Education
PhD Biomedical Sciences, UConn Health, CT, USA, 2017
Research focus
1. Phosphodiesterases
2. Autoimmunity
3. Cell motility
4. Inflammation
5. Leukocyte adhesion
6. Signal transduction pathways (cAMP, cGMP, MAPK etc.)
7. Protein-protein interactions
8. Signalosomes/signaling complexes.
9. Cancer Immunotherapy
10. CAR T cells
Publications
https://www.ncbi.nlm.nih.gov/pubmed/?term=Basole+C1] Basole C, Nguyen R, Lamothe K, Vang AG, Clark RB, Baillie G, Epstein PM, Brocke S. PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Signal. 2017 Aug 26. [PMID: 28851628]
2] Vang AG*, Basole C*, Dong H, Nguyen R, Housley W, Guernsey L, Thrall R, Epstein PM, Clark RB, Brocke S. Differential expression and function of PDE8 and PDE4 in effector T cells: Implications for PDE8 as a drug target in inflammation. Front. Pharmacol. 2016 Aug 23. [PMID: 27601994] (* Co-first authors)
3] Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem J. 2013 Dec 15. [PMID: 24007532]
4] Cervantes JL, Weinerman B, Basole C, Salazar JC. TLR8: the forgotten relative revindicated. Cell Mol Immunol. 2012 Nov. [PMID: 23085951]