Patrizia Anna Gena
  • Researcher, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro", Bari, 2008-2020
Research fields
  • Biophysics
Personal information

Education

Ph.D. in Physiology, University of Bari “Aldo Moro”, Bari, Italy, 2006

Publications

• Centrone, M., Gena, P., Ranieri, M., Di Mise, A., D'Agostino, M., Mastrodonato, M., Venneri, M., De Angelis, D., Pavan, S., Pasqualone, A., Summo, C., Fanelli, V., Valenti, G., Calamita, G. and Tamma, G. (2020). In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation. Antioxidants (Basel) 9(3).
• Liu, S., Fukumoto, T., Gena, P., Feng, P., Sun, Q., Li, Q., Matsumoto, T., Kaneko, T., Zhang, H., Zhang, Y., Zhong, S., Zeng, W., Katsuhara, M., Kitagawa, Y., Wang, A., Calamita, G. and Ding, X. (2020). Ectopic expression of a rice plasma membrane intrinsic protein (OsPIP1;3) promotes plant growth and water uptake. Plant J 102(4): 779-796.
• Baldini, F., Portincasa, P., Grasselli, E., Damonte, G., Salis, A., Bonomo, M., Florio, M., Serale, N., Voci, A., Gena, P., Vergani, L. and Calamita, G. (2020). Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition. Biochim Biophys Acta Mol Cell Biol Lipids 1865(3): 158586.
• De Santis, S., Serino, G., Fiorentino, M. R., Galleggiante, V., Gena, P., Verna, G., Liso, M., Massaro, M., Lan, J., Troisi, J., Cataldo, I., Bertamino, A., Pinto, A., Campiglia, P., Santino, A., Giannelli, G., Fasano, A., Calamita, G. and Chieppa, M. (2019). Corrigendum: Aquaporin-9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells. Front Immunol 10: 216.
• Sonntag, Y., Gena, P., Maggio, A., Singh, T., Artner, I., Oklinski, M. K., Johanson, U., Kjellbom, P., Nieland, J. D., Nielsen, S., Calamita, G. and Rutzler, M. (2019). Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem 294(18): 7377-7387.
• Oudot, C., Gomes, A., Nicolas, V., Le Gall, M., Chaffey, P., Broussard, C., Calamita, G., Mastrodonato, M., Gena, P., Perfettini, J. L., Hamelin, J., Lemoine, A., Fischmeister, R., Vieira, H. L. A., Santos, C. N. and Brenner, C. (2019). CSRP3 mediates polyphenols-induced cardioprotection in hypertension. J Nutr Biochem 66: 29-42.
• De Santis, S., Serino, G., Fiorentino, M. R., Galleggiante, V., Gena, P., Verna, G., Liso, M., Massaro, M., Lan, J., Troisi, J., Cataldo, I., Bertamino, A., Pinto, A., Campiglia, P., Santino, A., Giannelli, G., Fasano, A., Calamita, G. and Chieppa, M. (2018). Aquaporin 9 Contributes to the Maturation Process and Inflammatory Cytokine Secretion of Murine Dendritic Cells. Front Immunol 9: 2355.
• Maggio, A., Bernardino, R. L., Gena, P., Alves, M. G., Oliveira, P. F. and Calamita, G. (2018). A Stopped-Flow Light Scattering Methodology for Assessing the Osmotic Water Permeability of Whole Sertoli Cells. Methods Mol Biol 1748: 279-286.
• Chiadak, J. D., Gena, P., Gregoire, F., Bolaky, N., Delforge, V., Perret, J., Calamita, G. and Delporte, C. (2017). Lipopolysaccharide Modifies Glycerol Permeability and Metabolism in 3T3-L1 Adipocytes. Int J Mol Sci 18(12).
• Cataldo, I., Maggio, A., Gena, P., de Bari, O., Tamma, G., Portincasa, P. and Calamita, G. (2019). Modulation of Aquaporins by Dietary Patterns and Plant Bioactive Compounds. Curr Med Chem 26(19): 3457-3470.
• Gena, P., Buono, N. D., D'Abbicco, M., Mastrodonato, M., Berardi, M., Svelto, M., Lopez, L. and Calamita, G. (2017). Dynamical modeling of liver Aquaporin-9 expression and glycerol permeability in hepatic glucose metabolism. Eur J Cell Biol 96(1): 61-69.
• Bernardino, R. L., Marinelli, R. A., Maggio, A., Gena, P., Cataldo, I., Alves, M. G., Svelto, M., Oliveira, P. F. and Calamita, G. (2016). Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends. Int J Mol Sci 17(7).
• Vilas, G., Krishnan, D., Loganathan, S. K., Malhotra, D., Liu, L., Beggs, M. R., Gena, P., Calamita, G., Jung, M., Zimmermann, R., Tamma, G., Casey, J. R. and Alexander, R. T. (2015). Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction. Mol Biol Cell 26(6): 1106-1118.
• Scalera, V., Gena, P., Mastrodonato, M., Kitagawa, Y., Carulli, S., Svelto, M. and Calamita, G. (2014). Functional reconstitution of a rice aquaporin water channel, PIP1;1, by a micro-batchwise methodology. Plant Physiol Biochem 85: 78-84.
