Anne Ephrussi
  • Developmental Biology Unit, European Molecular Biology Laboratory (EMBL), Germany
Research fields
  • Developmental biology
Personal information


Ph.D, Massachusetts Institute of Technology, USA, 1985

Current position

PI, Developmental Biology Unit, European Molecular BIology Laboratory, Germany

Publications (since 2005)

  1. Jeske, M., Müller, C. W. and Ephrussi, A. (2017). The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Genes and Development 31: 1-13.
  2. Gaspar, I., Sysoev, V., Komissarov, A. and Ephrussi, A. (2017). An RNA-binding atypical tropomyosin recruits kinesin-1 dynamically to oskar mRNPs. EMBO J 36(3): 319-333.
  3. Sysoev, V. O., Fischer, B., Frese, C. K., Gupta, I., Krijgsveld, J., Hentze, M. W., Castello, A. and Ephrussi, A. (2016). Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila. Nat Commun 7: 12128.
  4. Halstead, J. M., Wilbertz, J. H., Wippich, F., Lionnet, T., Ephrussi, A. and Chao, J. A. (2016). TRICK: A Single-Molecule Method for Imaging the First Round of Translation in Living Cells and Animals. Methods Enzymol 572: 123-157.
  5. Sampath, K. and Ephrussi, A. (2016). CncRNAs: RNAs with both coding and non-coding roles in development. Development 143(8): 1234-1241.
  6. Jeske, M., Bordi, M., Glatt, S., Muller, S., Rybin, V., Muller, C. W. and Ephrussi, A. (2015). The Crystal Structure of the Drosophila Germline Inducer Oskar Identifies Two Domains with Distinct Vasa Helicase- and RNA-Binding Activities. Cell Rep 12(4): 587-598.
  7. Simon, B., Masiewicz, P., Ephrussi, A. and Carlomagno, T. (2015). The structure of the SOLE element of oskar mRNA. RNA 21(8): 1444-1453.
  8. Kanke, M., Jambor, H., Reich, J., Marches, B., Gstir, R., Ryu, Y. H., Ephrussi, A. and Macdonald, P. M. (2015). oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction. RNA 21(6): 1096-1109.
  9. Halstead, J. M., Lionnet, T., Wilbertz, J. H., Wippich, F., Ephrussi, A., Singer, R. H. and Chao, J. A. (2015). Translation. An RNA biosensor for imaging the first round of translation from single cells to living animals. Science 347(6228): 1367-1671.
  10. Medioni, C., Ephrussi, A. and Besse, F. (2015). Live imaging of axonal transport in Drosophila pupal brain explants. Nat Protoc 10(4): 574-584.
  11. Gaspar, I. and Ephrussi, A. (2015). Strength in numbers: quantitative single-molecule RNA detection assays. Wiley Interdiscip Rev Dev Biol 4(2): 135-150.
  12. Hovelmann, F., Gaspar, I., Loibl, S., Ermilov, E. A., Roder, B., Wengel, J., Ephrussi, A. and Seitz, O. (2014). Brightness through local constraint--LNA-enhanced FIT hybridization probes for in vivo ribonucleotide particle tracking. Angew Chem Int Ed Engl 53(42): 11370-11375.
  13. Bassett, A. R., Akhtar, A., Barlow, D. P., Bird, A. P., Brockdorff, N., Duboule, D., Ephrussi, A., Ferguson-Smith, A. C., Gingeras, T. R., Haerty, W., Higgs, D. R., Miska, E. A. and Ponting, C. P. (2014). Considerations when investigating lncRNA function in vivo. Elife 3: e03058.
  14. Gaspar, I., Yu, Y. V., Cotton, S. L., Kim, D. H., Ephrussi, A. and Welte, M. A. (2014). Klar ensures thermal robustness of oskar localization by restraining RNP motility. J Cell Biol 206(2): 199-215.
  15. Xiol, J., Spinelli, P., Laussmann, M. A., Homolka, D., Yang, Z., Cora, E., Coute, Y., Conn, S., Kadlec, J., Sachidanandam, R., Kaksonen, M., Cusack, S., Ephrussi, A. and Pillai, R. S. (2014). RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts. Cell 157(7): 1698-1711.
  16. Ghosh, S., Obrdlik, A., Marchand, V. and Ephrussi, A. (2014). The EJC binding and dissociating activity of PYM is regulated in Drosophila. PLoS Genet 10(6): e1004455.
  17. Medioni, C., Ramialison, M., Ephrussi, A. and Besse, F. (2014). Imp promotes axonal remodeling by regulating profilin mRNA during brain development. Curr Biol 24(7): 793-800.
  18. Jambor, H., Mueller, S., Bullock, S. L. and Ephrussi, A. (2014). A stem-loop structure directs oskar mRNA to microtubule minus ends. RNA 20(4): 429-439.
