Reviewer
Srajan Kapoor
  • Post-Doc, Department of Structural Biology, University at Buffalo
Research fields
  • Biochemistry, Biophysics, Microbiology, Molecular Biology, Structural Biology
Personal information

Education

PhD, CSIR-Institute of Microbial Technology, 2021

Lab information

The Vecchio Laboratory

Research focus

Structure, function and dynamics of membrane proteins.

Publications

https://scholar.google.com/citations?user=sx7iF-wAAAAJ&hl=en
Chinemerem P Ogbu, Alexandria M Mandriota, Xiangdong Liu, Mason de Las Alas, Srajan Kapoor, Jagrity Choudhury, Anthony A Kossiakoff, Michael E Duffey, Alex J Vecchio. Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule. bioRxiv. doi: https://doi.org/10.1101/2024.11.10.622873

Martin Pacesa, Lennart Nickel, Christian Schellhaas, Joseph Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana Alcaraz-Serna, Yehlin Cho, Kourosh H Ghamary, Laura Vinué, Brahm J Yachnin, Andrew M Wollacott, Stephen Buckley, Adrie H Westphal, Simon Lindhoud, Sandrine Georgeon, Casper A Goverde, Georgios N Hatzopoulos, Pierre Gönczy, Yannick D Muller, Gerald Schwank, Daan C Swarts, Alex J Vecchio, Bernard L Schneider, Sergey Ovchinnikov, Bruno E Correia. BindCraft: one-shot design of functional protein binders. bioRxiv. doi: https://doi.org/10.1101/2024.09.30.615802

Mahey N, Tambat R, Kalia R, Ingavale R, Kodesia A, Chandal N, Kapoor S, Verma DK, Thakur KG, Jachak S, Nandanwar H. Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential. PLoS Pathog. 2024 Apr 9;20(4):e1012121. doi: 10.1371/journal.ppat.1012121. PMID: 38593161; PMCID: PMC11003683.

Goverde CA, Pacesa M, Goldbach N, Dornfeld LJ, Balbi PEM, Georgeon S, Rosset S, Kapoor S, Choudhury J, Dauparas J, Schellhaas C, Kozlov S, Baker D, Ovchinnikov S, Vecchio AJ, Correia BE. Computational design of soluble functional analogues of integral membrane proteins. Nature. 2024 Jul;631(8020):449-458 doi: 10.1038/s41586-024-07601-y

Ogbu CP*; Kapoor S*; Vecchio AJ. Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin. Toxins 2023, 15, 637. (*Equal contribution) https://doi.org/10.3390/toxins15110637

Kapoor S*, Kodesia A*, Kalidas N, Ashish, Thakur KG. Structural characterization of Myxococcus xanthus MglC, a component of polarity control system, and its interactions with its paralog MglB. Journal of Biological Chemistry (2021). (*Equal contribution) https://doi.org/10.1016/j.jbc.2021.100308

Solanki V*, Kapoor S*, Thakur KG. Structural insights into the mechanism of Type IVa pilus extension and retraction ATPase motors. The FEBS Journal, Volume 285, Issue 18 (2018). (*Equal contribution) https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.14619

Kaur G, Kapoor S, Thakur KG. Bacillus subtilis HelD, an RNA polymerase interacting helicase, forms amyloid-like fibrils. Frontiers of Microbiology, Volume 9, (2019). https://www.frontiersin.org/articles/10.3389/fmicb.2018.01934/full

Kaur G, Kaundal S, Kapoor S, Grimes JM, Huiskonen JT, Thakur KG. Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils. Scientific Reports, Volume 8, Issue 1, (2018). https://www.nature.com/articles/s41598-018-28290-4

Kaur G, Kapoor S, Kaundal S, Dutta D, Thakur KG. Structure-guided designing and evaluation of peptides targeting bacterial transcription. Frontiers in Biotechnology and Bioengineering (2020). https://www.frontiersin.org/articles/10.3389/fbioe.2020.00797/full

Verma D, Kapoor S, Das S, Thakur KG. Potential inhibitors of SARS-CoV-2 Main Protease (Mpro) identified from the Library of FDA-approved drugs using molecular docking studies. Biomedicines (2022). https://doi.org/10.3390/biomedicines11010085
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