David DeSantis
  • Department of Nutrition, Case Western Reserve University, USA, USA,
Research focus
  • Immunology
Personal information


PhD, Case Western Reserve University, United States of America, 2015

Current position

Manager, Educational Affairs, Cardiometabolic & Endocrinology Franchise, Quest Diagnostics, United States of America, 2015-2018


  1. Gao, Y., Erokwu, B. O., DeSantis, D. A., Croniger, C. M., Schur, R. M., Lu, L., Mariappuram, J., Dell, K. M. and Flask, C. A. (2016). Initial evaluation of hepatic T1 relaxation time as an imaging marker of liver disease associated with autosomal recessive polycystic kidney disease (ARPKD). NMR Biomed 29(1): 84-89. 

  2. DeSantis, D. A., Ko, C. W., Wang, L., Lee, P. and Croniger, C. M. (2015). Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy. Mediators Inflamm 2015: 909827. 

  3. De, S., Zhou, H., DeSantis, D., Croniger, C. M., Li, X. and Stark, G. R. (2015). Erlotinib protects against LPS-induced endotoxicity because TLR4 needs EGFR to signal. Proc Natl Acad Sci U S A 112(31): 9680-9685. 

  4. DeSantis, D. A., Lee, P., Doerner, S. K., Ko, C. W., Kawasoe, J. H., Hill-Baskin, A. E., Ernest, S. R., Bhargava, P., Hur, K. Y., Cresci, G. A., Pritchard, M. T., Lee, C. H., Nagy, L. E., Nadeau, J. H. and Croniger, C. M. (2013). Genetic resistance to liver fibrosis on A/J mouse chromosome 17. Alcohol Clin Exp Res 37(10): 1668-1679. 

  5. DeSantis, D. A., Ko, C. W., Liu, Y., Liu, X., Hise, A. G., Nunez, G. and Croniger, C. M. (2013). Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice. Mediators Inflamm 2013: 751374. 

  6. Berry, D. C., Jacobs, H., Marwarha, G., Gely-Pernot, A., O'Byrne, S. M., DeSantis, D., Klopfenstein, M., Feret, B., Dennefeld, C., Blaner, W. S., Croniger, C. M., Mark, M., Noy, N. and Ghyselinck, N. B. (2013). The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem 288(34): 24528-24539. 

  7. Berry, D. C., DeSantis, D., Soltanian, H., Croniger, C. M. and Noy, N. (2012). Retinoic acid upregulates preadipocyte genes to block adipogenesis and suppress diet-induced obesity. Diabetes 61(5): 1112-1121. 

  8. Hsieh CW, D. D., Croniger CM ( 2011). Role of Triglyceride/Fatty Acid cycle in development of type2 diabetes. In Endocrinology and Metabolism.  Croniger, Cleveland, Case Western Reserve University.

  9. Millward, C. A., Desantis, D., Hsieh, C. W., Heaney, J. D., Pisano, S., Olswang, Y., Reshef, L., Beidelschies, M., Puchowicz, M. and Croniger, C. M. (2010). Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice. J Lipid Res 51(6): 1452-1463. 

  10. Hsieh, C. W., Millward, C. A., DeSantis, D., Pisano, S., Machova, J., Perales, J. C. and Croniger, C. M. (2009). Reduced milk triglycerides in mice lacking phosphoenolpyruvate carboxykinase in mammary gland adipocytes and white adipose tissue contribute to the development of insulin resistance in pups. J Nutr 139(12): 2257-2265. 

  11. Hill-Baskin, A. E., Markiewski, M. M., Buchner, D. A., Shao, H., DeSantis, D., Hsiao, G., Subramaniam, S., Berger, N. A., Croniger, C., Lambris, J. D. and Nadeau, J. H. (2009). Diet-induced hepatocellular carcinoma in genetically predisposed mice. Hum Mol Genet 18(16): 2975-2988. 

  12. Berryman, D. E., Palmer, A. J., Gosney, E. S., Swaminathan, S., DeSantis, D. and Kopchick, J. J. (2007). Discovery and uses of pegvisomant: a growth hormone antagonist. Endokrynol Pol 58(4): 322-329.

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