Ulrich Thomas Leibniz Institute for Neurobiology, Germany
2 protocols

Julia Abele Otto-von-Guericke University, Germany
2 protocols

Anke Müller Otto-von-Guericke University, Germany
2 protocols

Peter Landgraf 1 protocol

Daniela C. Dieterich
  • Institute for Pharmacology and Toxicology, Otto-von-Guericke University, Germany
Research focus
  • Biochemistry
  • 2 Author merit


Ph.D (Dr. rer. nat.) in Neurobiology, Leibniz Institute for Neurobiology, Otto-von-Guericke University Magdeburg, Germany, 2003

Current position

Professor, Institute for Pahrmacology and Toxicology, Otto-von-Guericke University Magdeburg, Germany


  1. Fernandez-Orth, J., Ehling, P., Ruck, T., Pankratz, S., Hofmann, M. S., Landgraf, P., Dieterich, D. C., Smalla, K. H., Kahne, T., Seebohm, G., Budde, T., Wiendl, H., Bittner, S. and Meuth, S. G. (2017). 14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes. Traffic 18(1): 29-43.
  2. Moradi, M., Sivadasan, R., Saal, L., Luningschror, P., Dombert, B., Rathod, R. J., Dieterich, D. C., Blum, R. and Sendtner, M. (2017). Differential roles of alpha-, beta-, and gamma-actin in axon growth and collateral branch formation in motoneurons. J Cell Biol 216(3): 793-814.
  3. Dieterich, D. C. and Kreutz, M. R. (2016). Proteomics of the Synapse--A Quantitative Approach to Neuronal Plasticity. Mol Cell Proteomics 15(2): 368-381.
  4. Rosenberg, T., Elkobi, A., Dieterich, D. C. and Rosenblum, K. (2016). NMDAR-dependent proteasome activity in the gustatory cortex is necessary for conditioned taste aversion. Neurobiol Learn Mem 130: 7-16.
  5. Jalsrai, A., Numakawa, T., Kunugi, H., Dieterich, D. C. and Becker, A. (2016). The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies. Neuroscience 322: 452-463.
  6. Kahne, T., Richter, S., Kolodziej, A., Smalla, K. H., Pielot, R., Engler, A., Ohl, F. W., Dieterich, D. C., Seidenbecher, C., Tischmeyer, W., Naumann, M. and Gundelfinger, E. D. (2016). Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. J Neurochem 138(1): 124-138.
  7. Kolodziej, A., Smalla, K. H., Richter, S., Engler, A., Pielot, R., Dieterich, D. C., Tischmeyer, W., Naumann, M. and Kahne, T. (2016). High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning. J Vis Exp(118).
  8. Buchborn, T., Schroder, H., Dieterich, D. C., Grecksch, G. and Hollt, V. (2015). Tolerance to LSD and DOB induced shaking behaviour: differential adaptations of frontocortical 5-HT(2A) and glutamate receptor binding sites. Behav Brain Res 281: 62-68.
  9. Erdmann, I., Marter, K., Kobler, O., Niehues, S., Abele, J., Muller, A., Bussmann, J., Storkebaum, E., Ziv, T., Thomas, U. and Dieterich, D. C. (2015). Cell-selective labelling of proteomes in Drosophila melanogaster. Nat Commun 6: 7521.
  10. Landgraf, P., Antileo, E. R., Schuman, E. M. and Dieterich, D. C. (2015). BONCAT: metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes. Methods Mol Biol 1266: 199-215.
  11. Muller, A., Stellmacher, A., Freitag, C. E., Landgraf, P. and Dieterich, D. C. (2015). Monitoring Astrocytic Proteome Dynamics by Cell Type-Specific Protein Labeling. PLoS One 10(12): e0145451.
  12. Niehues, S., Bussmann, J., Steffes, G., Erdmann, I., Kohrer, C., Sun, L., Wagner, M., Schafer, K., Wang, G., Koerdt, S. N., Stum, M., Jaiswal, S., RajBhandary, U. L., Thomas, U., Aberle, H., Burgess, R. W., Yang, X. L., Dieterich, D. and Storkebaum, E. (2015). Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nat Commun 6: 7520.
  13. Reichenbach, N., Herrmann, U., Kahne, T., Schicknick, H., Pielot, R., Naumann, M., Dieterich, D. C., Gundelfinger, E. D., Smalla, K. H. and Tischmeyer, W. (2015). Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. Proteome Sci 13: 13.
