Jörg Peters University Medicine of Greifswald, 2003-2019
1 protocol

Bettina Kränzlin Medical Research Center, University of Heidelberg, Medical Faculty Mannheim, Mannheim
1 protocol

Euan Clark Zentrum für Medizinische Forschung, Universität Heidelberg, 2014-2019
1 protocol

Wiktoria Banczyk Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim
1 protocol

Sigrid Christa Hoffmann
  • Research scientist, University of Heidelberg
Research focus
  • Molecular biology
  • chronic kidney diseases, diabetic nephropathy, polycystic kidney disease, renin angiotensin System, transgenic rat models
  • 1 Author merit


PhD, Humboldt University, 1984

Lab information

Sigrid Hoffmann Lab


Since 2015
• Micakovic T, Papagiannarou S, Clark E, Kuzay Y, Abramovic K, Peters J, Sticht C, Volk N, Fleming T, Nawroth P, Hammes HP, Alenina N, Gröne HJ, Hoffmann SC. The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus. Kidney Int. 2018 Nov;94(5):937-950. doi: 10.1016/j.kint.2018.06.006. Epub 2018 Sep 4. PubMed PMID: 30190172.
• Kolibabka M, Acunman K, Riemann S, Huang H, Gretz N, Hoffmann S, Feng Y, Hammes HP. Endothelial Wnt-Pathway Activation Protects the Blood-Retinal-Barrier during Neurodegeneration-Induced Vasoregression. Thromb Haemost Res. 2018; 2(1): 1010.
• Yiming Zhou1,2, Philip Castonguay, Eriene Sidhom, Abbe Clark, Moran Dvela-Levitt, Sookyung Kim, Jonas Sieber, Nicolas Wieder, Jiyong, Jung, Svetlana Andreeva, Jana Reichardt, Frank Dubois, Sigrid Hoffmann, John Basgen, Mónica S. Montesinos, Astrid Weins, Eric S. Lander, Michael R. Garrett, Corey Hopkins, Anna Greka (2017) Progressive kidney disease is suppressed by a small molecule inhibitor of TRPC5., Science, Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. PMID: 29217578
• Zwolanek D1, Satué M1, Proell V1, Godoy JR1, Odörfer KI1, Flicker M1, Hoffmann SC2, Rülicke T1, Erben RG1 (2017) Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model. JCI Insight. Oct 19;2(20)
• Gauer, Stefan, Holzmann, Yvonne, Kranzlin, Bettina, Hoffmann, Sigrid C, Gretz, Norbert, Hauser, Ingeborg A, Hauser IA, Goppelt-Struebe, Margarete, Geiger, Helmut, Obermuller, Nicholas. (2017). CTGF Is Expressed During Cystic Remodeling in the PKD/Mhm (cy/+) Rat Model for Autosomal-Dominant Polycystic Kidney Disease (ADPKD). J Histochem Cytochem. Dec;65(12):743-755. doi: 10.1369/0022155417735513. Epub 2017 Oct 23.
• Sulaj A1, Kopf S2, Gröne E3, Gröne HJ3, Hoffmann S4, Schleicher E5, Häring HU6, Schwenger V7, Herzig S8, Fleming T9, Nawroth PP10, von Bauer R2. ALCAM a novel biomarker in patients with type 2 diabetes mellitus complicated with diabetic nephropathy. J Diabetes Complications. 2017 Jan 21. pii: S1056-8727(16)30641-9.
• Gauer S, Urbschat A, Gretz N, Hoffmann SC, Kränzlin B, Geiger H, Obermüller N. Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease. 2016. Int. J. Mol. Sci. 24;17(6). pii: E802. doi: 10.3390/ijms17060802.
• Wanka H, Lutze P, Staar D, Peters B, Hildebrandt J, Beck B, Bäumgen I, Albers A, Krieg T, Zimmermann K, Scodrok J, Schäfer S, Hoffmann S, Peters J, Anti-Necrotic and Cardioprotective Effects of a cytosolic renin Isoform Under Ischemia Related Conditions. J Mol Med. 2016 94:61-69
• S. Hoffmann. Neue Aspekte von Angiotensin II-Wirkungen in der diabetischen Nephropathie und Glomerulosklerose. Nieren- und Hochdruckkrankheiten, 2016, 45:S. 1-4
• Laure Delestré, Bakey Z, Prado C, Hoffmann S, Bihoreau MT, Lelongt B, Gauguier D. ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and is Associated with Vasopressin Signaling and Apoptosis in vivo in Mice. PLoS ONE, 2015: 10(9): 0136781.doi:10.1371/journal.pone.
• Zeineb Bakey, Marie-Thérèse Bihoreau, Rémi Piedagnel, Laure Delestré, Catherine Arnould, Joanna H Brown, Olivier Devuyst, Sigrid Hoffmann, Pierre Ronco, Dominique Gauguier, Brigitte Lelongt. Role of the SAM domain of ANKS6 and its interacting partners in cystic kidney disease. Kidney International, 2015 Jun 3. doi: 10.1038/ki.2015.122. [Epub ahead of print]
1 Protocol published
Isolation of Pure Mitochondria from Rat Kidneys and Western Blot of Mitochondrial Respiratory Chain Complexes
Cardiac, neuronal and renal tubular epithelial cells are the most metabolically active cells in the body. Their fate depends largely on their mitochondria as the primary energy generating system which participates in the control of apoptosis, cell ...
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