Amberley Stephens Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge
7 protocols

Amriti Lulla UT MD Anderson Cancer Center
6 protocols

Kristin Shingler University of Minnesota School of Dentistry
38 protocols

Luis Alberto Vargas Institute for Immunology and Informatics. University of Rhode Island
21 protocols

Reviewer
Mohan Babu
  • Post-Doc, Stanford University
Research focus
  • Molecular biology
  • Leveraging Omics approaches to delineate cardiovascular disease mechanism

Education

PhD, Ita suomen yliopisto, 2019

Lab information

Snyder Lab

Publications

https://www.scopus.com/authid/detail.uri?authorId=10142549900
1. Babu M, Devi T, Mäkinen P, Örd T, Aavik E, Kaikkonen M, Ylä-Herttuala S. ApoA-I nanotherapy rescues post-ischemic vascular maladaptation by modulating endothelial cell and macrophage phenotypes in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. 2022

2. Aavik E, Babu M, Ylä-Herttuala S. DNA methylation processes in atherosclerotic plaque. Atherosclerosis 281 (2019) 168–179.

3. A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes. Diabetes. https://doi.org/10.2337/db17-0914 (2018) (part of SUMMIT consortium).

4. Devi T *, Babu M *, Mäkinen P, Kaikkonen M, Heinoniemi M, Laakso H, Ylä-Herttuala E, Rieppo L, Liimatainen T, Naumenko N, Tavi P, Ylä-Herttuala S. Aggravated post-infarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation. (* Shared first author). Am J Pathol. 2017:187: 2659-2673.

5. Babu M, Devi T, Mäkinen P, Kaikkonen M, Lesch H, Junttila S, Laiho A, Ghimire B, Gyenesei A, Yla-Herttuala S. Differential promoter methylation of macrophage genes is associated with impaired vascular growth in ischemic muscles of hyperlipidemic and type 2 diabetic mice: A Genome-Wide Promoter Methylation Study. Circulation Research. 2015;117:289–299.

6. Bhardwaj S, Roy H, Babu M, Shibuya M, Yla-Herttuala S. Adventitial gene transfer of VEGFR-2 specific VEGF-E chimera induces MCP-1 expression in vascular smooth muscle cells and enhances neointimal formation. Atherosclerosis. 2011; 219(1): 84-91.

7. Roy H, Bhardwaj S, Babu M, Lähteenvuo J, Ylä-Herttuala S. VEGF-D∆N∆C Mediated Angiogenesis in Skeletal Muscles of Diabetic WHHL Rabbits. Eur J Clin Invest. 2010; 40(5): 422-32.

8. Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes. Hum Gene Ther. 2009; 20(12): 1679-86.

9. Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, Heikura T, Turpeinen S, Laidinen S, Takalo T, Ylä-Herttuala S. 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and down regulation of VEGF receptor 2 expression. Circulation Research. 2008; 102(2): 177-84.

10. Räty S, Piironen A, Babu M, Pelli H , Sand J, Uotila S, Nordback I, Herzig KH. Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish hereditary pancreatitis family. Scand J Gastroenterol. 2007; 42(8):1000-5.

11. Roy H, Bhardwaj S, Babu M, Kokina I, Uotila S, Ahtialansaari T, Laitinen T, Hakumaki J, Laakso M, Herzig KH, Yla-Herttuala S. VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits. FASEB J. 2006; 20(12):2159-61.

12. Roy H, Bhardwaj S, Babu M, Jauhiainen S, Herzig KH, Haisma HJ, Carmeliet P, Alitalo K, Ylä-Herttuala S . Adenovirus mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via up regulation of the expression of endogenous vascular endothelial growth factor-A. Human Gene Therapy. 2005; 16(12):1422-8.

13. Kumar A, Babu M, Kimberling WJ, Venkatesh CP. Genetic analysis of a four-generation Indian family with Usher syndrome: a novel insertion mutation in MYO7A. Molecular Vision. 2004; 10:910-6.

14. Kumar A, Babu M, Raghunath A, Venkatesh CP. Genetic analysis of a five generation Indian family with BPES: A novel missense mutation (p. Y215C). Molecular Vision. 2004; 10:445-9.

15. Kumar A, Blanton SH, Babu M, Markandaya M, Girimaji SC.Genetic analysis of primary microcephaly in Indian families: novel ASPM mutations. Clin Genet. 2004; 66(4):341-8.
7 Protocols reviewed
ATAC-Seq of a Single Myofiber from Mus musculus
Authors:  Korin Sahinyan, Darren M. Blackburn and Vahab D. Soleimani, date: 06/20/2022, view: 2028, Q&A: 0

Chromatin accessibility is a key determinant of gene expression that can be altered under different physiological and disease conditions. Skeletal muscle is made up of myofibers that are highly plastic and adaptive. Therefore, assessing the

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Characterization of the Elasticity of CD4+ T Cells: An Approach Based on Peak Force Quantitative Nanomechanical Mapping
Authors:  Philipp Jung, Xiangda Zhou, Sandra Iden, Bin Qu and Markus Bischoff, date: 04/20/2022, view: 1416, Q&A: 0

CD4+ T cells are essential players in orchestrating the specific immune response against intracellular pathogens, and in inhibiting tumor development in an early stage. The activation of T cells is triggered by engagement of T cell receptors (TCRs).

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