Sara R Jones
  • Department of Physiology and Pharmacology, Wake Forest School of Medicine, United States, United States,
Research focus
  • Neuroscience
Personal information


PhD, University of North Carolina at Chapel Hill, USA, 1994

Current position

Professor, Department of Physiology and Pharmacology, Wake Forest School of Medicine, USA

Publications (Since 2015)

  1. McGuiera, N. S., Rinkera, J. A., Cannady, R., Fulmera, D. F., Jones, S. R., Hoffman, M. and Mulholland, P. J. (2018) Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in rodents. (Unpublished)
  2. Siciliano, C. A., Saha, K., Calipari, E. S., Fordahl, S. C., Chen, R., Khoshbouei, H. and Jones, S. R. (2018). Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. J Neurosci 38(2): 484-497. 

  3. Siciliano, C. A., Locke, J. L., Mathews, T. A., Lopez, M. F., Becker, H. C. and Jones, S. R. (2017). Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. Alcohol 58: 25-32. 

  4. Shaw, J. K., Ferris, M. J., Locke, J. L., Brodnik, Z. D., Jones, S. R. and Espana, R. A. (2017). Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. Addict Biol 22(6): 1695-1705. 

  5. Fordahl, S. C. and Jones, S. R. (2017). High-Fat-Diet-Induced Deficits in Dopamine Terminal Function Are Reversed by Restoring Insulin Signaling. ACS Chem Neurosci 8(2): 290-299. 

  6. Siciliano, C. A., McIntosh, J. M., Jones, S. R. and Ferris, M. J. (2017). alpha6beta2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty. Neuropharmacology 126: 281-291. 

  7. Siciliano, C. A. and Jones, S. R. (2017). Cocaine Potency at the Dopamine Transporter Tracks Discrete Motivational States During Cocaine Self-Administration. Neuropsychopharmacology 42(9): 1893-1904. 

  8. Melchior, J. R. and Jones, S. R. (2017). Chronic ethanol exposure increases inhibition of optically targeted phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Mol Cell Neurosci 85: 93-104. 

  9. Brodnik, Z. D., Ferris, M. J., Jones, S. R. and Espana, R. A. (2017). Reinforcing Doses of Intravenous Cocaine Produce Only Modest Dopamine Uptake Inhibition. ACS Chem Neurosci 8(2): 281-289. 

  10. Yorgason, J. T., Calipari, E. S., Ferris, M. J., Karkhanis, A. N., Fordahl, S. C., Weiner, J. L. and Jones, S. R. (2016). Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum. Neuropharmacology 101: 471-479. 

  11. Karkhanis, A. N., Rose, J. H., Weiner, J. L. and Jones, S. R. (2016). Early-Life Social Isolation Stress Increases Kappa Opioid Receptor Responsiveness and Downregulates the Dopamine System. Neuropsychopharmacology 41(9): 2263-2274. 

  12. Silverstein-Metzler, M. G., Shively, C. A., Clarkson, T. B., Appt, S. E., Carr, J. J., Kritchevsky, S. B., Jones, S. R. and Register, T. C. (2016). Sertraline inhibits increases in body fat and carbohydrate dysregulation in adult female cynomolgus monkeys. Psychoneuroendocrinology 68: 29-38. 

  13. Siciliano, C. A., Calipari, E. S., Yorgason, J. T., Lovinger, D. M., Mateo, Y., Jimenez, V. A., Helms, C. M., Grant, K. A. and Jones, S. R. (2016). Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology (Berl) 233(8): 1435-1443. 

  14. Brust, T. F., Morgenweck, J., Kim, S. A., Rose, J. H., Locke, J. L., Schmid, C. L., Zhou, L., Stahl, E. L., Cameron, M. D., Scarry, S. M., Aube, J., Jones, S. R., Martin, T. J. and Bohn, L. M. (2016). Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal 9(456): ra117. 

  15. Salvatore, M. F., Calipari, E. S. and Jones, S. R. (2016). Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS Chem Neurosci 7(7): 941-951. 

  16. Siciliano, C. A., Fordahl, S. C. and Jones, S. R. (2016). Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to Cocaine. J Neurosci 36(30): 7807-7816. 

  17. Cervera-Juanes, R., Wilhem, L. J., Park, B., Lee, R., Locke, J., Helms, C., Gonzales, S., Wand, G., Jones, S. R., Grant, K. A. and Ferguson, B. (2016). MAOA expression predicts vulnerability for alcohol use. Mol Psychiatry 21(4): 472-479. 

  18. Butler, T. R., Karkhanis, A. N., Jones, S. R. and Weiner, J. L. (2016). Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders. Alcohol Clin Exp Res 40(6): 1202-1214. 

