Giulia Romano
  • Post-Doc, International Centre for Genetic Engineering and Biotechnology
Research fields
  • Cell Biology, Molecular Biology, Neuroscience, Drosophila melanogaster model, Neurobiology
Personal information


Ph.D, University of Nova Gorica, SLO, 2015

Lab information

Andes Muro Lab

Research focus

Mouse molecular genetic, gene therapy, Gilbert syndrome

1. Feiguin,F., Godena,V.K., Romano,G., D’Ambrogio,A., Klima,R. and Baralle,F.E. (2009) Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior. FEBS Lett., 583, 1586–1592.
2. Godena,V.K., Romano,G., Romano,M., Appocher,C., Klima,R., Buratti,E., Baralle,F.E. and Feiguin,F. (2011) TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization. PLOS ONE, 6, e17808.
3. Romano,G., Klima,R., Buratti,E., Verstreken,P., Baralle,F.E. and Feiguin,F. (2014) Chronological requirements of TDP-43 function in synaptic organization and locomotive control. Neurobiol. Dis., 10.1016/j.nbd.2014.07.007.
4. Romano,M., Buratti,E., Romano,G., Klima,R., Del Bel Belluz,L., Stuani,C., Baralle,F. and Feiguin,F. (2014) Evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins functionally interact with human and Drosophila TAR DNA-binding protein 43 (TDP-43). J. Biol. Chem., 289, 7121–7130.
5. Romano,G., Appocher,C., Scorzeto,M., Klima,R., Baralle,F.E., Megighian,A. and Feiguin,F. (2015) Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms. Hum. Mol. Genet., 24, 6134–6145.
6. Cragnaz,L., Klima,R., De Conti,L., Romano,G., Feiguin,F., Buratti,E., Baralle,M. and Baralle,F.E. (2015) An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model. Neuroscience, 311, 415–421.
7. Langellotti,S., Romano,V., Romano,G., Klima,R., Feiguin,F., Cragnaz,L., Romano,M. and Baralle,F.E. (2016) A novel fly model of TDP-43 proteinopathies: N-terminus sequences combined with the Q/N domain induce protein functional loss and locomotion defects. Dis. Model. Mech., 10.1242/dmm.023382.
8. Langellotti,S., Romano,G., Feiguin,F., Baralle,F.E. and Romano,M. (2018) RhoGAPp190: A potential player in tbph-mediated neurodegeneration in Drosophila. PloS One, 13, e0195845.
9. Lo Piccolo,L., Bonaccorso,R., Attardi,A., Li Greci,L., Romano,G., Sollazzo,M., Giurato,G., Ingrassia,A.M.R., Feiguin,F., Corona,D.F.V., et al. (2018) Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43. Int. J. Mol. Sci., 19.
10. Romano,G., Holodkov,N., Klima,R., Grilli,F., Guarnaccia,C., Nizzardo,M., Rizzo,F., Garcia,R. and Feiguin,F. (2018) Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses. Sci. Rep., 8, 1809.
11. Donadon,I., Bussani,E., Riccardi,F., Licastro,D., Romano,G., Pianigiani,G., Pinotti,M., Konstantinova,P., Evers,M., Lin,S., et al. (2019) Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA. Nucleic Acids Res., 47, 7618–7632.
12. Strah,N., Romano,G., Introna,C., Klima,R., Marzullo,M., Ciapponi,L., Megighian,A., Nizzardo,M. and Feiguin,F. (2020) TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles. BMC Biol., 18, 34.
13. Romano,G., Klima,R. and Feiguin,F. (2020) TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity. BMC Biol., 18, 82.
14. Klima,R., Romano,G., Gbadamosi,M., Megighian,A. and Feiguin,F. (2021) Immuno-electrophysiology on Neuromuscular Junctions of Drosophila Third Instar Larva. Bio-Protoc., 11, e3913–e3913.
15. Romano,G., Holodkov,N., Klima,R. and Feiguin,F. (2021) TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS. Sci. Rep., 11, 1–8.
16. Romano,G., Klima,R. and Feiguin,F. (2021) Immunoprecipitation for Protein-Protein Interactions and for RNA Enrichment in Drosophila melanogaster. Bio-Protoc., 11, e4250–e4250.
17. Romano,G., Riccardi,F., Bussani,E., Vodret,S., Licastro,D., Ragone,I., Ronzitti,G., Morini,E., Slaugenhaupt,S.A. and Pagani,F. (2022) Rescue of a familial dysautonomia mouse model by AAV9-Exon-specific U1 snRNA. Am. J. Hum. Genet., 10.1016/j.ajhg.2022.07.004.
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