Sheng-Yang Wu National Taiwan University College of Medicine
1 protocol

Betty A. Wu-Hsieh
  • Professor, National Taiwan University
Research focus
  • Immunology
  • 1 Author merit


PhD, University of California, Los Angeles, USA


Since 2010
• Wu, S. Y., Weng, C. L., Jheng, M. J., Kan, H. W., Hsieh, S. T., Liu, F. T. and Wu-Hsieh, B. A. (2019). Candida albicans triggers NADPH oxidase-independent neutrophil extracellular traps through dectin-2. PLoS Pathog 15(11): e1008096.
• Sri-In, C., Weng, S. C., Chen, W. Y., Wu-Hsieh, B. A., Tu, W. C. and Shiao, S. H. (2019). A salivary protein of Aedes aegypti promotes dengue-2 virus replication and transmission. Insect Biochem Mol Biol 111: 103181.
• Chen, W. Y., Wu, S. Y., Lin, T. C., Lin, S. L. and Wu-Hsieh, B. A. (2019). Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis. Cell Mol Immunol 16(3): 288-301.
• Huang, J. H., Liu, C. Y., Wu, S. Y., Chen, W. Y., Chang, T. H., Kan, H. W., Hsieh, S. T., Ting, J. P. and Wu-Hsieh, B. A. (2018). NLRX1 Facilitates Histoplasma capsulatum-Induced LC3-Associated Phagocytosis for Cytokine Production in Macrophages. Front Immunol 9: 2761.
• Wan, S. W., Wu-Hsieh, B. A., Lin, Y. S., Chen, W. Y., Huang, Y. and Anderson, R. (2018). The monocyte-macrophage-mast cell axis in dengue pathogenesis. J Biomed Sci 25(1): 77.
• Pathak, N., Lai, M. L., Chen, W. Y., Hsieh, B. W., Yu, G. Y. and Yang, J. M. (2017). Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection. BMC Bioinformatics 18(Suppl 16): 548.
• Lee, Y. H., Huang, J. H., Chang, T. H., Yang, H. C. and Wu-Hsieh, B. A. (2017). Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Positively Modulates Matrix Metalloproteinase-9 Production in Alveolar Macrophages upon Toll-Like Receptor 7 Signaling and Influenza Virus Infection. Front Immunol 8: 1177.
• Chang, T. H., Huang, J. H., Lin, H. C., Chen, W. Y., Lee, Y. H., Hsu, L. C., Netea, M. G., Ting, J. P. and Wu-Hsieh, B. A. (2017). Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum. PLoS Pathog 13(7): e1006485.
• Chu, Y. T., Wan, S. W., Chang, Y. C., Lee, C. K., Wu-Hsieh, B. A., Anderson, R. and Lin, Y. S. (2017). Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation. Lab Invest.
• Wu, S. Y., Huang, J. H., Chen, W. Y., Chan, Y. C., Lin, C. H., Chen, Y. C., Liu, F. T. and Wu-Hsieh, B. A. (2017). Cell Intrinsic Galectin-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation. Front Immunol 8: 48.
• Huang, J. H., Lin, C. Y., Wu, S. Y., Chen, W. Y., Chu, C. L., Brown, G. D., Chuu, C. P. and Wu-Hsieh, B. A. (2015). CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway. PLoS Pathog 11(7): e1004985.
• Lin, J. C., Lin, S. C., Chen, W. Y., Yen, Y. T., Lai, C. W., Tao, M. H., Lin, Y. L., Miaw, S. C. and Wu-Hsieh, B. A. (2014). Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193(3): 1258-1267.
• Wan, S. W., Lu, Y. T., Huang, C. H., Lin, C. F., Anderson, R., Liu, H. S., Yeh, T. M., Yen, Y. T., Wu-Hsieh, B. A. and Lin, Y. S. (2014). Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1. PLoS One 9(3): e92495.
• Lee, Y. H., Lai, C. L., Hsieh, S. H., Shieh, C. C., Huang, L. M. and Wu-Hsieh, B. A. (2013). Influenza A virus induction of oxidative stress and MMP-9 is associated with severe lung pathology in a mouse model. Virus Res 178(2): 411-422.
• Fermin Lee, A., Chen, H. Y., Wan, L., Wu, S. Y., Yu, J. S., Huang, A. C., Miaw, S. C., Hsu, D. K., Wu-Hsieh, B. A. and Liu, F. T. (2013). Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines. Am J Pathol 183(4): 1209-1222.
• Wu, S. Y., Yu, J. S., Liu, F. T., Miaw, S. C. and Wu-Hsieh, B. A. (2013). Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum. J Immunol 190(7): 3427-3437.
• Sung, J. M., Lee, C. K. and Wu-Hsieh, B. A. (2012). Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection. PLoS One 7(9): e46292.
• Hsu, S. C., Chang, C. P., Tsai, C. Y., Hsieh, S. H., Wu-Hsieh, B. A., Lo, Y. S. and Yang, J. M. (2012). Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes. Immunology 136(2): 139-152.
• Hu, W., Yen, Y. T., Singh, S., Kao, C. L. and Wu-Hsieh, B. A. (2012). SARS-CoV regulates immune function-related gene expression in human monocytic cells. Viral Immunol 25(4): 277-288.
• Hsieh, S. H., Lin, J. S., Huang, J. H., Wu, S. Y., Chu, C. L., Kung, J. T. and Wu-Hsieh, B. A. (2011). Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11): 4493-4502.
• Lee, H. C., Yen, Y. T., Chen, W. Y., Wu-Hsieh, B. A. and Wu, S. C. (2011). Dengue type 4 live-attenuated vaccine viruses passaged in vero cells affect genetic stability and dengue-induced hemorrhaging in mice. PLoS One 6(10): e25800.
• Lin, J. S., Huang, J. H., Hung, L. Y., Wu, S. Y. and Wu-Hsieh, B. A. (2010). Distinct roles of complement receptor 3, Dectin-1, and sialic acids in murine macrophage interaction with Histoplasma yeast. J Leukoc Biol 88(1): 95-106.
1 Protocol published
Neutrophil Extracellular Trap Killing Assay of Candida albicans
Authors:  Sheng-Yang Wu and Betty A. Wu-Hsieh, date: 08/20/2020, view: 4195, Q&A: 0
Fungal pathogen Candida albicans is one of the top leading causes of overall healthcare-associated bloodstream infections worldwide. Neutrophil is the major effector cell to clear C. albicans infection. Our study showed that ...
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