Tomas Aparicio
  • Research scientist, Columbia University
Research fields
  • Molecular Biology
Personal information


PhD, 2010

Lab information


Research focus

DNA replication, DNA repair, DNA damage signaling, chromatin

Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning
TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S,
Gautier J, Madireddy A, A Ferrando A. Functional mapping of PHF6 complexes in
chromatin remodeling, replication dynamics, and DNA repair. Blood. 2022 Jun
9;139(23):3418-3429. doi: 10.1182/blood.2021014103. PMID: 35338774; PMCID:

Tao Y, Aparicio T, Li M, Leong KW, Zha S, Gautier J. Inhibition of DNA
replication initiation by silver nanoclusters. Nucleic Acids Res. 2021 May
21;49(9):5074-5083. doi: 10.1093/nar/gkab271. PMID: 33905520; PMCID: PMC8136792.

Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME,
Gautier J. Nuclear ARP2/3 drives DNA break clustering for homology-directed
repair. Nature. 2018 Jul;559(7712):61-66. doi: 10.1038/s41586-018-0237-5. Epub
2018 Jun 20. PMID: 29925947; PMCID: PMC6145447.

Aparicio T, Baer R, Gautier J. DNA double-strand break repair pathway choice
and cancer. DNA Repair (Amst). 2014 Jul;19:169-75. doi:
10.1016/j.dnarep.2014.03.014. Epub 2014 Apr 18. PMID: 24746645; PMCID:

Aparicio T, Gautier J. BRCA1-CtIP interaction in the repair of DNA double-
strand breaks. Mol Cell Oncol. 2016 Mar 30;3(4):e1169343. doi:
10.1080/23723556.2016.1169343. PMID: 27652321; PMCID: PMC4972120.

Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate
repair of topoisomerase II-DNA adducts. J Cell Biol. 2016 Feb 15;212(4):399-408.
doi: 10.1083/jcb.201504005. PMID: 26880199; PMCID: PMC4754713.

Aparicio T, Gautier J. More tasks for Dna2 in S-phase. Cell Cycle. 2012 Dec
1;11(23):4299-300. doi: 10.4161/cc.22807. Epub 2012 Nov 16. PMID: 23159855;
PMCID: PMC3552907.

Aparicio T, Megías D, Méndez J. Visualization of the MCM DNA helicase at
replication factories before the onset of DNA synthesis. Chromosoma. 2012
Oct;121(5):499-507. doi: 10.1007/s00412-012-0381-x. Epub 2012 Aug 22. PMID:

Aparicio T, Guillou E, Coloma J, Montoya G, Méndez J. The human GINS complex
associates with Cdc45 and MCM and is essential for DNA replication. Nucleic
Acids Res. 2009 Apr;37(7):2087-95. doi: 10.1093/nar/gkp065. Epub 2009 Feb 17.
PMID: 19223333; PMCID: PMC2673421.

Boskovic J, Coloma J, Aparicio T, Zhou M, Robinson CV, Méndez J, Montoya G.
Molecular architecture of the human GINS complex. EMBO Rep. 2007
Jul;8(7):678-84. doi: 10.1038/sj.embor.7401002. Epub 2007 Jun 8. PMID: 17557111;
PMCID: PMC1905900.

Aparicio T, Ibarra A, Méndez J. Cdc45-MCM-GINS, a new power player for DNA
replication. Cell Div. 2006 Aug 24;1:18. doi: 10.1186/1747-1028-1-18. PMID:
16930479; PMCID: PMC1564009.
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