  14. Fu, T., Stellmacher, A., Znalesniak, E. B., Dieterich, D. C., Kalbacher, H. and Hoffmann, W. (2014). Tff3 is expressed in neurons and microglial cells. Cell Physiol Biochem 34(6): 1912-1919.
  15. Rosenberg, T., Gal-Ben-Ari, S., Dieterich, D. C., Kreutz, M. R., Ziv, N. E., Gundelfinger, E. D. and Rosenblum, K. (2014). The roles of protein expression in synaptic plasticity and memory consolidation. Front Mol Neurosci 7: 86.
  16. Cohen, L. D., Zuchman, R., Sorokina, O., Muller, A., Dieterich, D. C., Armstrong, J. D., Ziv, T. and Ziv, N. E. (2013). Metabolic turnover of synaptic proteins: kinetics, interdependencies and implications for synaptic maintenance. PLoS One 8(5): e63191.
  17. Hinz, F. I., Dieterich, D. C. and Schuman, E. M. (2013). Teaching old NCATs new tricks: using non-canonical amino acid tagging to study neuronal plasticity. Curr Opin Chem Biol 17(5): 738-746.
  18. Howden, A. J., Geoghegan, V., Katsch, K., Efstathiou, G., Bhushan, B., Boutureira, O., Thomas, B., Trudgian, D. C., Kessler, B. M., Dieterich, D. C., Davis, B. G. and Acuto, O. (2013). QuaNCAT: quantitating proteome dynamics in primary cells. Nat Methods 10(4): 343-346.
  19. Hinz, F. I., Dieterich, D. C., Tirrell, D. A. and Schuman, E. M. (2012). Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish. ACS Chem Neurosci 3(1): 40-49.
  20. Hodas, J. J., Nehring, A., Hoche, N., Sweredoski, M. J., Pielot, R., Hess, S., Tirrell, D. A., Dieterich, D. C. and Schuman, E. M. (2012). Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics 12(15-16): 2464-2476.
  21. Pielot, R., Smalla, K. H., Muller, A., Landgraf, P., Lehmann, A. C., Eisenschmidt, E., Haus, U. U., Weismantel, R., Gundelfinger, E. D. and Dieterich, D. C. (2012). SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations. Front Synaptic Neurosci 4: 1.
  22. Tom Dieck, S., Muller, A., Nehring, A., Hinz, F. I., Bartnik, I., Schuman, E. M. and Dieterich, D. C. (2012). Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging. Curr Protoc Cell Biol Chapter 7: Unit7 11.
  23. Dieterich, D. C. (2010). Chemical reporters for the illumination of protein and cell dynamics. Curr Opin Neurobiol 20(5): 623-630.
  24. Szychowski, J., Mahdavi, A., Hodas, J. J., Bagert, J. D., Ngo, J. T., Landgraf, P., Dieterich, D. C., Schuman, E. M. and Tirrell, D. A. (2010). Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition. J Am Chem Soc 132(51): 18351-18360.
  25. Dieterich, D. C., Hodas, J. J., Gouzer, G., Shadrin, I. Y., Ngo, J. T., Triller, A., Tirrell, D. A. and Schuman, E. M. (2010). In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nat Neurosci 13(7): 897-905.
  26. Taylor, A. M., Dieterich, D. C., Ito, H. T., Kim, S. A. and Schuman, E. M. (2010). Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron 66(1): 57-68.
  27. Kindler, S., Dieterich, D. C., Schutt, J., Sahin, J., Karpova, A., Mikhaylova, M., Schob, C., Gundelfinger, E. D., Kreienkamp, H. J. and Kreutz, M. R. (2009). Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis. J Biol Chem 284(37): 25431-25440.
  28. Ngo, J. T., Champion, J. A., Mahdavi, A., Tanrikulu, I. C., Beatty, K. E., Connor, R. E., Yoo, T. H., Dieterich, D. C., Schuman, E. M. and Tirrell, D. A. (2009). Cell-selective metabolic labeling of proteins. Nat Chem Biol 5(10): 715-717.
  29. Dieterich, D. C., Karpova, A., Mikhaylova, M., Zdobnova, I., Konig, I., Landwehr, M., Kreutz, M., Smalla, K. H., Richter, K., Landgraf, P., Reissner, C., Boeckers, T. M., Zuschratter, W., Spilker, C., Seidenbecher, C. I., Garner, C. C., Gundelfinger, E. D. and Kreutz, M. R. (2008). Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biol 6(2): e34.
