Tullio Florio 1 protocol

Federica Barbieri Internal Medicine, Pharmacology Unit, University of Genova, Italy
1 protocol

Roberto Würth 1 protocol

Alessandra Pattarozzi
  • Internal Medicine, Pharmacology Unit, University of Genova, Italy
Research focus
  • Cancer biology
  • 1 Author merit


Biotechnologist., Università degli Studi di Genova, Italy, 1998-2003

Current position

Researcher, Department of Internal Medicine, Università degli Studi di Genova, Italy, 2003

Publications (since 2008)

  1. Gatti, M., Solari, A., Pattarozzi, A., Campanella, C., Thellung, S., Maniscalco, L., De Maria, R., Wurth, R., Corsaro, A., Bajetto, A., Ratto, A., Ferrari, A., Daga, A., Barbieri, F. and Florio, T. (2018). In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity. Exp Cell Res 363(1): 48-64.
  2. Baldassari, S., Solari, A., Zuccari, G., Drava, G., Pastorino, S., Fucile, C., Marini, V., Daga, A., Pattarozzi, A., Ratto, A., Ferrari, A., Mattioli, F., Barbieri, F., Caviglioli, G. and Florio, T. (2018). Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects. Sci Rep 8(1): 3929.
  3. Pattarozzi, A., Carra, E., Favoni, R. E., Wurth, R., Marubbi, D., Filiberti, R. A., Mutti, L., Florio, T., Barbieri, F. and Daga, A. (2017). The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells. Stem Cell Res Ther 8(1): 119.
  4. Bajetto, A., Pattarozzi, A., Corsaro, A., Barbieri, F., Daga, A., Bosio, A., Gatti, M., Pisaturo, V., Sirito, R. and Florio, T. (2017). Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors. Front Cell Neurosci 11: 312.
  5. Thellung, S., Favoni, R. E., Wurth, R., Nizzari, M., Pattarozzi, A., Daga, A., Florio, T. and Barbieri, F. (2016). Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies. Curr Drug Targets 17(7): 824-849.
  6. Gatti, M., Wurth, R., Vito, G., Pattarozzi, A., Campanella, C., Thellung, S., Maniscalco, L., De Maria, R., Villa, V., Corsaro, A., Nizzari, M., Bajetto, A., Ratto, A., Ferrari, A., Barbieri, F. and Florio, T. (2016). Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization. Jpn J Vet Res 64(2): 101-112.
  7. Corsaro, A., Bajetto, A., Thellung, S., Begani, G., Villa, V., Nizzari, M., Pattarozzi, A., Solari, A., Gatti, M., Pagano, A., Wurth, R., Daga, A., Barbieri, F. and Florio, T. (2016). Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells. Oncotarget 7(25): 38638-38657.
  8. Angeletti, F., Fossati, G., Pattarozzi, A., Wurth, R., Solari, A., Daga, A., Masiello, I., Barbieri, F., Florio, T. and Comincini, S. (2016). Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells. Front Mol Neurosci 9: 107.
  9. Banelli, B., Carra, E., Barbieri, F., Wurth, R., Parodi, F., Pattarozzi, A., Carosio, R., Forlani, A., Allemanni, G., Marubbi, D., Florio, T., Daga, A. and Romani, M. (2015). The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma. Cell Cycle 14(21): 3418-3429.
  10. Barbieri, F., Thellung, S., Ratto, A., Carra, E., Marini, V., Fucile, C., Bajetto, A., Pattarozzi, A., Wurth, R., Gatti, M., Campanella, C., Vito, G., Mattioli, F., Pagano, A., Daga, A., Ferrari, A. and Florio, T. (2015). In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors. BMC Cancer 15: 228.
  11. Giannoni, P., Pietra, G., Travaini, G., Quarto, R., Shyti, G., Benelli, R., Ottaggio, L., Mingari, M. C., Zupo, S., Cutrona, G., Pierri, I., Balleari, E., Pattarozzi, A., Calvaruso, M., Tripodo, C., Ferrarini, M. and de Totero, D. (2014). Chronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages. Haematologica 99(6): 1078-1087.
  12. Porcile, C., Di Zazzo, E., Monaco, M. L., D'Angelo, G., Passarella, D., Russo, C., Di Costanzo, A., Pattarozzi, A., Gatti, M., Bajetto, A., Zona, G., Barbieri, F., Oriani, G., Moncharmont, B., Florio, T. and Daniele, A. (2014). Adiponectin as novel regulator of cell proliferation in human glioblastoma. J Cell Physiol 229(10): 1444-1454.
  13. Gritti, M., Wurth, R., Angelini, M., Barbieri, F., Peretti, M., Pizzi, E., Pattarozzi, A., Carra, E., Sirito, R., Daga, A., Curmi, P. M., Mazzanti, M. and Florio, T. (2014). Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current. Oncotarget 5(22): 11252-11268.
  14. Wurth, R., Pattarozzi, A., Gatti, M., Bajetto, A., Corsaro, A., Parodi, A., Sirito, R., Massollo, M., Marini, C., Zona, G., Fenoglio, D., Sambuceti, G., Filaci, G., Daga, A., Barbieri, F. and Florio, T. (2013). Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt. Cell Cycle 12(1): 145-156.
  15. Barbieri, F., Bajetto, A., Pattarozzi, A., Gatti, M., Wurth, R., Thellung, S., Corsaro, A., Villa, V., Nizzari, M. and Florio, T. (2013). Peptide receptor targeting in cancer: the somatostatin paradigm. Int J Pept 2013: 926295.
