Jan Strnadel
  • Department of Pathology, University of California, USA, USA,
Research focus
  • Cancer biology
Personal information


PhD, Laboratory of Tumor Biology, Institute of Animal Physiology and Genetics, vvi., Libechov, Czech republic and Czech University of Life Science in Prague, Czech republic, Czech Republic, 2007

Current position

Research Scientist, Department of Molecular Medicine, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia


  1. Noriega-Guerra, H., Cruz, M. C., Ribeiro, P. R. L., Strnadel, J., Wang, H., Klemke, R. L., Jaeger, R. G. and Freitas, V. M. (2018). ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res 363(2): 271-282.
  2. Strnadel, J., Choi, S., Fujimura, K., Wang, H., Zhang, W., Wyse, M., Wright, T., Gross, E., Peinado, C., Park, H. W., Bui, J., Kelber, J., Bouvet, M., Guan, K. L. and Klemke, R. L. (2017). eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res 77(8): 1997-2007.
  3. Acharya, M. M., Martirosian, V., Christie, L. A., Riparip, L., Strnadel, J., Parihar, V. K. and Limoli, C. L. (2015). Defining the optimal window for cranial transplantation of human induced pluripotent stem cell-derived cells to ameliorate radiation-induced cognitive impairment. Stem Cells Transl Med 4(1): 74-83.
  4. Planska, D., Burocziova, M., Strnadel, J. and Horak, V. (2015). Immunohistochemical Analysis of Collagen IV and Laminin Expression in Spontaneous Melanoma Regression in the Melanoma-Bearing Libechov Minipig. Acta Histochem Cytochem 48(1): 15-26.
  5. Juhasova, J., Juhas, S., Hruska-Plochan, M., Dolezalova, D., Holubova, M., Strnadel, J., Marsala, S., Motlik, J. and Marsala, M. (2015). Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies. Cell Mol Neurobiol 35(1): 57-70.
  6. Pasillas, M. P., Shields, S., Reilly, R., Strnadel, J., Behl, C., Park, R., Yates, J. R., 3rd, Klemke, R., Gonias, S. L. and Coppinger, J. A. (2015). Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Mol Cell Proteomics 14(1): 1-14.
  7. Fujimura, K., Wright, T., Strnadel, J., Kaushal, S., Metildi, C., Lowy, A. M., Bouvet, M., Kelber, J. A. and Klemke, R. L. (2014). A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res 74(22): 6671-6681.
  8. Dolezalova, D., Hruska-Plochan, M., Bjarkam, C. R., Sorensen, J. C., Cunningham, M., Weingarten, D., Ciacci, J. D., Juhas, S., Juhasova, J., Motlik, J., Hefferan, M. P., Hazel, T., Johe, K., Carromeu, C., Muotri, A., Bui, J., Strnadel, J. and Marsala, M. (2014). Pig models of neurodegenerative disorders: Utilization in cell replacement-based preclinical safety and efficacy studies. J Comp Neurol 522(12): 2784-2801.
  9. Stoletov, K., Strnadel, J., Zardouzian, E., Momiyama, M., Park, F. D., Kelber, J. A., Pizzo, D. P., Hoffman, R., VandenBerg, S. R. and Klemke, R. L. (2013). Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci 126(Pt 4): 904-913.
  10. Choi, S., Kelber, J., Jiang, X., Strnadel, J., Fujimura, K., Pasillas, M., Coppinger, J. and Klemke, R. (2014). Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Anal Biochem 446: 102-107.
  11. Lan, M. L., Acharya, M. M., Tran, K. K., Bahari-Kashani, J., Patel, N. H., Strnadel, J., Giedzinski, E. and Limoli, C. L. (2012). Characterizing the radioresponse of pluripotent and multipotent human stem cells. PLoS One 7(12): e50048.
  12. Kakinohana, O., Hefferan, M. P., Miyanohara, A., Nejime, T., Marsala, S., Juhas, S., Juhasova, J., Motlik, J., Kucharova, K., Strnadel, J., Platoshyn, O., Lazar, P., Galik, J., Vinay, L. and Marsala, M. (2012). Combinational spinal GAD65 gene delivery and systemic GABA-mimetic treatment for modulation of spasticity. PLoS One 7(1): e30561.
  13. Juhasova, J., Juhas, S., Klima, J., Strnadel, J., Holubova, M. and Motlik, J. (2011). Osteogenic differentiation of miniature pig mesenchymal stem cells in 2D and 3D environment. Physiol Res 60(3): 559-571.
  14. Krizkova, S., Fabrik, I., Adam, V., Kukacka, J., Prusa, R., Trnkova, L.,  Strnadel, J., Horak, V., Kizek, R.(2009). Effects of Reduced Glutathione, Surface Active Agents, and Ionic Strength on the Detection of Metallothioneins by Using of Brdicka ReactionElectroanalysis 2009;21: 640 – 644. 
  15. Krizkova, S., Fabrik, I., Adam, V., Kukacka, J., Prusa, R., Chavis, G. J., Trnkova, L., Strnadel, J., Horak, V. and Kizek, R. (2008). Utilizing of Adsorptive Transfer Stripping Technique Brdicka Reaction for Determination of Metallothioneins Level in Melanoma Cells, Blood Serum and Tissues. Sensors (Basel) 8(5): 3106-3122.
  16. Usvald, D., Hlucilova, J., Strnadel, J. Prochazka R, Motlik, J., Marsala, M. (2008). Permanent jugular catheterization in miniature pig: treatment, clinical and pathological observations. Veterinarni medicina 53: 365-372.
  17. Holubova, M.,  Strnadel, J., Usvald, D., Klaudy, J., Planska, D., Vannucci, L., Vana, P., Reisnerova, H., Jilek, F., Horak, V. (2008). Therapeutic versus pathological fusion of cancer cells with immune cells – tumor vaccines versus tumor hybrids. Bioprospect 3: 39-41. 
  18. Strnadel, J., Kverka, M., Reisnerova, H., Hlucilova, J., Usvald, D., Planská, D., Vana, P., Jilek, F., Vannucci, L., Horak, V. (2008). Protein chips in Cytokine Expression Study on Tumour Model: Optimalization of Sample Preparation. Chem. Listy 102: 269-273. 
  19. Strnadel, J., Kverka, M., Horak, V., Vannucci, L., Usvald, D., Hlucilova, J., Planska, D., Vana, P., Reisnerova, H. and Jilek, F. (2007). Multiplex analysis of cytokines involved in tumour growth and spontaneous regression in a rat sarcoma model. Folia Biol (Praha) 53(6): 216-219.
  20. Strnadel, J., Reisnerova, H., Hlucilova, J., Usvald, D., Horak, V. (2006). Cytokines in characterization of anti-tumor immune response using MeLiM melanoma model. Bioprospekt 3: 19-21.
  21. Moravkova, A., Malek, O., Pokorna, E., Strnadel, J., Hradecky, J. and Horak, V. (2005). Immune characterization of the Lewis rats inoculated with K2 sarcoma cell line and newly derived R5-28 malignant cells. Folia Biol (Praha) 51(6): 159-165.

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