Alessandro Didonna East Carolina University
73 protocols

Alexandros Alexandratos National and Kapodistrian University of Athens
65 protocols

Gal Haimovich Weizmann Institute of Science Rehovot
123 protocols

Juan Facundo Ayala Instituto de Nanociencia y Nanotecnología
32 protocols

  • Research scientist, Buck Institute for Research on Aging
Research focus
  • Infectious Disease
    Innate Immunity
    Advanced glycation
    Metabolic disorders


Ph.D, Alagappa University, 2013

Lab information

Kapahi Lab

1. Sankara Naynar Palani*, Durai Sellegounder*, Yiyong Liu The longevity response to warm temperature is neurally controlled via the regulation of collagen genes doi: (*Equal contribution as the first author).
2. Phillip W, Shawndra W, Jan W, Chia-Hui C, Durai S, Isabel B, Yiyong L, Jingru S (2021) The neuropeptide receptor NMUR-1 regulates the specificity of C. elegans innate immunity against pathogen infection biorxiv doi: (Accepted in Cell reports 2022)
3. Durai S, Parisa Z, Misagh R, Mahdi T, Pankaj K (2021) Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age dependent COVID-19 morbidity and mortality. A review and hypothesis International Immunopharmacology, (Accepted, in press)
4. Amit K, Durai S, Jitendra K, Manish C,Miguel V, Shankar J. C, Anand R, Christopher N, T. Harshani P, Rachel B, Julie A, Gordon L, Pankaj K (2021). Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans. Aging Cell (
5. Durai S, Yiyong L, Phillip W, Chia-Hui C, David L, and Jingru S (2019) Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection. Science Advances. 5, eaaw4717.
6. Durai S *, Chung-Hsiang Y *, Phillip W, Yiyong L and Jingru S (2018) Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans. mBio 9: e01645-18
(*Equal contribution as the first author).
7. Durai S, Yugantak R G, Murugananthkumar R, Senthilkumaran B (2018) Enterotoxic effects of Aeromonas hydrophila infection in the catfish, Clarias gariepinus: Biochemical, histological and proteome analyses. Veterinary Immunology and Immunopathology 204, 1-10.
8. Yiyong L, Durai S, and Jingru S (2016) Neuronal GPCR OCTR-1 regulates innate immunity by controlling protein synthesis in Caenorhabditis elegans Scientific Reports. 6, 36832.
9. Yugantak R G, Durai S, Monica K, Deepa S, Senthilkumaran B and Basavaraju Y (2016) Effect of copper nanoparticles exposure in the physiology of the common carp (Cyprinus carpio): Biochemical, histological and proteomic approaches. Aquaculture and Fisheries 1, 15-23.
10. Vigneshkumar B, Durai S, Suman K and Balamurugan K (2016) Proteome Analysis Reveals Translational Inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis. Journal of Proteomics 145, 141–152.
JebaMercy G*, Durai S*, Prithika U, Marudhupandiyan S, Pushpanjali D, Suman K and Balamurugan K (2016) Role of DAF-21 protein in Caenorhabditis elegans immunity against Proteus mirabilis infection. Journal of Proteomics 145, 81–90. (*Equal contribution as the first author)
11. Durai S, Nirpendra S, Suman K, and Balamurugan K, (2014) Proteomic investigation in Caenorhabditis elegans against Vibrio alginolyticus infection revealed regulation of cellular homeostasis proteins and their role in supporting the innate immune system, Proteomics 14:1820-32.
12. Durai S, Vigneshwari L and Balamurugan K (2013). Caenorhabditis elegans based in vivo screening of bioactive from marine sponge-associated bacteria against Vibrio alginolyticus Journal of Applied Microbiology 115 (6): 1329-1342.
13. Durai S, Pandian SK and Balamurugan K (2011). Changes in Caenorhabditis elegans exposed to Vibrio parahaemolyticus. Journal of Microbiology and Biotechnology. 21(10), 1026–1035.
14. Durai S, Pandian SK and Balamurugan K (2011). Establishment of Caenorhabditis elegans infection model for Vibrio alginolyticus. Journal of Basic Microbiology. 51(3):243-52.

Book Chapters
1. Durai S and Balamurugan K. Vibrio: Caenorhabditis elegans as a laboratory model for Vibrio infections In book: Food Microbiology Series Laboratory Models for Foodborne Infections, Chapter: 28 First Edition, Pages 413-426, Publisher: CRC Press, Taylor and Francis Group, Editor: Dongyou Liu.
2. Kamaladevi A, Sivamaruthi B, Durai S, Kesika P, Vigneshkumar B, JebaMercy G, and Balamurugan K Tug-of-war between host immunity and microbial pathogenesis using Caenorhabditis elegans as a model system In book: The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs, Chapter: Microbiology Book Series number#5, Volume 2 Publisher: Formatex Research Center, Editor: A. Méndez-Vilas.
3. K. Balamurugan, B. Sivamaruthi, S. Durai, P. Kesika, B. Vigneshkumar, G. JebaMercy, A. Kamaladevi, Prasanth M. Iyer, S. Marudhupandiyan, U. Prithika, L. Vigneshwari and S. Karutha Pandian (2013) Understanding Innate Immune Defenses Against Pathogens Using Model organism Caenorhabditis elegans, Microbial pathogens and strategies for combating them: science, technology and education Microbiology Book Series #5, Volume 3 Publisher: Formatex Research Center
6 Protocols reviewed
Quantification of Duloxetine in the Bacterial Culture and Medium to Study Drug-gut Microbiome Interactions
Authors:  Prasad B. Phapale, Sonja Blasche, Kiran R. Patil and Theodore Alexandrov, date: 11/05/2021, view: 1318, Q&A: 0

Expanding our understanding of drug-gut bacteria interactions requires high-throughput drug measurements in complex bacterial cultures. Quantification of drugs in the cultures, media, and cell pellets is prone to strong matrix effects. We have

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Fixation and Immunostaining of Endogenous Proteins or Post-translational Modifications in Caenorhabditis elegans
Authors:  Robert O'Hagan and Irini Topalidou, date: 10/05/2021, view: 1739, Q&A: 0

Although the advent of genetically-encoded fluorescent markers, such as the green fluorescent protein (GFP; Chalfie et al., 1994), has enabled convenient visualization of gene expression in vivo, this method is generally not effective for detecting

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