  19. Karkhanis, A. N., Beveridge, T. J., Blough, B. E., Jones, S. R. and Ferris, M. J. (2016). The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Drug Alcohol Depend 166: 51-60. 

  20. Siciliano, C. A., Calipari, E. S., Yorgason, J. T., Mateo, Y., Helms, C. M., Lovinger, D. M., Grant, K. A. and Jones, S. R. (2016). Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend 158: 159-163. 

  21. Rose, J. H., Karkhanis, A. N., Steiniger-Brach, B. and Jones, S. R. (2016). Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure. Int J Mol Sci 17(8). 

  22. McGinnis, M. M., Siciliano, C. A. and Jones, S. R. (2016). Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter. J Neurochem 138(6): 821-829. 

  23. Fordahl, S. C., Locke, J. L. and Jones, S. R. (2016). High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. Neuropharmacology 109: 170-182. 

  24. Karkhanis, A. N., Huggins, K. N., Rose, J. H. and Jones, S. R. (2016). Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: Role of kappa opioid receptors. Neuropharmacology 110(Pt A): 190-197. 

  25. Calipari, E. S., Ferris, M. J., Siciliano, C. A. and Jones, S. R. (2015). Differential influence of dopamine transport rate on the potencies of cocaine, amphetamine, and methylphenidate. ACS Chem Neurosci 6(1): 155-162. 

  26. Siciliano, C. A., Calipari, E. S., Cuzon Carlson, V. C., Helms, C. M., Lovinger, D. M., Grant, K. A. and Jones, S. R. (2015). Voluntary ethanol intake predicts kappa-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques. J Neurosci 35(15): 5959-5968. 

  27. Karkhanis, A. N., Rose, J. H., Huggins, K. N., Konstantopoulos, J. K. and Jones, S. R. (2015). Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens. Drug Alcohol Depend 150: 24-30. 

  28. Siciliano, C. A., Ferris, M. J. and Jones, S. R. (2015). Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. Eur J Neurosci 42(4): 2091-2096. 

  29. Richardson, J. R., Taylor, M. M., Shalat, S. L., Guillot, T. S., 3rd, Caudle, W. M., Hossain, M. M., Mathews, T. A., Jones, S. R., Cory-Slechta, D. A. and Miller, G. W. (2015). Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J 29(5): 1960-1972. 

  30. Yorgason, J. T., Rose, J. H., McIntosh, J. M., Ferris, M. J. and Jones, S. R. (2015). Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience 284: 854-864. 

  31. Sun, H., Calipari, E. S., Beveridge, T. J., Jones, S. R. and Chen, R. (2015). The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience 307: 253-261. 

  32. Ferris, M. J., Calipari, E. S., Rose, J. H., Siciliano, C. A., Sun, H., Chen, R. and Jones, S. R. (2015). A Single Amphetamine Infusion Reverses Deficits in Dopamine Nerve-Terminal Function Caused by a History of Cocaine Self-Administration. Neuropsychopharmacology 40(8): 1826-1836. 

  33. Willard, S. L., Uberseder, B., Clark, A., Daunais, J. B., Johnston, W. D., Neely, D., Massey, A., Williamson, J. D., Kraft, R. A., Bourland, J. D., Jones, S. R. and Shively, C. A. (2015). Long term sertraline effects on neural structures in depressed and nondepressed adult female nonhuman primates. Neuropharmacology 99: 369-378. 

  34. Pleil, K. E., Lowery-Gionta, E. G., Crowley, N. A., Li, C., Marcinkiewcz, C. A., Rose, J. H., McCall, N. M., Maldonado-Devincci, A. M., Morrow, A. L., Jones, S. R. and Kash, T. L. (2015). Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala. Neuropharmacology 99: 735-749. 

  35. Luderman, K. D., Chen, R., Ferris, M. J., Jones, S. R. and Gnegy, M. E. (2015). Protein kinase C beta regulates the D(2)-like dopamine autoreceptor. Neuropharmacology 89: 335-341. 

  36. Melchior, J. R., Ferris, M. J., Stuber, G. D., Riddle, D. R. and Jones, S. R. (2015). Optogenetic versus electrical stimulation of dopamine terminals in the nucleus accumbens reveals local modulation of presynaptic release. J Neurochem 134(5): 833-844. 

  37. Karkhanis, A. N., Alexander, N. J., McCool, B. A., Weiner, J. L. and Jones, S. R. (2015). Chronic social isolation during adolescence augments catecholamine response to acute ethanol in the basolateral amygdala. Synapse 69(8): 385-395.

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