KENNETH NORMAN Department of Regenerative and Cancer Cell Biology, ALBANY MEDICAL COLLEGE, USA, USA,
2 protocols
Alexandra Gros CNES - University of Bordeaux (IMN)
7 protocols

Edgar Soria-Gomez Faculty of Medicine and Nursery, University of the Basque Country
27 protocols

Marina Allerborn Université Claude Bernard Lyon 1
6 protocols

Oneil Bhalala The Royal Melbourne Hospital
64 protocols

Shaarika Sarasija
  • Post-Doc, University of Ottawa
Research focus
  • GPCR, Alzheimer's Disease, Neurodegeneration, Presenilin, Calcium, Mitochondria, Aging, C. elegans, Mice
  • 2 Author merit


PhD, Albany Medical College, 2017

1. Abd-Elrahman KS, Sarasija S, Colson TL, and Ferguson SSG. A M1 muscarinic acetylcholine receptor positive allosteric modulator improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice. Br J Pharmacol (Under review)
2. Abd-Elrahman KS, Sarasija S, and Ferguson SSG. The role of neuroglial metabotropic glutamate receptors in Alzheimer’s disease. Curr Neuropharmacol. (Accepted)
3. Ryan KC, Ashkavand Z, Sarasija S, Laboy JT, Samarakoon R, Norman KR. Ryan KC, Ashkavand Z, Sarasija S, Laboy JT, Samarakoon R, Norman KR. Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration. Aging Cell (2021), e13472
4. Ashkavand Z, Sarasija S, Ryan KC, Laboy JT, Norman KR. Corrupted ER-mitochondrial calcium homeostasis promotes the collapse of proteostasis. Aging Cell. 2020 Jan;19(1)
5. Sarasija S, Norman KR. Measurement of oxygen consumption rates in intact Caenorhabditis elegans. J. Vis. Exp. 2019 (144), e59277
6. Sarasija S, Norman KR. Role of presenilin in mitochondrial oxidative stress and neurodegeneration in Caenorhabditis elegans. Antioxidants 2018 7(9), 111
7. Sarasija S, Laboy JT, Bonner J, Tang Y, Norman KR. Mutations in presenilin cause defects in mitochondrial calcium homeostasis and metabolic activity resulting in neurodegeneration. eLIFE 2018 7: e33052.
Research Highlight: Clark N. Alternative model for alternative hypothesis. Lab Animal 2018 47(231)
8. Sarasija S, Norman KR. H2DCFDA fluorescence measurement of ROS in Caenorhabditis elegans. Bio-Protocol 2018 8(7)
9. Sarasija S, Norman KR. Mitochondrial morphology analysis in in Caenorhabditis elegans. Bio-Protocol 2018 8(7)
10. Sarasija S, Norman KR. A γ-secretase independent role for presenilin in calcium homeostasis impacts mitochondrial function and morphology in Caenorhabditis elegans. Genetics. 2015; 201(4):1453-66.
2 Protocols published
Analysis of Mitochondrial Structure in the Body Wall Muscle of Caenorhabditis elegans
Authors:  Shaarika Sarasija and Kenneth R. Norman, date: 04/05/2018, view: 7294, Q&A: 0
Mitochondrial function is altered in various pathologies, highlighting the crucial role mitochondria plays in maintaining cellular homeostasis. Mitochondrial structure undergoes constant fission and fusion in response to changing cellular ...
Measurement of ROS in Caenorhabditis elegans Using a Reduced Form of Fluorescein
Authors:  Shaarika Sarasija and Kenneth R. Norman, date: 04/05/2018, view: 5054, Q&A: 0
Oxidative stress is implicated in the pathogenesis of various neurodegenerative diseases, including Alzheimer’s disease. Oxidative stress is a result of a disruption of the equilibrium between antioxidants and oxidants, in favor of oxidants. Since ...
7 Protocols reviewed
Ethanol-induced Sedative Behavior: An Assay to Investigate Increased Dopamine Signaling in Caenorhabditis elegans
Authors:  Anuradha Singh, Kavita Babu and Pratima Pandey, date: 07/05/2021, view: 1645, Q&A: 0

Dopamine (DA) signaling affects locomotion, feeding, learning, and memory in C. elegans. Various assays have been developed to study the proteins involved in these behaviors; however, these assays show behavioral output only when there is a drastic

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Enriched Environment Procedures for Rodents: Creating a Standardized Protocol for Diverse Enrichment to Improve Consistency across Research Studies
Authors:  Bruce C. Harland and John C. Dalrymple-Alford, date: 06/05/2020, view: 2284, Q&A: 0
Exposure to environmental enrichment has beneficial effects on learning and memory, diverse neurobiological effects, and promotes recovery of function after brain injury. The effect of enrichment is produced by a combination of increased social ...
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