Eva A. Turley
  • LHSC, Canada
Research fields
  • Cancer biology
Personal information


PhD, University of British Columbia, Canada

Current position

Professor, Biochemistry, University of Western Ontario, Canada

Publications (since2013)

  1. McCarthy, J.B., El-Ashry, D., Turley, E.A. (2018). Hyaluronan, cancer-associated fibroblasts and the tumor microenvironment in malignant progression. Frontiers in cell and developmental biology
  2. Hauser-Kawaguchi, A., Luyt, L. G. and Turley, E. (2018). Design of peptide mimetics to block pro-inflammatory functions of HA fragments. Matrix Biol
  3. El Shatoury, M. G., DeYoung, L., Turley, E., Yazdani, A. and Dave, S. (2018). Early experimental results of using a novel delivery carrier, hyaluronan-phosphatidylethanolamine (HA-PE), which may allow simple bladder instillation of botulinum toxin A as effectively as direct detrusor muscle injection. J Pediatr Urol 14(2): 172 e171-172 e176.
  4. Tolg, C., Yuan, H., Flynn, S. M., Basu, K., Ma, J., Tse, K. C. K., Kowalska, B., Vulkanesku, D., Cowman, M. K., McCarthy, J. B. and Turley, E. A. (2017). Hyaluronan modulates growth factor induced mammary gland branching in a size dependent manner. Matrix Biol 63: 117-132.
  5. Bahrami, S.B., Tolg, C., Peart, T., Symonette, C., Veiseh, M., Umoh, J.U., Holdsworth, D.W., McCarthy, J.B., Luyt, L.G., Bissell, M.J., Yazdani, A., Turley, E,A. (2017). Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis. Integrative Biology 9(3) 223-237.  
  6. Thangavel, C., Boopathi, E., Liu, Y., Haber, A., Ertel, A., Bhardwaj, A., Addya, S., Williams, N., Ciment, S. J., Cotzia, P., Dean, J. L., Snook, A., McNair, C., Price, M., Hernandez, J. R., Zhao, S. G., Birbe, R., McCarthy, J. B., Turley, E. A., Pienta, K. J., Feng, F. Y., Dicker, A. P., Knudsen, K. E. and Den, R. B. (2017). RB Loss Promotes Prostate Cancer Metastasis. Cancer Res 77(4): 982-995.
  7. Klank, R.L., Decker, Grunke. SA., Bangasser, B.L., Forster, C.L., Price, M.A., Odde, T.J., SantaCruz, K.S., Rosenfeld, S.S., Canoll, P.D., Turley, E.A., McCarthy, J.B., Ohlfest, J.R,, Odde, D.J. (2017). Biphasic dependence of glioma survival and cell migration on CD44 expression level. Cell Reports 19(3)668.
  8. Turley, E. A., Wood, D. K. and McCarthy, J. B. (2016). Carcinoma Cell Hyaluronan as a "Portable" Cancerized Prometastatic Microenvironment. Cancer Res 76(9): 2507-2512.
  9. Goertzen, C. G., Dragan, M., Turley, E., Babwah, A. V. and Bhattacharya, M. (2016). KISS1R signaling promotes invadopodia formation in human breast cancer cell via beta-arrestin2/ERK. Cell Signal 28(3): 165-176.
  10. Schwertfeger, K. L., Cowman, M. K., Telmer, P. G., Turley, E. A. and McCarthy, J. B. (2015). Hyaluronan, Inflammation, and Breast Cancer Progression. Front Immunol 6: 236.
  11. Cowman, M. K., Lee, H. G., Schwertfeger, K. L., McCarthy, J. B. and Turley, E. A. (2015). The Content and Size of Hyaluronan in Biological Fluids and Tissues. Front Immunol 6: 261.
  12. Assayag-Asherie, N., Sever, D., Bogdani, M., Johnson, P., Weiss, T., Ginzberg, A., Perles, S., Weiss, L., Sebban, L. E., Turley, E. A., Okon, E., Raz, I. and Naor, D. (2015). Can CD44 Be a Mediator of Cell Destruction? The Challenge of Type 1 Diabetes. PLoS One 10(12): e0143589.
  13. Veiseh, M., Leith, S. J., Tolg, C., Elhayek, S. S., Bahrami, S. B., Collis, L., Hamilton, S., McCarthy, J. B., Bissell, M. J. and Turley, E. (2015). Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells. Front Cell Dev Biol 3: 63.
  14. Esguerra, K. V., Tolg, C., Akentieva, N., Price, M., Cho, C. F., Lewis, J. D., McCarthy, J. B., Turley, E. A. and Luyt, L. G. (2015). Identification, design and synthesis of tubulin-derived peptides as novel hyaluronan mimetic ligands for the receptor for hyaluronan-mediated motility (RHAMM/HMMR). Integr Biol (Camb) 7(12): 1547-1560.
  15. Symonette, C.J., Kaur, Mann A., Tan, X.C., Tolg, C., Ma, J., Perera, F., Yazdani, A., Turley, E.A. (2014). Hyaluronan-Phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation.  BioMed Res Int.18(6)1-14. 
  16. Leong, H. S., Robertson, A. E., Stoletov, K., Leith, S. J., Chin, C. A., Chien, A. E., Hague, M. N., Ablack, A., Carmine-Simmen, K., McPherson, V. A., Postenka, C. O., Turley, E. A., Courtneidge, S. A., Chambers, A. F. and Lewis, J. D. (2014). Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. Cell Rep 8(5): 1558-1570.
  17. Tolg, C., McCarthy, J.B., Yazdani, A., Turley, E.A. (2014).  Hyaluronan and RHAMM:  Cancerization of the stroma.  Invited Review.  BioMed Res Int. 103923
  18. Veiseh, M., Kwon, D. H., Borowsky, A. D., Tolg, C., Leong, H. S., Lewis, J. D., Turley, E. A. and Bissell, M. J. (2014). Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A 111(17): E1731-1739.
  19. Rizzardi, A. E., Rosener, N. K., Koopmeiners, J. S., Isaksson Vogel, R., Metzger, G. J., Forster, C. L., Marston, L. O., Tiffany, J. R., McCarthy, J. B., Turley, E. A., Warlick, C. A., Henriksen, J. C. and Schmechel, S. C. (2014). Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer 14: 244.
  20. Rizzardi, A. E., Vogel, R. I., Koopmeiners, J. S., Forster, C. L., Marston, L. O., Rosener, N. K., Akentieva, N., Price, M. A., Metzger, G. J., Warlick, C. A., Henriksen, J. C., Turley, E. A., McCarthy, J. B. and Schmechel, S. C. (2014). Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors. Cancer 120(12): 1800-1809.
  21. Tolg, C., Telmer, P. and Turley, E. (2014). Specific sizes of hyaluronan oligosaccharides stimulate fibroblast migration and excisional wound repair. PLoS One 9(2): e88479.
  22. Ma, J., Granton, P.V., Holdsworth, D.W., Turley, E.A. (2013). Oral administration of hyaluronan reduces bone turnover in ovariectomized rats. J Agric Food Chem 61:339-45. 
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