Jens Gruber
  • Medical RNA Biology, German Primate Center, Germany, Germany,
Research focus
  • Molecular biology
Personal information


Ph.D. (Molecular Biology), University of Göttingen, International Max-Planck Research School, Germany, 2005

Current position

Group Leader, Medical RNA Biology, German Primate Center, Germany


  1. Schiller, L. T., Lemus-Diaz, N., Rinaldi Ferreira, R., Böker, K. O. and Gruber, J. (2018). Enhanced Production of Exosome-Associated AAV by Overexpression of the Tetraspanin CD9. Molecular Therapy. Methods & Clinical Development 9: 278-287. 

  2. Hoffmann, D. B., Gruber, J., Böker, K. O., Deppe, D., Sehmisch, S., Schilling, A. F., Lemus-Diaz, N., Komrakova, M. and Schneider, S. (2018). Effects of RANKL Knockdown by Virus-like Particle-Mediated RNAi in a Rat Model of Osteoporosis. Molecular Therapy. Nucleic Acids 12: 443-452. 

  3. Boker, K. O., Lemus-Diaz, N., Rinaldi Ferreira, R., Schiller, L., Schneider, S. and Gruber, J. (2018). The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion. Mol Ther 26(2): 634-647. 

  4. Zmora, P., Molau-Blazejewska, P., Bertram, S., Walendy-Gnirss, K., Nehlmeier, I., Hartleib, A., Moldenhauer, A. S., Konzok, S., Dehmel, S., Sewald, K., Brinkmann, C., Curths, C., Knauf, S., Gruber, J., Matz-Rensing, K., Dahlmann, F., Braun, A. and Pohlmann, S. (2017). Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin. PLoS One 12(5): e0176597. 

  5. Pöhlmann, S., Krüger, A., Hafezi, W., Schneider, S., Gruber, J., Winkler, M., and Kaul, A. (2017). Detection systems for antibody responses against herpes B virus. Primate Biol(4): 9-16.

  6. Lemus-Diaz, N., Boker, K. O., Rodriguez-Polo, I., Mitter, M., Preis, J., Arlt, M. and Gruber, J. (2017). Dissecting miRNA gene repression on single cell level with an advanced fluorescent reporter system. Sci Rep 7: 45197. 

  7. Jo, P., Azizian, A., Salendo, J., Kramer, F., Bernhardt, M., Wolff, H. A., Gruber, J., Grade, M., Beissbarth, T., Ghadimi, B. M. and Gaedcke, J. (2017). Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy. Int J Mol Sci 18(6). 

  8. Hoffmann, D. B., Boker, K. O., Schneider, S., Eckermann-Felkl, E., Schuder, A., Komrakova, M., Sehmisch, S. and Gruber, J. (2016). In Vivo siRNA Delivery Using JC Virus-like Particles Decreases the Expression of RANKL in Rats. Mol Ther Nucleic Acids 5: e298. 

  9. Azizian, A., Gruber, J., Ghadimi, B. M. and Gaedcke, J. (2016). MicroRNA in rectal cancer. World J Gastrointest Oncol 8(5): 416-426. 

  10. Gruber, J., See Too, W. C., Wong, M. T., Lavie, A., McSorley, T. and Konrad, M. (2012). Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy. Febs j 279(11): 1915-1928. 

  11. Brameier, M., Herwig, A., Reinhardt, R., Walter, L. and Gruber, J. (2011). Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs. Nucleic Acids Res 39(2): 675-686. 

  12. Liu, Y. P., Gruber, J., Haasnoot, J., Konstantinova, P. and Berkhout, B. (2009). RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences. Nucleic Acids Res 37(18): 6194-6204. 

  13. Hossbach, M., Gruber, J., Osborn, M., Weber, K. and Tuschl, T. (2006). Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA Biol 3(2): 82-89. 

  14. Gruber, J., Manninga, H., Tuschl, T., Osborn, M. and Weber, K. (2005). Specific RNAi mediated gene knockdown in zebrafish cell lines. RNA Biol 2(3): 101-105. 

  15. Gruber, J. (2005). Functional gene analysis in cultured vertebrate cells using siRNA mediated gene silencing. Dissertation. University of Gottingen.

  16. Gruber, J., Lampe, T., Osborn, M. and Weber, K. (2005). RNAi of FACE1 protease results in growth inhibition of human cells expressing lamin A: implications for Hutchinson-Gilford progeria syndrome. J Cell Sci 118(Pt 4): 689-696. 

  17. Gruber, J., Boese, G., Tuschl, T., Osborn, M. and Weber, K. (2004). RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells. Biotechniques 37(1): 96-102. 

  18. Gruber, J., Harborth, J., Schnabel, J., Weber, K. and Hatzfeld, M. (2002). The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J Cell Sci 115(Pt 21): 4053-4059.

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