Heather McCauley Cincinnati Children's Hospital Medical Center
1 protocol

Geraldine Guasch
  • Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, USA, USA,
Research focus
  • Cancer biology
  • 1 Author merit


PhD, Aix-Marseille Universite, France, 2002

Current position

Associate Professor, Molecular Oncology, INSERM, France


  1. McCauley, H. A., Chevrier, V., Birnbaum, D. and Guasch, G. (2017). De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFbeta-deficient squamous cell carcinoma from transition zones. Elife 6.
  2. McCauley, H. A. and Guasch, G. (2015). Three cheers for the goblet cell: maintaining homeostasis in mucosal epithelia. Trends Mol Med 21(8): 492-503.
  3. McCauley, H. A., Liu, C. Y., Attia, A. C., Wikenheiser-Brokamp, K. A., Zhang, Y., Whitsett, J. A. and Guasch, G. (2014). TGFbeta signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development 141(23): 4628-4639.
  4. Gupta, A., Bischoff, A., Pena, A., Runck, L. A. and Guasch, G. (2014). The great divide: septation and malformation of the cloaca, and its implications for surgeons. Pediatr Surg Int 30(11): 1089-1095.
  5. Runck, L. A., Method, A., Bischoff, A., Levitt, M., Pena, A., Collins, M. H., Gupta, A., Shanmukhappa, S., Wells, J. M. and Guasch, G. (2014). Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech 7(4): 483-493.
  6. McCauley, H. A. and Guasch, G. (2013). Serial orthotopic transplantation of epithelial tumors in single-cell suspension. Methods Mol Biol 1035: 231-245.
  7. Chang, C. Y., Pasolli, H. A., Giannopoulou, E. G., Guasch, G., Gronostajski, R. M., Elemento, O. and Fuchs, E. (2013). NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature 495(7439): 98-102.
  8. McNairn, A. J., Doucet, Y., Demaude, J., Brusadelli, M., Gordon, C. B., Uribe-Rivera, A., Lambert, P. F., Bouez, C., Breton, L. and Guasch, G. (2013). TGFbeta signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol 13: 2.
  9. McNairn, A., Brusadelli, M. and Guasch, G. (2013). Signaling moderation: TGF-β in exocrine gland development, maintenance, and regulation. European Journal of Dermatology 23(Suppl.2): 31-38.
  10. McNairn, A. J. and Guasch, G. (2011). Epithelial transition zones: merging microenvironments, niches, and cellular transformation. Eur J Dermatol 21 Suppl 2: 21-28.
  11. Runck, L. A., Kramer, M., Ciraolo, G., Lewis, A. G. and Guasch, G. (2010). Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle 9(15): 3039-3045.
  12. Guasch, G., Schober, M., Pasolli, H. A., Conn, E. B., Polak, L. and Fuchs, E. (2007). Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12(4): 313-327.
  13. Li, J., Greco, V., Guasch, G., Fuchs, E. and Mombaert, P. (2007). Mice cloned from skin cells. Proc Natl Acad Sci USA 104: 2738-2743.
  14. Guasch, G. (2006). Epithelial stem cell of the skin. Medecine & Science 22(8-9): 710-712.
  15. Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L. and Fuchs, E. (2005). Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 19(13): 1596-1611.
  16. Guasch, G. and Fuchs, E. (2005). Mice in the world of stem cell biology. Nat Genet 37(11): 1201-1206.
  17. Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M. and Fuchs, E. (2004). Defining the epithelial stem cell niche in skin. Science 303(5656): 359-363.
  18. Fuchs, E., Tumbar, T. and Guasch, G. (2004). Socializing with the neighbors: stem cells and their niche. Cell 116(6): 769-778.
  19. Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M. and Fuchs, E. (2004). Defining the epithelial stem cell niche in skin. Science 303(5656): 359-363.
  20. Guasch, G., Delaval, B., Arnoulet, C., Xie, M. J., Xerri, L., Sainty, D., Birnbaum, D. and Pebusque, M. J. (2004). FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Blood 103(1): 309-312.
  21. Suzan, F., Guasch, G., Terre, C., Garcia, I., Bastie, J. N., Maarek, O., Ribaud, P., Gluckman, E., Daniel, M. T., Pébusque, M. J. and Castaigne, S. (2003). Long-term complete hematological and molecular remission after allogeneic bone marrow transplantation in a patient with a stem cell myeloproliferative disorder associated with t(8;13)(p12;q12). British J of Haematol 121: 312-314.
  22. Guasch, G., Popovici, C., Mugneret, F., Chaffanet, M., Pontarotti, P., Birnbaum, D. and Pebusque, M. J. (2003). Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood 101(1): 286-288.
  23. Guasch, G., Birnbaum, D. and Pébusque, M. J. (2003). A distinct clinical entity of myeloproliferative disorders: the 8p12 myeloproliferative syndrome associated with FGFR1. Hématologie 9: 43-57.
  24. Guasch, G., Ollendorff, V., Borg, J. P., Birnbaum, D. and Pebusque, M. J. (2001). 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways. Mol Cell Biol 21(23): 8129-8142.
  25. Mugneret, F., Chaffanet, M., Maynadie, M., Guasch, G., Favre, B., Casasnovas, O., Birnbaum, D. and Pebusque, M. J. (2000). The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene. Br J Haematol 111(2): 647-649.
  26. Guasch, G., Mack, G. J., Popovici, C., Dastugue, N., Birnbaum, D., Rattner, J. B. and Pebusque, M. J. (2000). FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood 95(5): 1788-1796.
  27. Ollendorff, V., Guasch, G., Isnardon, D., Galindo, R., Birnbaum, D. and Pebusque, M. J. (1999). Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation. J Biol Chem 274(38): 26922-26930.
  28. Popovici, C., Adelaide, J., Ollendorff, V., Chaffanet, M., Guasch, G., Jacrot, M., Leroux, D., Birnbaum, D. and Pebusque, M. J. (1998). Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Proc Natl Acad Sci U S A 95(10): 5712-5717.
1 Protocol published
Isolation and Separation of Epithelial CD34+ Cancer Stem Cells from Tgfbr2-deficient Squamous Cell Carcinoma
Authors:  Heather A. McCauley and Géraldine Guasch, date: 09/05/2017, view: 8341, Q&A: 0
Most epithelial tumors have been shown to contain cancer stem cells that are potentially the driving force in tumor progression and metastasis (Kreso and Dick, 2014; Nassar and Blanpain, 2016). To study these cells in depth, cell isolation ...
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