Bin Li
  • Shanghai Institute of Immunology
Research focus
  • Microbiology
Personal information


Ph.D., Peking University, China, 2001

Current position

Senior Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, China
Distinguished Professor, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, China

Publications (Since 2016)

  1. Jiang, W., Zhou, X., Li, Z., Liu, K., Wang, W., Tan, R., Cong, X., Shan, J., Zhan, Y., Cui, Z., Jiang, L., Li, Q., Shen, S., Bai, M., Cheng, Y., Li, B., Tan, M., Ma, D. K., Liu, J. O. and Dang, Y. (2018). Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin. Blood 131(12): 1325-1336. 
  2. Zhang, L., He, X., Li, F., Pan, H., Huang, X., Wen, X., Zhang, H., Li, B., Ge, S., Xu, X., Jia, R. and Fan, X. (2018). The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. J Exp Clin Cancer Res 37(1): 15. 
  3. Lu, Y., Kim, N. M., Jiang, Y. W., Zhang, H., Zheng, D., Zhu, F. X., Liang, R., Li, B. and Xu, H. X. (2018). Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol 175(7): 1085-1099. 
  4. Tong, J., Cao, G., Zhang, T., Sefik, E., Amezcua Vesely, M. C., Broughton, J. P., Zhu, S., Li, H., Li, B., Chen, L., Chang, H. Y., Su, B., Flavell, R. A. and Li, H. B. (2018). m(6)A mRNA methylation sustains Treg suppressive functions. Cell Res 28(2): 253-256. 
  5. Shan, J., Zhao, B., Shan, Z., Nie, J., Deng, R., Xiong, R., Tsun, A., Pan, W., Zhao, H., Chen, L., Jin, Y., Qian, Z., Lui, K., Liang, R., Li, D., Sun, B., Lavillette, D., Xu, K. and Li, B. (2017). Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog 13(12): e1006773. 
  6. Li, P., Li, Y., Zhu, L., Yang, Z., He, J., Wang, L., Shang, Q., Pan, H., Wang, H., Ma, X., Li, B., Fan, X., Ge, S., Jia, R. and Zhang, H. (2018). Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis. Biochim Biophys Acta Mol Basis Dis 1864(3): 709-720. 
  7. Shi, B., Geng, J., Wang, Y. H., Wei, H., Walters, B., Li, W., Luo, X., Stevens, A., Pittman, M., Li, B., Thompson, S. R. and Hu, H. (2018). Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol 200(2): 586-594. 
  8. Zhang, P., Wang, H., Luo, X., Liu, H., Lu, B., Li, T., Yang, S., Gu, Q., Li, B., Wang, F. and Sun, X. (2018). MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization. Inflammation 41(1): 143-153.
  9. Li, Y., Strick-Marchand, H., Lim, A. I., Ren, J., Masse-Ranson, G., Dan, L., Jouvion, G., Rogge, L., Lucas, S., Bin, L. and Di Santo, J. P. (2017). Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nat Commun 8(1): 1762. 
  10. Fang, S., Huang, Y., Zhong, S., Li, Y., Zhang, Y., Li, Y., Sun, J., Liu, X., Wang, Y., Zhang, S., Xu, T., Sun, X., Gu, P., Li, D., Zhou, H., Li, B. and Fan, X. (2017). Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy. J Clin Endocrinol Metab 102(11): 4273-4283. 
  11. Luo, X., Zhu, F., Chen, Z., Li, D. and Li, B. (2017). Regulation of Metabolism Across Different Subsets of T Cells in Cancer. Adv Exp Med Biol 1011: 197-209. 
  12. Zhu, F., Wang, A., Li, Y., Liang, R., Li, D. and Li, B. (2017). Adipose Tissue-Resident Regulatory T Cells. Adv Exp Med Biol 1011: 153-162. 
  13. Guo, Z., Xu, P., Ge, S., Zhang, C., Zheng, X., Xu, J., Liu, Z., Li, B. and Ge, S. (2017). Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells. Int J Mol Med 40(4): 979-986. 
  14. Wang, S., Li, Y., Zhu, F., Lin, F., Luo, X., Zhao, B., Zhang, P., Li, D., Gao, Y., Liang, R., Liu, L., Tsun, A., Yuan, X., Wu, K. and Li, B. (2017). DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells. FEBS Lett 591(13): 1929-1939. 
  15. Lin, R., Nie, J., Ren, J., Liang, R., Li, D., Wang, P., Gao, C., Zhuo, C., Yang, C. and Li, B. (2017). USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett 591(12): 1677-1686. 
  16. Ma, S., Wan, X., Deng, Z., Shi, L., Hao, C., Zhou, Z., Zhou, C., Fang, Y., Liu, J., Yang, J., Chen, X., Li, T., Zang, A., Yin, S., Li, B., Plumas, J., Chaperot, L., Zhang, X., Xu, G., Jiang, L., Shen, N., Xiong, S., Gao, X., Zhang, Y. and Xiao, H. (2017). Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med 214(5): 1471-1491. 
  17. Chen, Y., Wang, L., Jin, J., Luan, Y., Chen, C., Li, Y., Chu, H., Wang, X., Liao, G., Yu, Y., Teng, H., Wang, Y., Pan, W., Fang, L., Liao, L., Jiang, Z., Ge, X., Li, B. and Wang, P. (2017). p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. J Exp Med 214(4): 991-1010. 
  18. Li, H., Zhou, Z. Q., Yang, Z. R., Tong, D. N., Guan, J., Shi, B. J., Nie, J., Ding, X. T., Li, B., Zhou, G. W. and Zhang, Z. Y. (2017). MicroRNA-191 acts as a tumor promoter by modulating the TET1-p53 pathway in intrahepatic cholangiocarcinoma. Hepatology 66(1): 136-151. 
  19. Jin, J., Liu, J., Chen, C., Liu, Z., Jiang, C., Chu, H., Pan, W., Wang, X., Zhang, L., Li, B., Jiang, C., Ge, X., Xie, X. and Wang, P. (2016). The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nat Commun 7: 13594. 
  20. Li, Y., Lu, Y., Wang, S., Han, Z., Zhu, F., Ni, Y., Liang, R., Zhang, Y., Leng, Q., Wei, G., Shi, G., Zhu, R., Li, D., Wang, H., Zheng, S. G., Xu, H., Tsun, A. and Li, B. (2016). USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun 7: 13559. 
  21. Li, Y. and Li, B. (2016). A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity. EBioMedicine 13: 7-8. 
  22. Fang, S., Huang, Y., Wang, S., Zhang, Y., Luo, X., Liu, L., Zhong, S., Liu, X., Li, D., Liang, R., Miranda, P., Gu, P., Zhou, H., Fan, X. and Li, B. (2016). IL-17A Exacerbates Fibrosis by Promoting the Proinflammatory and Profibrotic Function of Orbital Fibroblasts in TAO. J Clin Endocrinol Metab 101(8): 2955-2965. 
  23. Xu, A., Liu, Y., Chen, W., Wang, J., Xue, Y., Huang, F., Rong, L., Lin, J., Liu, D., Yan, M., Li, Q. Z., Li, B., Song, J., Olsen, N. and Zheng, S. G. (2016). TGF-beta-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol 196(9): 3631-3641.
  24. Lu, Y., Cai, S., Nie, J., Li, Y., Shi, G., Hao, J., Fu, W., Tan, H., Chen, S., Li, B. and Xu, H. (2016). The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma. Biochem Pharmacol 100: 61-72. 
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