• Rodriguez, A., Gena, P., Mendez-Gimenez, L., Rosito, A., Valenti, V., Rotellar, F., Sola, I., Moncada, R., Silva, C., Svelto, M., Salvador, J., Calamita, G. and Fruhbeck, G. (2014). Reduced hepatic aquaporin-9 and glycerol permeability are related to insulin resistance in non-alcoholic fatty liver disease. Int J Obes (Lond) 38(9): 1213-1220.
• Gena, P., Mastrodonato, M., Portincasa, P., Fanelli, E., Mentino, D., Rodriguez, A., Marinelli, R. A., Brenner, C., Fruhbeck, G., Svelto, M. and Calamita, G. (2013). Liver glycerol permeability and aquaporin-9 are dysregulated in a murine model of Non-Alcoholic Fatty Liver Disease. PLoS One 8(10): e78139.
• Muller-Lucks, A., Gena, P., Frascaria, D., Altamura, N., Svelto, M., Beitz, E. and Calamita, G. (2013). Preparative scale production and functional reconstitution of a human aquaglyceroporin (AQP3) using a cell free expression system. N Biotechnol 30(5): 545-551.
• Ding, X., Matsumoto, T., Gena, P., Liu, C., Pellegrini-Calace, M., Zhong, S., Sun, X., Zhu, Y., Katsuhara, M., Iwasaki, I., Kitagawa, Y. and Calamita, G. (2013). Water and CO2 permeability of SsAqpZ, the cyanobacterium Synechococcus sp. PCC7942 aquaporin. Biol Cell 105(3): 118-128.
• Liu, C., Fukumoto, T., Matsumoto, T., Gena, P., Frascaria, D., Kaneko, T., Katsuhara, M., Zhong, S., Sun, X., Zhu, Y., Iwasaki, I., Ding, X., Calamita, G. and Kitagawa, Y. (2013). Aquaporin OsPIP1;1 promotes rice salt resistance and seed germination. Plant Physiol Biochem 63: 151-158.
• Jelen, S., Gena, P., Lebeck, J., Rojek, A., Praetorius, J., Frokiaer, J., Fenton, R. A., Nielsen, S., Calamita, G. and Rutzler, M. (2012). Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 303(11): G1279-1287.
• Calamita, G., Gena, P., Ferri, D., Rosito, A., Rojek, A., Nielsen, S., Marinelli, R. A., Fruhbeck, G. and Svelto, M. (2012). Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol. Biol Cell 104(6): 342-351.
• Lebeck, J., Gena, P., O'Neill, H., Skowronski, M. T., Lund, S., Calamita, G. and Praetorius, J. (2012). Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation. Am J Physiol Gastrointest Liver Physiol 302(3): G365-374.
• Gena, P., Calamita, G. and Guggino, W. B. (2010). Cadmium impairs albumin reabsorption by down-regulating megalin and ClC5 channels in renal proximal tubule cells. Environ Health Perspect 118(11): 1551-1556.
• Liquori, G. E., Mastrodonato, M., Rossi, R., Scillitani, G., Gena, P., Portincasa, P., Calamita, G. and Ferri, D. (2010). Altered membrane glycoprotein targeting in cholestatic hepatocytes. Eur J Clin Invest 40(5): 393-400.
• Gena, P., Fanelli, E., Brenner, C., Svelto, M. and Calamita, G. (2009). News and views on mitochondrial water transport. Front Biosci (Landmark Ed) 14: 4189-4198.
• Calamita, G., Ferri, D., Gena, P., Carreras, F. I., Liquori, G. E., Portincasa, P., Marinelli, R. A. and Svelto, M. (2008). Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis. Am J Physiol Gastrointest Liver Physiol 295(4): G682-690.
• Calamita, G., Moreno, M., Ferri, D., Silvestri, E., Roberti, P., Schiavo, L., Gena, P., Svelto, M. and Goglia, F. (2007). Triiodothyronine modulates the expression of aquaporin-8 in rat liver mitochondria. J Endocrinol 192(1): 111-120.
• Calamita, G., Gena, P., Meleleo, D., Ferri, D. and Svelto, M. (2006). Water permeability of rat liver mitochondria: A biophysical study. Biochim Biophys Acta 1758(8): 1018-1024.
• Calamita, G., Ferri, D., Gena, P., Liquori, G. E., Marinelli, R. A., Meyer, G., Portincasa, P. and Svelto, M. (2005). Water transport into bile and role in bile formation. Curr Drug Targets Immune Endocr Metabol Disord 5(2): 137-142.
• La Porta, C. A., Gena, P., Gritti, A., Fascio, U., Svelto, M. and Calamita, G. (2006). Adult murine CNS stem cells express aquaporin channels. Biol Cell 98(2): 89-94.
• Calamita, G., Ferri, D., Gena, P., Liquori, G. E., Cavalier, A., Thomas, D. and Svelto, M. (2005). The inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water. J Biol Chem 280(17): 17149-17153.
• Calamita G., Ferri D., Gena P., Liquori G. E., Marinelli R. A., Portincasa P., Svelto, M. (2005). Water transport into bile and role in bile formation. Current Drug Targets- Immune, Endocrine & Metabolic Disorders, 5: 137-142.
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