  30. Dieterich, D. C., Lee, J. J., Link, A. J., Graumann, J., Tirrell, D. A. and Schuman, E. M. (2007). Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging. Nat Protoc 2(3): 532-540.
  31. Beatty, K. E., Liu, J. C., Xie, F., Dieterich, D. C., Schuman, E. M., Wang, Q. and Tirrell, D. A. (2006). Fluorescence visualization of newly synthesized proteins in mammalian cells. Angew Chem Int Ed Engl 45(44): 7364-7367.
  32. Dieterich, D. C., Link, A. J., Graumann, J., Tirrell, D. A. and Schuman, E. M. (2006). Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT). Proc Natl Acad Sci U S A 103(25): 9482-9487.
  33. Kreutz, M. R., Weise, J., Dieterich, D. C., Kreutz, M., Balczarek, P., Bockers, T. M., Wittkowski, W., Gundelfinger, E. D. and Sabel, B. A. (2004). Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat. Eur J Neurosci 19(2): 247-257.
  34. Seidenbecher, C. I., Landwehr, M., Smalla, K. H., Kreutz, M., Dieterich, D. C., Zuschratter, W., Reissner, C., Hammarback, J. A., Bockers, T. M., Gundelfinger, E. D. and Kreutz, M. R. (2004). Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins. J Mol Biol 336(4): 957-970.
  35. Dieterich, D. C., Landwehr, M., Reissner, C., Smalla, K. H., Richter, K., Wolf, G., Bockers, T. M., Gundelfinger, E. D. and Kreutz, M. R. (2003). Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes. J Neurochem 85(5): 1117-1125.
  36. Landwehr, M., Redecker, P., Dieterich, D. C., Richter, K., Bockers, T. M., Gundelfinger, E. D. and Kreutz, M. R. (2003). Association of Caldendrin splice isoforms with secretory vesicles in neurohypophyseal axons and the pituitary. FEBS Lett 547(1-3): 189-192.
  37. Dieterich, D. C., Bockers, T. M., Gundelfinger, E. D. and Kreutz, M. R. (2002). Screening for differentially expressed genes in the rat inner retina and optic nerve after optic nerve crush. Neurosci Lett 317(1): 29-32.
  38. Dieterich, D. C., Trivedi, N., Engelmann, R., Gundelfinger, E. D., Gordon-Weeks, P. R. and Kreutz, M. R. (2002). Partial regeneration and long-term survival of rat retinal ganglion cells after optic nerve crush is accompanied by altered expression, phosphorylation and distribution of cytoskeletal proteins. Eur J Neurosci 15(9): 1433-1443.
  39. Laube, G., Seidenbecher, C. I., Richter, K., Dieterich, D. C., Hoffmann, B., Landwehr, M., Smalla, K. H., Winter, C., Bockers, T. M., Wolf, G., Gundelfinger, E. D. and Kreutz, M. R. (2002). The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system. Mol Cell Neurosci 19(3): 459-475.
  40. Engelmann, R., Dieterich, D. C., Bien, A. and Kreutz, M. R. (2001). A different retinal glia response to optic nerve injury/lipopolysaccharide administration in hooded and albino rats. Brain Res 889(1-2): 251-255.
  41. Kreutz, M. R., Langnaese, K., Dieterich, D. C., Seidenbecher, C. I., Zuschratter, W., Beesley, P. W. and Gundelfinger, E. D. (2001). Distribution of transcript and protein isoforms of the synaptic glycoprotein neuroplastin in rat retina. Invest Ophthalmol Vis Sci 42(8): 1907-1914.
2 Protocols published
Click Chemistry (CuAAC) and Detection of Tagged de novo Synthesized Proteins in Drosophila
Copper-catalyzed azide-alkyne-cycloaddition (CuAAC), also known as ‘click chemistry’ serves as a technique for bio-orthogonal, that is, bio-compatible labeling of macromolecules including proteins or lipids. Click chemistry has been widely used to ...
Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila
Advanced mass spectrometry technology has pushed proteomic analyses to the forefront of biological and biomedical research. Limitations of proteomic approaches now often remain with sample preparations rather than with the sensitivity of protein ...
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