Chengbiao Wu
  • Department of Neurosciences, University of California San Diego, School of Medicine, USA
Research fields
  • Neuroscience
Personal information


Ph.D in Biology, Department of Biology, Queen’s University, Ontario, Canada, 1994

Current position

Associate Professor, Department of Neurosciences, University of California San Diego, La Jolla, CA

Publications (since 2001)

  1. Plotkin, J. L. and Wu, C. (2017). Neurotrophin biology at NGF 2016: From fundamental science to clinical applications. Int J Dev Neurosci 56: 27-34.
  2. Liu, H. and Wu, C. (2017). Charcot Marie Tooth 2B Peripheral Sensory Neuropathy: How Rab7 Mutations Impact NGF Signaling? Int J Mol Sci 18(2).
  3. Bett, C., Lawrence, J., Kurt, T. D., Orru, C., Aguilar-Calvo, P., Kincaid, A. E., Surewicz, W. K., Caughey, B., Wu, C. and Sigurdson, C. J. (2017). Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun 5(1): 32.
  4. Zhao, X., Chen, X. Q., Han, E., Hu, Y., Paik, P., Ding, Z., Overman, J., Lau, A. L., Shahmoradian, S. H., Chiu, W., Thompson, L. M., Wu, C. and Mobley, W. C. (2016). TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A 113(38): E5655-5664.
  5. Xu, W., Weissmiller, A. M., White, J. A., 2nd, Fang, F., Wang, X., Wu, Y., Pearn, M. L., Zhao, X., Sawa, M., Chen, S., Gunawardena, S., Ding, J., Mobley, W. C. and Wu, C. (2016). Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest 126(5): 1815-1833.
  6. Spencer, B., Desplats, P. A., Overk, C. R., Valera-Martin, E., Rissman, R. A., Wu, C., Mante, M., Adame, A., Florio, J., Rockenstein, E. and Masliah, E. (2016). Reducing Endogenous alpha-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci 36(30): 7971-7984.
  7. Le, M. H., Weissmiller, A. M., Monte, L., Lin, P. H., Hexom, T. C., Natera, O., Wu, C. and Rissman, R. A. (2016). Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One 11(1): e0147250.
  8. Zhao, Y., Tseng, I. C., Heyser, C. J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, P. E., Chakrabarty, P., Wu, C., Bu, G., Mobley, W. C., Zhang, Y. W., St George-Hyslop, P., Masliah, E., Fraser, P. and Xu, H. (2015). Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron 87(5): 963-975.
  9. Weissmiller, A. M., Natera-Naranjo, O., Reyna, S. M., Pearn, M. L., Zhao, X., Nguyen, P., Cheng, S., Goldstein, L. S., Tanzi, R. E., Wagner, S. L., Mobley, W. C. and Wu, C. (2015). A gamma-secretase inhibitor, but not a gamma-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One 10(2): e0118379.
  10. Zhao, X., Zhou, Y., Weissmiller, A. M., Pearn, M. L., Mobley, W. C. and Wu, C. (2014). Real-time imaging of axonal transport of quantum dot-labeled BDNF in primary neurons. J Vis Exp (91): 51899.
  11. Shahmoradian, S. H., Galiano, M. R., Wu, C., Chen, S., Rasband, M. N., Mobley, W. C. and Chiu, W. (2014). Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp (84): e50783.
  12. Ding, Z., German, P., Bai, S., Reddy, A. S., Liu, X. D., Sun, M., Zhou, L., Chen, X., Zhao, X., Wu, C., Zhang, S., Mills, G. B. and Jonasch, E. (2014). Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res 74(11): 3127-3136.
  13. Zhang, K., Fishel Ben Kenan, R., Osakada, Y., Xu, W., Sinit, R. S., Chen, L., Zhao, X., Chen, J. Y., Cui, B. and Wu, C. (2013). Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling. J Neurosci 33(17): 7451-7462.
  14. Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L. S., Cai, L., Thompson, R. C., Yang, B., Chen, Y., Johnson, P. F., Wu, C., Bu, G., Mobley, W. C., Zhang, D., Gage, F. H., Ranscht, B., Zhang, Y. W., Lipton, S. A., Hong, W. and Xu, H. (2013). Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med 19(4): 473-480.
  15. Weissmiller, A. M. and Wu, C. (2012). Current advances in using neurotrophic factors to treat neurodegenerative disorders. Transl Neurodegener 1(1): 14.
