Agnieszka D’Antonio-Chronowska
  • Assistant Project Scientist, Department of Pediatrics, Department of Pediatrics, USA
Research fields
  • Stem cell
Personal information


Ph.D in Molecular Medicine, University of Milan and European Institute of Oncology (IEO), Milan, Italy, 2011;
M.Sc. in Biology, Jagiellonian University, Faculty of Biology and Earth Sciences, Cracow, Poland, 2005


Since 2006
• D'Antonio, M., Reyna, J., Jakubosky, D., Donovan, M. K., Bonder, M. J., Matsui, H., Stegle, O., Nariai, N., D'Antonio-Chronowska, A. and Frazer, K. A. (2019). Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease. Elife 8:e4847.
• D'Antonio-Chronowska, A., Donovan, M. K. R., Young Greenwald, W. W., Nguyen, J. P., Fujita, K., Hashem, S., Matsui, H., Soncin, F., Parast, M., Ward, M. C., Coulet, F., Smith, E. N., Adler, E., D'Antonio, M. and Frazer, K. A. (2019). Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories. Stem Cell Reports 13(5): 924-938.
• Greenwald, W. W., Li, H., Benaglio, P., Jakubosky, D., Matsui, H., Schmitt, A., Selvaraj, S., D'Antonio, M., D'Antonio-Chronowska, A., Smith, E. N. and Frazer, K. A. (2019). Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression. Nat Commun 10(1): 1054.
• Smith, E. N., D'Antonio-Chronowska, A., Greenwald, W. W., Borja, V., Aguiar, L. R., Pogue, R., Matsui, H., Benaglio, P., Borooah, S., D'Antonio, M., Ayyagari, R. and Frazer, K. A. (2019). Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci. Stem Cell Reports 12(6): 1342-1353.
• Barbagiovanni, G., Germain, P. L., Zech, M., Atashpaz, S., Lo Riso, P., D'Antonio-Chronowska, A., Tenderini, E., Caiazzo, M., Boesch, S., Jech, R., Haslinger, B., Broccoli, V., Stewart, A. F., Winkelmann, J. and Testa, G. (2018). KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes. Cell Rep 25(4): 988-1001.
• D'Antonio, M., Benaglio, P., Jakubosky, D., Greenwald, W. W., Matsui, H., Donovan, M. K. R., Li, H., Smith, E. N., D'Antonio-Chronowska, A. and Frazer, K. A. (2018). Insights into the Mutational Burden of Human Induced Pluripotent Stem Cells from an Integrative Multi-Omics Approach. Cell Rep 24(4): 883-894.
• DeBoever, C., Li, H., Jakubosky, D., Benaglio, P., Reyna, J., Olson, K. M., Huang, H., Biggs, W., Sandoval, E., D'Antonio, M., Jepsen, K., Matsui, H., Arias, A., Ren, B., Nariai, N., Smith, E. N., D'Antonio-Chronowska, A., Farley, E. K. and Frazer, K. A. (2017). Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. Cell Stem Cell 20(4): 533-546 e537.
• M, D. A., Weghorn, D., A, D. A.-C., Coulet, F., Olson, K. M., DeBoever, C., Drees, F., Arias, A., Alakus, H., Richardson, A. L., Schwab, R. B., Farley, E. K., Sunyaev, S. R. and Frazer, K. A. (2017). Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nat Commun 8(1): 436.
• Miotti, S., Gulino, A., Ferri, R., Parenza, M., Chronowska, A., Lecis, D., Sangaletti, S., Tagliabue, E., Tripodo, C. and Colombo, M. P. (2017). Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. FASEB J 31(12): 5356-5370.
• Panopoulos, A. D., D'Antonio, M., Benaglio, P., Williams, R., Hashem, S. I., Schuldt, B. M., DeBoever, C., Arias, A. D., Garcia, M., Nelson, B. C., Harismendy, O., Jakubosky, D. A., Donovan, M. K. R., Greenwald, W. W., Farnam, K., Cook, M., Borja, V., Miller, C. A., Grinstein, J. D., Drees, F., Okubo, J., Diffenderfer, K. E., Hishida, Y., Modesto, V., Dargitz, C. T., Feiring, R., Zhao, C., Aguirre, A., McGarry, T. J., Matsui, H., Li, H., Reyna, J., Rao, F., O'Connor, D. T., Yeo, G. W., Evans, S. M., Chi, N. C., Jepsen, K., Nariai, N., Muller, F. J., Goldstein, L. S. B., Izpisua Belmonte, J. C., Adler, E., Loring, J. F., Berggren, W. T., D'Antonio-Chronowska, A., Smith, E. N. and Frazer, K. A. (2017). iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports 8(4): 1086-1100.
• Panopoulos, A. D., Smith, E. N., Arias, A. D., Shepard, P. J., Hishida, Y., Modesto, V., Diffenderfer, K. E., Conner, C., Biggs, W., Sandoval, E., D'Antonio-Chronowska, A., Berggren, W. T., Izpisua Belmonte, J. C. and Frazer, K. A. (2017). Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics. Cell Stem Cell 20(4): 505-517 e506.
• Austenaa, L., Barozzi, I., Chronowska, A., Termanini, A., Ostuni, R., Prosperini, E., Stewart, A. F., Testa, G. and Natoli, G. (2012). The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity 36(4): 572-585.
• Mannan, A. U., Krawen, P., Sauter, S. M., Boehm, J., Chronowska, A., Paulus, W., Neesen, J. and Engel, W. (2006). ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Am J Hum Genet 79(2): 351-357.
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