Miranda Mele
  • CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, Portugal,
Research fields
  • Neuroscience
Personal information


PhD, University of Coimbra , Portugal, 2013

Current position

Post-Doc, Neuroscience and disease, Center for Neuroscience and Cell Biology of Coimbra, Portugal


  1. Mele, M., Leal, G. and Duarte, C. B. (2016). Role of GABAA R trafficking in the plasticity of inhibitory synapses. J Neurochem 139(6): 997-1018.
  2. Curcio, M., Salazar, I. L., Mele, M., Canzoniero, L. M. and Duarte, C. B. (2016). Calpains and neuronal damage in the ischemic brain: The swiss knife in synaptic injury. Prog Neurobiol 143: 1-35.
  3. Mele, M., Aspromonte, M. C. and Duarte, C. B. (2017). Downregulation of GABAA Receptor Recycling Mediated by HAP1 Contributes to Neuronal Death in In Vitro Brain Ischemia. Mol Neurobiol 54(1): 45-57.
  4. Vieira, M. M., Schmidt, J., Ferreira, J. S., She, K., Oku, S., Mele, M., Santos, A. E., Duarte, C. B., Craig, A. M. and Carvalho, A. L. (2016). Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia. Neurobiol Dis 89: 223-234.
  5. Costa, J. T., Mele, M., Baptista, M. S., Gomes, J. R., Ruscher, K., Nobre, R. J., de Almeida, L. P., Wieloch, T. and Duarte, C. B. (2016). Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death. Mol Neurobiol 53(6): 3513-3527.
  6. Santos, A. R., Mele, M., Vaz, S. H., Kellermayer, B., Grimaldi, M., Colino-Oliveira, M., Rombo, D. M., Comprido, D., Sebastiao, A. M. and Duarte, C. B. (2015). Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP. J Neurosci 35(8): 3319-3329.
  7. Mele, M., Ribeiro, L., Inacio, A. R., Wieloch, T. and Duarte, C. B. (2014). GABA(A) receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia. Neurobiol Dis 65: 220-232.
  8. Melo, C. V., Mele, M., Curcio, M., Comprido, D., Silva, C. G. and Duarte, C. B. (2013). BDNF regulates the expression and distribution of vesicular glutamate transporters in cultured hippocampal neurons. PLoS One 8(1): e53793.
  9. Caldeira, M. V., Curcio, M., Leal, G., Salazar, I. L., Mele, M., Santos, A. R., Melo, C. V., Pereira, P., Canzoniero, L. M. and Duarte, C. B. (2013). Excitotoxic stimulation downregulates the ubiquitin-proteasome system through activation of NMDA receptors in cultured hippocampal neurons. Biochim Biophys Acta 1832(1): 263-274.
  10. Lobo, A. C., Gomes, J. R., Catarino, T., Mele, M., Fernandez, P., Inacio, A. R., Bahr, B. A., Santos, A. E., Wieloch, T., Carvalho, A. L. and Duarte, C. B. (2011). Cleavage of the vesicular glutamate transporters under excitotoxic conditions. Neurobiol Dis 44(3): 292-303.
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