Juan Rodríguez Vita
  • Group leader, CIPF
Research fields
  • Cancer Biology
Personal information


Ph.D. In Life Sciences (Discipline: Molecular Medicine), Universidad Autónoma de Madrid, 2007

Lab information



Publications (since 2005)

1. Alsina-Sanchis E, Mulfarth R, Moll I, Mogler C, Rodriguez-Vita J*, Fischer A*. Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages. Mol Cancer Res. 2020 Nov 2:molcanres.0650.2020. doi: 10.1158/1541-7786.MCR-20-0650.

2. Klose R., Prinz A., Tetzlaff F., Weis E., Moll I., Rodriguez-Vita J., Oka C., Korff T., Fischer A. Loss of the Serine Protease HTRA1 Impairs Smooth Muscle Cells Maturation. Sci Rep, 9 (1), 18224 2019.

3. Goossens P*, Rodriguez-Vita J*, Etzerodt A, Masse M, Rastoin O, Gouirand V, Ulas T, Papantonopoulou O, Van Eck M, Auphan-Anezin N, Bebien M, Verthuy C, Vu Manh TP, Turner M, Dalod M, Schultze JL, Lawrence T. Membrane Cholesterol Efflux Drives Tumor-Associated Macrophage Reprogramming and Tumor Progression. Cell Metab. 2019 Mar 21. pii: S1550-4131(19)30128-7. *Co-first authors. (Research article)

4. Ribera J*, Rodríguez-Vita J*, Cordoba B, Portolés I, Casals G, Casals E, Jiménez W, Puntes V, Morales-Ruiz M. Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats. PLoS One. 2019 Jun 24;14(6):e0218716. *Co-first authors. (Research article)

5. Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A. MPDZ promotes DLL4-induced Notch signaling during angiogenesis. Elife. 2018 Apr 5;7. pii: e32860. (Research article)

6. Rodriguez-Vita J, Tetzlaff F, Fischer A. Notch controls endothelial cells. Oncoscience. 2017 Jun 25;4(5-6):45-46. (Comment)

7. Rodriguez-Vita J, Fischer A. Notch Signaling facilitase crossing of endothelial barriers by tumor cells. Mol Cell Oncol. 2017 Apr 3;4(3):e1311828. (Comment)

8. Rodriguez-Vita J, Fischer A. Notch1 induces endothelial senescence and promotes tumor progression. Cell Cycle. 2017 May 19;16(10):911-912. (Comment)

9. Wieland E*, Rodriguez-Vita J*, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell. 2017 Mar 13;31(3):355-367. *Co-first authors. (Research article)

10. Morales-Ruiz M., Rodriguez-Vita J., Ribera J., Jimenez W. Pathophysiology of Portal Hypertension. Jan 2015. PanVascular Medicine. ISBN: 978-3-642-37077-9 (Print) 978-3-642-37078-6 (On-line) Pages 3631-3665 (Book chapter)

11. Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12865-70. (Research article)

12. Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodríguez-Vita J, Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jiménez W, Morales-Ruiz M. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. Liver Int. 2014 Feb 19. (Research article)

13. Rodriguez-Vita J, Morales-Ruiz M. Down the liver sinusoidal endothelial cell (LSEC) hole. Is there a role for lipid rafts in LSEC fenestration? Hepatology. 2013 Mar;57(3):1272-4. (Comment)

14. Rodrigues Díez R, Rodrigues-Díez R, Lavoz C, Rayego-Mateos S, Civantos E, Rodríguez-Vita J, Mezzano S, Ortiz A, Egido J, Ruiz-Ortega M. Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. PLoS One. 2010 Nov 30;5(11):e14145. (Research article)

15. Rodriguez-Vita J, Lawrence T. The resolution of inflammation and cancer. Cytokine Growth Factor Rev. 2010 Feb;21(1):61-5. (Review article)

16. Sánchez-López E, Rayego S, Rodrigues-Díez R, Rodriguez JS, Rodrigues-Díez R, Rodríguez-Vita J, Carvajal G, Aroeira LS, Selgas R, Mezzano SA, Ortiz A, Egido J, Ruiz-Ortega M. CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. J Am Soc Nephrol. 2009 Jul;20(7):1513-26. (Research article)

17. Rodríguez-Vita J, Sánchez-Galán E, Santamaría B, Sánchez-López E, Rodrigues-Díez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M. Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation. PLoS One. 2008;3(12):e3959. (Research article)

18. Rodrigues-Díez R, Carvajal-González G, Sánchez-López E, Rodríguez-Vita J, Rodrigues Díez R, Selgas R, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M. Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. Pharm Res. 2008 Oct;25(10):2447-61. (Research article)

19. Carvajal G, Rodríguez-Vita J, Rodrigues-Díez R, Sánchez-López E, Rupérez M, Cartier C, Esteban V, Ortiz A, Egido J, Mezzano SA, Ruiz-Ortega M. Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation. Kidney Int. 2008 Sep;74(5):585-95. (Research article)

20. Sanchez-Lopez E, Rodriguez-Vita J, Cartier C, Ruperez M, Esteban V, Carvajal G, Rodrigues-Diez R, Plaza JJ, Egido J, Ruiz-Ortega M. Inhibitory effect of interleukin-1- on Angiotensin II-induced connective tissue growth factor and type IV collagen production in cultured mesangial cells. Am J Physiol Renal Physiol. 2008 Jan;294(1):F149-60. (Research article)

21. Rupérez M, Rodrigues-Díez R, Blanco-Colio LM, Sánchez-López E, Rodríguez-Vita J, Esteban V, Carvajal G, Plaza JJ, Egido J, Ruiz-Ortega M. HMG-CoA reductase inhibitors decrease angiotensin II-induced vascular fibrosis: role of RhoA/ROCK and MAPK pathways. Hypertension. 2007 Aug;50(2):377-83. (Research article)

22. Marta Ruiz-Ortega, Juan Rodríguez-Vita, Elsa Sanchez-Lopez, Gisselle Carvajal and Jesús Egido. TGF β signaling in vascular fibrosis. Cardiovasc Res. 2007 May 1;74(2):196-206. (Review article)

23. Ruiz-Ortega M, Esteban V, Ruperez M, Sanchez-Lopez E, Rodriguez-Vita J, Carvajal G, Egido J. Renal and vascular hypertension-induced inflammation: role of angiotensin II. Curr Opin Nephrol Hypertens. 2006 Mar;15(2):159-66. (Review article)

24. M. Ruiz-Ortega, M Ruperez, V Esteban, J Rodriguez-Vita, E Sanchez-Lopez, G Carvajal, J Egido. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transplant. 2006 Nov 9 Jan;21(1):16-20. (Review article)

25. Rodriguez-Vita J, Ruiz-Ortega M, Rupérez M, Esteban V, Sanchez-López E, Plaza JJ, Egido J. Endothelin-1, via ETA receptor and independently of transforming growth factor-beta, increases the connective tissue growth factor in vascular smooth muscle cells. Circ Res. 2005 Jul 22;97(2):125-34. (Research article)

26. Rodríguez-Vita J, Sánchez-López E, Esteban V, Rupérez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005;111:2509-2517. (Research article)

27. V. Esteban, M. Ruperez BsC, E. Sánchez-López, J. Rodríguez-vita, O. Lorenzo, H Demaegdt, P. Vanderheyden, J. Egido, M. Ruiz-Ortega. Angiotensin IV activates the nuclear transcription factor-kappa B (NF-κB) and related genes in vascular smooth muscle cells. Circ Res.2005 May;13:965-973. (Research article)
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