Gal Haimovich Molecular Genetics, Weizmann Institute of Science, Israel
103 protocols

Philipp Wörsdörfer University of Würzburg
5 protocols

Xi Feng University of California, San Francisco
35 protocols

Chaitali Basole
  • Research scientist, Precision Biosciences
Research focus
  • Immunology
  • 1. Phosphodiesterases
    2. Autoimmunity
    3. Cell motility
    4. Inflammation
    5. Leukocyte adhesion
    6. Signal transduction pathways (cAMP, cGMP, MAPK etc.)
    7. Protein-protein interactions
    8. Signalosomes/signaling complexes.
    9. Cancer Immunotherapy
    10. CAR T cells


PhD Biomedical Sciences, UConn Health, CT, USA, 2017

1] Basole C, Nguyen R, Lamothe K, Vang AG, Clark RB, Baillie G, Epstein PM, Brocke S. PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Signal. 2017 Aug 26. [PMID: 28851628]
2] Vang AG*, Basole C*, Dong H, Nguyen R, Housley W, Guernsey L, Thrall R, Epstein PM, Clark RB, Brocke S. Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation. Front. Pharmacol. 2016 Aug 23. [PMID: 27601994] (* Co-first authors)
3] Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013 Dec 15. [PMID: 24007532]
4] Cervantes JL, Weinerman B, Basole C, Salazar JC. TLR8: the forgotten relative revindicated. Cell Mol Immunol. 2012 Nov. [PMID: 23085951]
3 Protocols reviewed
Single Cell Migration Assay Using Human Breast Cancer MDA-MB-231 Cell Line
Authors:  David M. Gau and Partha Roy, date: 04/20/2020, view: 3794, Q&A: 0
Cell migration is a fundamental cellular process that plays a crucial role in many physioglogical and pathological processes such as wound healing or cancer metastasis. Many assays have been developed to examine cell migration, such as the wound ...
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Single-cell qPCR Assay with Massively Parallel Microfluidic System
Authors:  Marta Prieto-Vila, Takahiro Ochiya and Yusuke Yamamoto, date: 03/20/2020, view: 2664, Q&A: 0
The single-cell transcriptome is the set of messenger RNA molecules expressed in one cell. It is extremely variable and changes according to external, physical and biochemical conditions. Due to sensitivity shortages, most of genetic studies use ...
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