HS
Hisashi Shirakawa
  • Post-doctoral Researcher, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2005-2006,
    Assistant Professor, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2006-2014;
    Associate Professor, Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2014-2019
Research fields
  • Neuroscience
Personal information

Education

Ph.D., Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, 2005

Publications

Selected
• Andoh, C., Nishitani, N., Hashimoto, E., Nagai, Y., Takao, K., Miyakawa, T., Nakagawa, T., Mori, Y., Nagayasu, K., Shirakawa, H. and Kaneko, S. (2019). TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res 1704: 68-77.
• Kakae, M., Miyanohara, J., Morishima, M., Nagayasu, K., Mori, Y., Shirakawa, H. and Kaneko, S. (2019). Pathophysiological Role of TRPM2 in Age-Related Cognitive Impairment in Mice. Neuroscience 408: 204-213.
• Kakae, M., Tobori, S., Morishima, M., Nagayasu, K., Shirakawa, H. and Kaneko, S. (2019). Depletion of microglia ameliorates white matter injury and cognitive impairment in a mouse chronic cerebral hypoperfusion model. Biochem Biophys Res Commun 514(4): 1040-1044.
• Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., Hewinson, J., Shirakawa, H., Nakagawa, T., Hashimoto, H., Kasparov, S. and Kaneko, S. (2019). Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology 44(4): 721-732.
• Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., Hewinson, J., Shirakawa, H., Nakagawa, T., Hashimoto, H., Kasparov, S. and Kaneko, S. (2019). Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology 44(4): 721-732.
• Shirakawa, H. and Kaneko, S. (2018). Physiological and Pathophysiological Roles of Transient Receptor Potential Channels in Microglia-Related CNS Inflammatory Diseases. Biol Pharm Bull 41(8): 1152-1157.
• Miyanohara, J., Kakae, M., Nagayasu, K., Nakagawa, T., Mori, Y., Arai, K., Shirakawa, H. and Kaneko, S. (2018). TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion. J Neurosci 38(14): 3520-3533.
• Kaneko, S. (2018). TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion. J Neurosci 38(14): 3520-3533.
• Tsutsui, M., Hirase, R., Miyamura, S., Nagayasu, K., Nakagawa, T., Mori, Y., Shirakawa, H. and Kaneko, S. (2018). TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines. J Neurosci 38(39): 8484-8495.
• Temma, T., Yamazaki, M., Miyanohara, J., Shirakawa, H., Kondo, N., Koshino, K., Kaneko, S. and Iida, H. (2017). Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of (15)O-gas in mice with bilateral common carotid artery stenosis. J Cereb Blood Flow Metab 37(10): 3334-3343.
• Miyake, T., Nakamura, S., Zhao, M., So, K., Inoue, K., Numata, T., Takahashi, N., Shirakawa, H., Mori, Y., Nakagawa, T. and Kaneko, S. (2016). Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun 7: 12840.
• So, K., Tei, Y., Zhao, M., Miyake, T., Hiyama, H., Shirakawa, H., Imai, S., Mori, Y., Nakagawa, T., Matsubara, K. and Kaneko, S. (2016). Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. Sci Rep 6: 23261. Miyanohara, J., Kakae, M., Nagayasu, K., Nakagawa, T., Mori, Y., Arai, K., Shirakawa, H. and
• Miyake, T., Shirakawa, H., Nakagawa, T. and Kaneko, S. (2015). Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration. Glia 63(10): 1870-1882.
• Munakata, M., Shirakawa, H., Nagayasu, K., Miyanohara, J., Miyake, T., Nakagawa, T., Katsuki, H. and Kaneko, S. (2013). Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice. Stroke 44(7): 1981-1987.
• Konno, M., Shirakawa, H., Iida, S., Sakimoto, S., Matsutani, I., Miyake, T., Kageyama, K., Nakagawa, T., Shibasaki, K. and Kaneko, S. (2012). Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide. Glia 60(5): 761-770.
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