Daniel J.-F. Chinnapen
  • Faculty, Gastroenterology, Boston Childrens Hospital, United States, United States,
Research focus
  • Cell biology
Personal information


PhD, Simon Fraser University, Canada, 2005

Current position

Assistant Professor, Pediatrics, Harvard Medical School, United States
Staff Scientist, Pediatrics, Boston Children's Hospital, United States


  1. Garcia-Castillo, M. D., Chinnapen, D. J., Te Welscher, Y. M., Gonzalez, R. J., Softic, S., Pacheco, M., Mrsny, R. J., Kahn, C. R., von Andrian, U. H., Lau, J., Pentelute, B. L. and Lencer, W. I. (2018). Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife 7. 
  2. Cho, J. A. and Chinnapen, D. J. F. (2018). Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease. J Microbiol 56(3): 183-188. 
  3. Garcia-Castillo, M. D., Chinnapen, D. J. and Lencer, W. I. (2017). Membrane Transport across Polarized Epithelia. Cold Spring Harb Perspect Biol 9(9). 
  4. Raghunathan, K., Wong, T. H., Chinnapen, D. J., Lencer, W. I., Jobling, M. G. and Kenworthy, A. K. (2016). Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains. Biophys J 111(12): 2547-2550. 
  5. Day, C. A., Baetz, N. W., Copeland, C. A., Kraft, L. J., Han, B., Tiwari, A., Drake, K. R., De Luca, H., Chinnapen, D. J., Davidson, M. W., Holmes, R. K., Jobling, M. G., Schroer, T. A., Lencer, W. I. and Kenworthy, A. K. (2015). Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis. Traffic 16(6): 572-590.
  6. te Welscher, Y. M., Chinnapen, D. J., Kaoutzani, L., Mrsny, R. J. and Lencer, W. I. (2014). Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. J Control Release 175: 72-78.
  7. Saslowsky, D. E., te Welscher, Y. M., Chinnapen, D. J., Wagner, J. S., Wan, J., Kern, E. and Lencer, W. I. (2013). Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. J Biol Chem 288(36): 25804-25809. 
  8. Chinnapen, D. J., Hsieh, W. T., te Welscher, Y. M., Saslowsky, D. E., Kaoutzani, L., Brandsma, E., D'Auria, L., Park, H., Wagner, J. S., Drake, K. R., Kang, M., Benjamin, T., Ullman, M. D., Costello, C. E., Kenworthy, A. K., Baumgart, T., Massol, R. H. and Lencer, W. I. (2012). Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell 23(3): 573-586. 
  9. Cho, J. A., Chinnapen, D. J., Aamar, E., te Welscher, Y. M., Lencer, W. I. and Massol, R. (2012). Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front Cell Infect Microbiol 2: 51. 
  10. Janz, J. M., Ren, Y., Looby, R., Kazmi, M. A., Sachdev, P., Grunbeck, A., Haggis, L., Chinnapen, D., Lin, A. Y., Seibert, C., McMurry, T., Carlson, K. E., Muir, T. W., Hunt, S., 3rd and Sakmar, T. P. (2011). Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. J Am Chem Soc 133(40): 15878-15881. 
  11. Fortin, J. P., Chinnapen, D., Beinborn, M., Lencer, W. and Kopin, A. S. (2011). Discovery of dual-action membrane-anchored modulators of incretin receptors. PLoS One 6(9): e24693. 
  12. Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W. I., Taguchi, T. and Arai, H. (2011). Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc Natl Acad Sci U S A 108(38): 15846-15851. 
  13. Saslowsky, D. E., Cho, J. A., Chinnapen, H., Massol, R. H., Chinnapen, D. J., Wagner, J. S., De Luca, H. E., Kam, W., Paw, B. H. and Lencer, W. I. (2010). Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest 120(12): 4399-4409. 
  14. Wernick, N. L., Chinnapen, D. J., Cho, J. A. and Lencer, W. I. (2010). Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel) 2(3): 310-325. 
  15. Thorne, R. E., Chinnapen, D. J., Sekhon, G. S. and Sen, D. (2009). A deoxyribozyme, Sero1C, uses light and serotonin to repair diverse pyrimidine dimers in DNA. J Mol Biol 388(1): 21-29. 
  16. Chinnapen, D. J., Chinnapen, H., Saslowsky, D. and Lencer, W. I. (2007). Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett 266(2): 129-137. 
  17. Chinnapen, D. J. and Sen, D. (2007). Towards elucidation of the mechanism of UV1C, a deoxyribozyme with photolyase activity. J Mol Biol 365(5): 1326-1336. 
  18. Howarth, M., Chinnapen, D. J., Gerrow, K., Dorrestein, P. C., Grandy, M. R., Kelleher, N. L., El-Husseini, A. and Ting, A. Y. (2006). A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods 3(4): 267-273. 
  19. Lee, H. W., Chinnapen, D. J. F. and Sen, D. (2004). Structure-function investigation of a deoxyribozyme with dual chelatase and peroxidase activities. Pure and Applied Chemistry 76: 1537.
  20. Chinnapen, D. J. and Sen, D. (2004). A deoxyribozyme that harnesses light to repair thymine dimers in DNA. Proc Natl Acad Sci U S A 101(1): 65-69. 
  21. Sen, D. and Chinnapen, D. J. (2003). Deoxyribozymes that catalyze photochemistry: cofactor-dependent and -independent photorepair of thymine dimers. Nucleic Acids Res Suppl (3): 217-218. 
  22. Chinnapen, D. J. and Sen, D. (2002). Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex. Biochemistry 41(16): 5202-5212. 
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.