Emmanuel Pinteaux
  • Division of Neuroscience and Experimental Neurology, Faculty of Biology, Medicine, and Health. University of Manchester, UK, UK,
Research fields
  • Stem cell
Personal information


PhD in Cellular and Molecular Neurobiology, Louis Pasteur University, Strasbourg, France, 1997

Current position 

Reader, Faculty of Biology, Medicine and Health, University of Manchester, UK, 2018-2018

Co-director of the Centre for Doctor Training in Regenerative Medicine, Centre for Doctor Training in Regenerative Medicine, University of Manchester, UK, 2016-2018

Course Leader of the Undergraduate Medical Programme (MBChB), Manchester Medical School, University of Manchester, UK, 2011-2018

Publications (since 2014)

  1. Redondo-Castro, E., Cunningham, C. J., Miller, J., Brown, H., Allan, S. M. and Pinteaux, E. (2018). Changes in the secretome of tri-dimensional spheroid-cultured human mesenchymal stem cells in vitro by interleukin-1 priming. Stem Cell Res Ther 9(1): 11. 

  2.  Thurgur, A., Pinteaux, E. (2018). Microglia in the neurovascular unit: blood-brain barrier-microglial interactions after central nervous system disorders. (unpublished). 

  3. Lepelletier, F. X., Mann, D. M., Robinson, A. C., Pinteaux, E. and Boutin, H. (2017). Early changes in extracellular matrix in Alzheimer's disease. Neuropathol Appl Neurobiol 43(2): 167-182. 

  4. Matsuwaki, T., Shionoya, K., Ihnatko, R., Eskilsson, A., Kakuta, S., Dufour, S., Schwaninger, M., Waisman, A., Muller, W., Pinteaux, E., Engblom, D. and Blomqvist, A. (2017). Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses. Brain Behav Immun 66: 165-176. 

  5. Mufazalov, I. A., Schelmbauer, C., Regen, T., Kuschmann, J., Wanke, F., Gabriel, L. A., Hauptmann, J., Muller, W., Pinteaux, E., Kurschus, F. C. and Waisman, A. (2017). IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. EMBO J 36(1): 102-115. 

  6. Redondo-Castro, E., Cunningham, C., Miller, J., Martuscelli, L., Aoulad-Ali, S., Rothwell, N. J., Kielty, C. M., Allan, S. M. and Pinteaux, E. (2017). Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro. Stem Cell Res Ther 8(1): 79. 

  7. Abdulaal, W. H., Walker, C. R., Costello, R., Redondo-Castro, E., Mufazalov, I. A., Papaemmanouil, A., Rothwell, N. J., Allan, S. M., Waisman, A., Pinteaux, E. and Muller, W. (2016). Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system. Eur J Immunol 46(4): 912-918. 

  8. Kangwantas, K., Pinteaux, E. and Penny, J. (2016). The extracellular matrix protein laminin-10 promotes blood-brain barrier repair after hypoxia and inflammation in vitro. J Neuroinflammation 13: 25.

  9. Mufazalov, I. A., Regen, T., Schelmbauer, C., Kuschmann, J., Muratova, A. M., Nikolaev, A., Muller, W., Pinteaux, E. and Waisman, A. (2016). Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells. PLoS One 11(8): e0161505. 

  10. Rajkovic, I., Denes, A., Allan, S. M. and Pinteaux, E. (2016). Emerging roles of the acute phase protein pentraxin-3 during central nervous system disorders. J Neuroimmunol 292: 27-33. 

  11. Salmeron, K., Aihara, T., Redondo-Castro, E., Pinteaux, E. and Bix, G. (2016). IL-1alpha induces angiogenesis in brain endothelial cells in vitro: implications for brain angiogenesis after acute injury. J Neurochem 136(3): 573-580. 

  12. Bruttger, J., Karram, K., Wortge, S., Regen, T., Marini, F., Hoppmann, N., Klein, M., Blank, T., Yona, S., Wolf, Y., Mack, M., Pinteaux, E., Muller, W., Zipp, F., Binder, H., Bopp, T., Prinz, M., Jung, S. and Waisman, A. (2015). Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. Immunity 43(1): 92-106. 

  13. Rodriguez-Grande, B., Varghese, L., Molina-Holgado, F., Rajkovic, O., Garlanda, C., Denes, A. and Pinteaux, E. (2015). Pentraxin 3 mediates neurogenesis and angiogenesis after cerebral ischaemia. J Neuroinflammation 12: 15. 

  14. Lenglet, S., Montecucco, F., Denes, A., Coutts, G., Pinteaux, E., Mach, F., Schaller, K., Gasche, Y. and Copin, J. C. (2014). Recombinant tissue plasminogen activator enhances microglial cell recruitment after stroke in mice. J Cereb Blood Flow Metab 34(5): 802-812. 

  15. Rodriguez-Grande, B., Swana, M., Nguyen, L., Englezou, P., Maysami, S., Allan, S. M., Rothwell, N. J., Garlanda, C., Denes, A. and Pinteaux, E. (2014). The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury. J Cereb Blood Flow Metab 34(3): 480-488. 

  16. Garcia-Ovejero, D., Arevalo-Martin, A., Navarro-Galve, B., Pinteaux, E., Molina-Holgado, E. and Molina-Holgado, F. (2013). Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1beta (IL-1beta) signalling. Biochem Soc Trans 41(6): 1577-1582. 

  17. Rodriguez-Grande, B., Blackabey, V., Gittens, B., Pinteaux, E. and Denes, A. (2013). Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia. Brain Behav Immun 29: 51-61. 

  18. Summers, L., Kangwantas, K., Rodriguez-Grande, B., Denes, A., Penny, J., Kielty, C. and Pinteaux, E. (2013). Activation of brain endothelial cells by interleukin-1 is regulated by the extracellular matrix after acute brain injury. Mol Cell Neurosci 57: 93-103. 

  19. Allen, C., Thornton, P., Denes, A., McColl, B. W., Pierozynski, A., Monestier, M., Pinteaux, E., Rothwell, N. J. and Allan, S. M. (2012). Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA. J Immunol 189(1): 381-392. 

  20. Leow-Dyke, S., Allen, C., Denes, A., Nilsson, O., Maysami, S., Bowie, A. G., Rothwell, N. J. and Pinteaux, E. (2012). Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J Neuroinflammation 9: 230. 

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