AMPKa1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochemical and Biophysical Research Communications, 491: 508-514.
33. Sun, X. X. Fu, Q. Y. Yang, M. Du, and M. J. Zhu. (2017). AMPK regulate intestinal differentiation via histone modification of CDX2. Cell Death and Differentiation, 24: 819-831.
34. Wang, S., X. Liang, Q. Yang, X. Fu, M. Zhu, B.D. Rodgers, Q. Jiang, M. V. Dodson, and M. Du. (2017). Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) 1 in mice fed high-fat diet. Molecular Nutrition and Food Research, 61: 1600746.
35. Wang B., X. Fu, X. Liang, Z. Wang, Q. Yang, T. Zou, W. Nie, J. Zhao, P. Gao, M. J. Zhu, J. M. De Avila, J. Maricelli, B. D. Rodgers, and M. Du. (2017). Maternal retinoids increase PDGFRa progenitor population and beige adipogenesis in progeny by stimulating vascular development. EBioMedicine, 18:288-299.
36. Zou, T., Q. Yang, B. Wang, M. Zhu, P. W. Nathanielsz, and M. Du. (2017). Resveratrol supplementation to high fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. Journal of Physiology, 595: 1547-1562.
37. Liang, X. W., Q. Y. Yang, L. P. Zhang, J. Maricelli, B. D. Rodgers, M. J. Zhu, and M. Du (2016). Maternal high-fat diet during lactation impairs thermogenic function of brown adipose tissue in offspring mice. Scientific Reports, 6: 34345.
38. Yang, Q., X. Liang, X. Sun, L. Zhang, X. Fu, C. J. Rogers, A. Berim, S. Zhang, S. Wang, B. Wang, M. Foretz, B. Viollet, D. R. Gang, B. D. Rodgers, M. Zhu, and M. Du. (2016). AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis. Cell Metabolism, 24: 542-554.
39. Liang, X., Q. Yang, X. Fu, C. J. Rogers, B. Wang, H. Pan, M. J. Zhu, P. W. Nathanielsz, and M. Du. (2016). Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. Journal of Physiology, 594: 4453-4466.
40. Li, N., Q. Y. Yang, R. Walker, T.B. Thompson, M. Du, and B. R. Rodgers. (2016). Myostatin attenuation in vivo reduces adiposity, but activates adipogenesis. Endocrinology, 157: 282-291.
41. Fu, X., M. J. Zhu, S. Zhang, F. Marc, V. Benoit, and M. Du. (2016). Obesity impairs skeletal muscle regeneration via inhibition of AMP-activated protein kinase. Diabetes. 65: 188-200.
1 Protocol published
Treadmill Running of Mouse as a Model for Studying Influence of Maternal Exercise on Offspring
Authors:  Song Ah Chae, Jun Seok Son, Mei-Jun Zhu, Jeanene M. de Avila and Min Du, date: 12/05/2020, view: 2502, Q&A: 0

Epidemiological studies robustly show the beneficial effects of maternal exercise in reducing maternal birth complications and improving neonatal outcomes, though underlying mechanisms remain poorly understood. To facilitate mechanistic exploration,

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