  16. Fjorback, A. W., Seaman, M., Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., Willnow, T. E., Christensen, E. I., Mobley, W. B., Nykjaer, A. and Andersen, O. M. (2012). Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci 32(4): 1467-1480.
  17. Chen, X. Q., Wang, B., Wu, C., Pan, J., Yuan, B., Su, Y. Y., Jiang, X. Y., Zhang, X. and Bao, L. (2012). Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res 22(4): 677-696.
  18. Chen, L., Holman, H. Y., Hao, Z., Bechtel, H. A., Martin, M. C., Wu, C. and Chu, S. (2012). Synchrotron infrared measurements of protein phosphorylation in living single PC12 cells during neuronal differentiation. Anal Chem 84(9): 4118-4125.
  19. Sung, K., Maloney, M. T., Yang, J. and Wu, C. (2011). A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transport. J Neurosci Methods 200(2): 121-128.
  20. Wu, C., Cui, B., He, L., Chen, L. and Mobley, W. C. (2009). The coming of age of axonal neurotrophin signaling endosomes. J Proteomics 72(1): 46-55.
  21. Belichenko, P. V., Kleschevnikov, A. M., Masliah, E., Wu, C., Takimoto-Kimura, R., Salehi, A. and Mobley, W. C. (2009). Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol 512(4): 453-466.
  22. Wan, J., Cheung, A. Y., Fu, W. Y., Wu, C., Zhang, M., Mobley, W. C., Cheung, Z. H. and Ip, N. Y. (2008). Endophilin B1 as a novel regulator of nerve growth factor/ TrkA trafficking and neurite outgrowth. J Neurosci 28(36): 9002-9012.
  23. Wu, C., Ramirez, A., Cui, B., Ding, J., Delcroix, J. D., Valletta, J. S., Liu, J. J., Yang, Y., Chu, S. and Mobley, W. C. (2007). A functional dynein-microtubule network is required for NGF signaling through the Rap1/MAPK pathway. Traffic 8(11): 1503-20.
  24. Liu, J. J., Ding, J., Wu, C., Bhagavatula, P., Cui, B., Chu, S., Mobley, W. C. and Yang, Y. (2007). Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A 104(7): 2223-2228.
  25. Cui, B., Wu, C., Chen, L., Ramirez, A., Bearer, E. L., Li, W. P., Mobley, W. C. and Chu, S. (2007). One at a time, live tracking of NGF axonal transport using quantum dots. Proc Natl Acad Sci U S A 104(34): 13666-13671.
  26. Salehi, A., Delcroix, J. D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., Xia, W., Villar, A., Campbell, W. A., Kulnane, L. S., Nixon, R. A., Lamb, B. T., Epstein, C. J., Stokin, G. B., Goldstein, L. S. and Mobley, W. C. (2006). Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 51(1): 29-42.
  27. Miyamoto, Y., Yamauchi, J., Tanoue, A., Wu, C. and Mobley, W. C. (2006). TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A 103(27): 10444-10449.
  28. Ding, J., Allen, E., Wang, W., Valle, A., Wu, C., Nardine, T., Cui, B., Yi, J., Taylor, A., Jeon, N. L., Chu, S., So, Y., Vogel, H., Tolwani, R., Mobley, W. and Yang, Y. (2006). Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. Hum Mol Genet 15(9): 1451-1463.
  29. Delcroix, J. D., Valletta, J., Wu, C., Howe, C. L., Lai, C. F., Cooper, J. D., Belichenko, P. V., Salehi, A. and Mobley, W. C. (2004). Trafficking the NGF signal: implications for normal and degenerating neurons. Prog Brain Res 146: 3-23.
  30. Liu, J. J., Ding, J., Kowal, A. S., Nardine, T., Allen, E., Delcroix, J. D., Wu, C., Mobley, W., Fuchs, E. and Yang, Y. (2003). BPAG1n4 is essential for retrograde axonal transport in sensory neurons. J Cell Biol 163(2): 223-229.
  31. Delcroix, J. D., Valletta, J. S., Wu, C., Hunt, S. J., Kowal, A. S. and Mobley, W. C. (2003). NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39(1): 69-84.
  32. Wu, C., Lai, C. F. and Mobley, W. C. (2001). Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci 21(15): 5406-5416.
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