  19. Hovelmann, F., Gaspar, I., Ephrussi, A. and Seitz, O. (2013). Brightness enhanced DNA FIT-probes for wash-free RNA imaging in tissue. J Am Chem Soc 135(50): 19025-19032.
  20. Telley, I. A., Gaspar, I., Ephrussi, A. and Surrey, T. (2013). A single Drosophila embryo extract for the study of mitosis ex vivo. Nat Protoc 8(2): 310-324.
  21. Leibfried, A., Muller, S. and Ephrussi, A. (2013). A Cdc42-regulated actin cytoskeleton mediates Drosophila oocyte polarization. Development 140(2): 362-371.
  22. Telley, I. A., Gaspar, I., Ephrussi, A. and Surrey, T. (2012). Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo. J Cell Biol 197(7): 887-895.
  23. Ghosh, S., Marchand, V., Gaspar, I. and Ephrussi, A. (2012). Control of RNP motility and localization by a splicing-dependent structure in oskar mRNA. Nat Struct Mol Biol 19(4): 441-449.
  24. Marchand, V., Gaspar, I. and Ephrussi, A. (2012). An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes. Curr Opin Cell Biol 24(2): 202-210.
  25. Jambor, H., Brunel, C. and Ephrussi, A. (2011). Dimerization of oskar 3' UTRs promote hitchhiking for RNA localization in the Drosophila oocyte. RNA 17: 2049-57.
  26. Fan, S. J., Marchand, V. and Ephrussi, A. (2011). Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS One 6(5): e20612.
  27. Krauss, J., Lopez de Quinto, S., Nusslein-Volhard, C. and Ephrussi, A. (2009). Myosin-V regulates oskar mRNA localization in the Drosophila oocyte. Curr Biol 19(12): 1058-1063.
  28. Martin, K. C. and Ephrussi, A. (2009). mRNA localization: gene expression in the spatial dimension. Cell 136(4): 719-730.
  29. Besse, F., Lopez de Quinto, S., Marchand, V., Trucco, A. and Ephrussi, A. (2009). Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation. Genes Dev 23(2): 195-207.
  30. Suyama, R., Jenny, A., Curado, S., Pellis-van Berkel, W. and Ephrussi, A. (2009). The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo. Development 136(1): 95-105.
  31. Besse, F. and Ephrussi, A. (2008). Translational control of localized mRNAs: restricting protein synthesis in space and time. Nat Rev Mol Cell Biol 9(12): 971-980.
  32. Sung, H. H., Telley, I. A., Papadaki, P., Ephrussi, A., Surrey, T. and Rorth, P. (2008). Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. Dev Cell 15(6): 866-876.
  33. Besse F., Mertel S., Kittel R.J., Wichmann, C., Rasse T.M., Sigrist S.J., and Ephrussi A. (2007). The Ig CAM Basigin controls compartmentalization and vesicle release at Drosophila synapses. Journal of Cell Biology 177: 843-855.
  34. Vanzo, N., Oprins, A., Xanthakis, D., Ephrussi, A. and Rabouille, C. (2007). Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Dev Cell 12(4): 543-555.
  35. Coutelis, J. B. and Ephrussi, A. (2007). Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis. Development 134(7): 1419-1430.
  36. Anne, J., Ollo, R., Ephrussi, A. and Mechler, B. M. (2007). Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Development 134(1): 137-146.
  37. Jenny, A., Hachet, O., Zavorszky, P., Cyrklaff, A., Weston, M. D., Johnston, D. S., Erdelyi, M. and Ephrussi, A. (2006). A translation-independent role of oskar RNA in early Drosophila oogenesis. Development 133(15): 2827-2833.
  38. Chekulaeva, M., Hentze, M. W. and Ephrussi, A. (2006). Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell 124(3): 521-533.
  39. Staudt, N., Molitor, A., Somogyi, K., Mata, J., Curado, S., Eulenberg, K., Meise, M., Siegmund, T., Hader, T., Hilfiker, A., Bronner, G., Ephrussi, A., Rørth, P., Cohen, S.M., Fellert, S., Chung, H. R., Piepenburg, O., Schafer, U., Jackle, H. and Vorbruggen, G. (2005). Gain-of-function screen for genes that affect Drosophila muscle pattern formation. PLoS Genetics 1(4): e55.
  40. Vaccari, T., Rabouille, C. and Ephrussi, A. (2005). The Drosophila PAR-1 spacer domain is required for lateral membrane association and for polarization of follicular epithelial cells. Curr Biol 15(3): 255-261.
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