  16. Carra, E., Barbieri, F., Marubbi, D., Pattarozzi, A., Favoni, R. E., Florio, T. and Daga, A. (2013). Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures. Cell Cycle 12(3): 491-500.
  17. Bajetto, A., Porcile, C., Pattarozzi, A., Scotti, L., Aceto, A., Daga, A., Barbieri, F. and Florio, T. (2013). Differential role of EGF and BFGF in human GBM-TIC proliferation: relationship to EGFR-tyrosine kinase inhibitor sensibility. J Biol Regul Homeost Agents 27(1): 143-154.
  18. Gatti, M., Pattarozzi, A., Bajetto, A., Wurth, R., Daga, A., Fiaschi, P., Zona, G., Florio, T. and Barbieri, F. (2013). Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity. Toxicology 314(2-3): 209-220.
  19. Barbieri F., Bajetto A., Pattarozzi A., Gatti M., Würth R., Porcile C., Thellung S., Corsaro A., Villa V., Nizzari M. and Florio T. (2011) The chemokine SDF1/CXCL12: a novel autocrine/paracrine factor involved in pituitary adenoma development. The open Neuroendocrinology Journal 4: 64-76.
  20. Wurth, R., Barbieri, F., Bajetto, A., Pattarozzi, A., Gatti, M., Porcile, C., Zona, G., Ravetti, J. L., Spaziante, R. and Florio, T. (2011). Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature. J Neuroimmunol 234(1-2): 115-123.
  21. Gatto, F., Barbieri, F., Castelletti, L., Arvigo, M., Pattarozzi, A., Annunziata, F., Saveanu, A., Minuto, F., Castellan, L., Zona, G., Florio, T. and Ferone, D. (2011). In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5. Pituitary 14(2): 141-147.
  22. Giannoni, P., Scaglione, S., Quarto, R., Narcisi, R., Parodi, M., Balleari, E., Barbieri, F., Pattarozzi, A., Florio, T., Ferrini, S., Corte, G. and de Totero, D. (2011). An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease. Haematologica 96(7): 1015-1023.
  23. Barbieri, F., Wurth, R., Favoni, R. E., Pattarozzi, A., Gatti, M., Ratto, A., Ferrari, A., Bajetto, A. and Florio, T. (2011). Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets. Biochem Pharmacol 82(10): 1467-1477.
  24. Favoni, R. E., Pattarozzi, A., Lo Casto, M., Barbieri, F., Gatti, M., Paleari, L., Bajetto, A., Porcile, C., Gaudino, G., Mutti, L., Corte, G. and Florio, T. (2010). Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. Curr Cancer Drug Targets 10(2): 176-191.
  25. Iuliano, R., Raso, C., Quintiero, A., Pera, I. L., Pichiorri, F., Palumbo, T., Palmieri, D., Pattarozzi, A., Florio, T., Viglietto, G., Trapasso, F., Croce, C. M. and Fusco, A. (2009). The eighth fibronectin type III domain of protein tyrosine phosphatase receptor J influences the formation of protein complexes and cell localization. J Biochem 145(3): 377-385.
  26. Griffero, F., Daga, A., Marubbi, D., Capra, M. C., Melotti, A., Pattarozzi, A., Gatti, M., Bajetto, A., Porcile, C., Barbieri, F., Favoni, R. E., Lo Casto, M., Zona, G., Spaziante, R., Florio, T. and Corte, G. (2009). Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. J Biol Chem 284(11): 7138-7148.
  27. Barbieri, F., Pattarozzi, A., Gatti, M., Aiello, C., Quintero, A., Lunardi, G., Bajetto, A., Ferrari, A., Culler, M. D. and Florio, T. (2009). Differential efficacy of SSTR1, -2, and -5 agonists in the inhibition of C6 glioma growth in nude mice. Am J Physiol Endocrinol Metab 297(5): E1078-1088.
  28. Pattarozzi, A., Gatti, M., Barbieri, F., Wurth, R., Porcile, C., Lunardi, G., Ratto, A., Favoni, R., Bajetto, A., Ferrari, A. and Florio, T. (2008). 17beta-estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment. Mol Pharmacol 73(1): 191-202.
  29. Barbieri, F., Bajetto, A., Stumm, R., Pattarozzi, A., Porcile, C., Zona, G., Dorcaratto, A., Ravetti, J. L., Minuto, F., Spaziante, R., Schettini, G., Ferone, D. and Florio, T. (2008). Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clin Cancer Res 14(16): 5022-5032.
  30. Barbieri, F., Pattarozzi, A., Gatti, M., Porcile, C., Bajetto, A., Ferrari, A., Culler, M. D. and Florio, T. (2008). Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2. Endocrinology 149(9): 4736-4746.
1 Protocol published
Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas
Authors:  Roberto Würth, Alessandra Pattarozzi, Federica Barbieri and Tullio Florio, date: 04/05/2018, view: 5691, Q&A: 0
Pituitary adenomas are among the more frequent intracranial tumors usually treated with both surgical and pharmacological–based on somatostatin and dopamine agonists–approaches. Although mostly benign tumors, the occurrence of invasive behaviors is ...
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