Education
PhD, Cardiff University, UK, 1982
Current position
Distinguished Professor, Haskins Laboratories, Pace University, USA
Publications
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Bartulos, R. C., Rogers, M., Williams, T., Brinkmann, H., Cerff, R., Liaud, M. F., Hehl, A., Yarlett, N., Gruber, A., Kroth, P. and Giezen, M. (2018) Mitochondrial targeting of glycolysis in a major lineage of eukaryotes. Gen Biol Evol (in press).
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Morada, M., Lee, S., Gunther-Cummins, L., Weiss, L. M., Widmer, G., Tzipori, S. and Yarlett, N. (2016). Continuous culture of Cryptosporidium parvum using hollow fiber technology. Int J Parasitol 46(1): 21-29.
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Wring, S., Gaukel, E., Nare, B., Jacobs, R., Beaudet, B., Bowling, T., Mercer, L., Bacchi, C., Yarlett, N., Randolph, R., Parham, R., Rewerts, C., Platner, J. and Don, R. (2014). Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis. Parasitology 141(1): 104-118.
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Morada, M., Pendyala, L., Wu, G., Merali, S. and Yarlett, N. (2013). Cryptosporidium parvum induces an endoplasmic stress response in the intestinal adenocarcinoma HCT-8 cell line. J Biol Chem 288(42): 30356-30364.
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Yarlett, N. and Morada, M. (2012) Antiparasitic Drug Discovery for the Polyamine Pathway. In: Polyamine Drug Discovery. Patrick Woster & Robert Casero Jr. (eds). SC Drug Discovery Series No. 17. Royal Society of Chemistry pub.
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Jacobs, R. T., Plattner, J. J., Nare, B., Wring, S. A., Chen, D., Freund, Y., Gaukel, E. G., Orr, M. D., Perales, J. B., Jenks, M., Noe, R. A., Sligar, J. M., Zhang, Y. K., Bacchi, C. J., Yarlett, N. and Don, R. (2011). Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis. Future Med Chem 3(10): 1259-1278.
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Mercer, L., Bowling, T., Perales, J., Freeman, J., Nguyen, T., Bacchi, C., Yarlett, N., Don, R., Jacobs, R. and Nare, B. (2011). 2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. PLoS Negl Trop Dis 5(2): e956.
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Perales, J.B., Freeman, J., Bacchi, C. J., Bowling, T., Don, R., Gaukel, E., Mercer, L., Moore III, J.A., Nare, B., Nguyen, T. M., Noe, R. A., Randolph, R., Rewarts, C., Wring, S., Yarlett, N., Jacobs R. (2011) SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei. Bioorg Med Chem Letts. 21:2816-2819.
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Mayence, A., Vanden Eynde, J. J., Kaiser, M., Brun, R., Yarlett, N. and Huang, T. L. (2011). Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorg Med Chem 19(24): 7493-7500.
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Morada, M., Manzur, M., Lam, B., Tan, C., Tachezy, J., Rappelli, P., Dessi, D., Fiori, P. L. and Yarlett, N. (2010). Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis. Microbiology 156(Pt 12): 3734-3743.
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Nare, B., Wring, S., Bacchi, C., Beaudet, B., Bowling, T., Brun, R., Chen, D., Ding, C., Freund, Y., Gaukel, E., Hussain, A., Jarnagin, K., Jenks, M., Kaiser, M., Mercer, L., Mejia, E., Noe, A., Orr, M., Parham, R., Plattner, J., Randolph, R., Rattendi, D., Rewerts, C., Sligar, J., Yarlett, N., Don, R. and Jacobs, R. (2010). Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother 54(10): 4379-4388.
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Huang, T. L., Vanden Eynde, J. J., Mayence, A., Collins, M. S., Cushion, M. T., Rattendi, D., Londono, I., Mazumder, L., Bacchi, C. J. and Yarlett, N. (2009). Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorg Med Chem Lett 19(20): 5884-5886.
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Bacchi, C.J., Yarlett, N., Faciane, E., Bi, X., Rattendi, D., Weiss and Woster, P. (2009) Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimic Ag Chemother 53:2599-2604.
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Lantsmanm, Y., Tan, K. S. W., Morada, M. and Yarlett, N. (2008) Biochemical characterization of a mitochondrial-like organelle from Blastocystis sp. subtype 7. Microbiology 154:2757-2766.
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Yarlett, N., Wu, G., Waters, W. R., Harp, J. A., Wannemuehler, M. J., Morada, M., Athanasopoulos, D., Martinez, M. P., Upton, S. J., Marton, L. J. and Frydman, B. J. (2007). Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. Mol Biochem Parasitol 152(2): 170-180.
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Cook, T., Roos, D., Morada, M., Zhu, G., Keithly, J. S., Feagin, J. E., Wu, G. and Yarlett, N. (2007). Divergent polyamine metabolism in the Apicomplexa. Microbiology 153(Pt 4): 1123-1130.
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Yarlett N, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Bellcastro J, Upton SJ, Marton, L. J. and Frydman, B. J. (2007) Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha deficient mouse model. Antimic. Ag. Chemother 51:1234-1239.