Shaarika Sarasija
  • Post-Doc, University of Ottawa
Research fields
  • Cell Biology, Molecular Biology, Neuroscience
Personal information


PhD, Albany Medical College, 2017

Research focus

GPCR, Alzheimer's Disease, Neurodegeneration, Presenilin, Calcium, Mitochondria, Aging, C. elegans, Mice

1. Abd-Elrahman KS, Sarasija S, Colson TL, and Ferguson SSG. A M1 muscarinic acetylcholine receptor positive allosteric modulator improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice. Br J Pharmacol (Under review)
2. Abd-Elrahman KS, Sarasija S, and Ferguson SSG. The role of neuroglial metabotropic glutamate receptors in Alzheimer’s disease. Curr Neuropharmacol. (Accepted)
3. Ryan KC, Ashkavand Z, Sarasija S, Laboy JT, Samarakoon R, Norman KR. Ryan KC, Ashkavand Z, Sarasija S, Laboy JT, Samarakoon R, Norman KR. Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration. Aging Cell (2021), e13472
4. Ashkavand Z, Sarasija S, Ryan KC, Laboy JT, Norman KR. Corrupted ER-mitochondrial calcium homeostasis promotes the collapse of proteostasis. Aging Cell. 2020 Jan;19(1)
5. Sarasija S, Norman KR. Measurement of oxygen consumption rates in intact Caenorhabditis elegans. J. Vis. Exp. 2019 (144), e59277
6. Sarasija S, Norman KR. Role of presenilin in mitochondrial oxidative stress and neurodegeneration in Caenorhabditis elegans. Antioxidants 2018 7(9), 111
7. Sarasija S, Laboy JT, Bonner J, Tang Y, Norman KR. Mutations in presenilin cause defects in mitochondrial calcium homeostasis and metabolic activity resulting in neurodegeneration. eLIFE 2018 7: e33052.
Research Highlight: Clark N. Alternative model for alternative hypothesis. Lab Animal 2018 47(231)
8. Sarasija S, Norman KR. H2DCFDA fluorescence measurement of ROS in Caenorhabditis elegans. Bio-Protocol 2018 8(7)
9. Sarasija S, Norman KR. Mitochondrial morphology analysis in in Caenorhabditis elegans. Bio-Protocol 2018 8(7)
10. Sarasija S, Norman KR. A γ-secretase independent role for presenilin in calcium homeostasis impacts mitochondrial function and morphology in Caenorhabditis elegans. Genetics. 2015; 201(4):1453-66.
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