Jiasong Guo
  • Department of Histology and Embryology, Southern Medical University, China
Research fields
  • Neuroscience
Personal information


Ph.D., Sun Yat-sen University, China, 2003

Current position

Professor, Histology &Embryology, Southern Medical University, China


  1. Pan, M., Wang, X., Chen, Y., Cao, S., Wen, J., Wu, G., Li, Y., Li, L., Qian, C., Qin, Z., Li, Z., Tan, D., Fan, Z., Wu, W. and Guo, J. (2017). Tissue engineering with peripheral blood-derived mesenchymal stem cells promotes the regeneration of injured peripheral nerves. Exp Neurol 292: 92-101.
  2. Wen, J., Qian, C., Pan, M., Wang, X., Li, Y., Lu, Y., Zhou, Z., Yan, Q., Li, L., Liu, Z., Wu, W. and Guo, J. (2017). Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells. Mol Neurobiol 54(2): 1229-1239.
  3. Wu, G., Pan, M., Wang, X., Wen, J., Cao, S., Li, Z., Li, Y., Qian, C., Liu, Z., Wu, W., Zhu, L. and Guo, J. (2015). Osteogenesis of peripheral blood mesenchymal stem cells in self assembling peptide nanofiber for healing critical size calvarial bony defect. Sci Rep 5: 16681.
  4. Qin, Z., Zheng, H., Zhou, L., Ou, Y., Huang, B., Yan, B., Qin, Z., Yang, C., Su, Y., Bai, X., Guo, J. and Lin, J. (2016). Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERalpha, and cell-cycle-driving proteins. Sci Rep 6: 19587.
  5. Qian, C. H., Wen, J. K. and Guo, J. S. (2015). Inhibiting the RhoA signaling pathway promotes regeneration of axons and myelin sheath. Neural Regen Res 10(12): 1957.
  6. Wang, X. H., Guo, J. S. (2015). Significance and strategy of promoting seed cell survival in tissue-engineered artificial nerve construction. Neural Regen Res 10(11): 1795.
  7. Guo, J., Wang, L., Zhang, Y., Wu, J., Arpag, S., Hu, B., Imhof, B. A., Tian, X., Carter, B. D., Suter, U. and Li, J. (2014). Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Ann Neurol 75(2): 255-265.
  8. Guo, J. S., Qian, C. H., Ling, E. A. and Zeng, Y. S. (2014). Nanofiber scaffolds for treatment of spinal cord injury. Curr Med Chem 21(37): 4282-4289.
  9. Wang, X., Pan, M., Wen, J., Tang, Y., Hamilton, A. D., Li, Y., Qian, C., Liu, Z., Wu, W. and Guo, J. (2014). A novel artificial nerve graft for repairing long-distance sciatic nerve defects: a self-assembling peptide nanofiber scaffold-containing poly(lactic-co-glycolic acid) conduit. Neural Regen Res 9(24): 2132-2141.
  10. Yuan, Q., Su, H., Guo, J., Wu, W. and Lin, Z. X. (2014). Induction of phosphorylated c-Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration. J Anat 224(5): 575-582.
  11. Zhan, X., Gao, M., Jiang, Y., Zhang, W., Wong, W. M., Yuan, Q., Su, H., Kang, X., Dai, X., Zhang, W., Guo, J. and Wu, W. (2013). Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury. Nanomedicine 9(3): 305-315.
  12. Peltier, A. C., Myers, M. I., Artibee, K. J., Hamilton, A. D., Yan, Q., Guo, J., Shi, Y., Wang, L. and Li, J. (2013). Evaluation of dermal myelinated nerve fibers in diabetes mellitus. J Peripher Nerv Syst 18(2): 162-167.
  13. Li, J., Parker, B., Martyn, C., Natarajan, C. and Guo, J. (2013). The PMP22 gene and its related diseases. Mol Neurobiol 47(2): 673-698.
  14. Yan, Q., Guo, J., Zhang, X., Bai, Y., Wang, L. and Li, J. (2012). Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice. J Neurol Sci 312(1-2): 102-107.
  15. Yuan, Q., Su, H., Guo, J., Tsang, K. Y., Cheah, K. S., Chiu, K., Yang, J., Wong, W. M., So, K. F., Huang, J. D., Wu, W. and Lin, Z. X. (2012). Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush. Exp Gerontol 47(4): 329-336.
  16. Wang, C., Xie, J., Guo, J., Manning, H. C., Gore, J. C. and Guo, N. (2012). Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep 28(4): 1301-1308.
  17. Zhang, W. W., Zhan, X. D., Gao, M. Y., Hamilton, A. D., Liu, Z. Y., Jiang, Y., Su, H., Dai, X., He, B., Kang, X. N., Zeng, Y. S., Wu, W. and Guo, J. (2012). Self assembling peptide nanofiber scaffold enhanced with RhoA inhibitor CT04 improves axonal regeneration in the transected spinal cord. J Nanomaterials.
  18. Guo, J., Ma, Y. H., Yan, Q., Wang, L., Zeng, Y. S., Wu, J. L. and Li, J. (2012). Fig4 Expression in the Nervous System and Its Protection against Abnormal Lysosomal Accumulation. J Neuropathol Exp Neurol 71(1): 28-39.
  19. Su, H., Wu, Y., Yuan, Q., Guo, J., Zhang, W., Wu, W. (2011). Optimal time point for neuronal generation of transplanted neural progenitor cells in injured spinal cord following root avulsion. Cell Transplant 20(2): 167-76.
  20. Li, X., Su, H., Fu, Q. L., Guo, J., Lee, D. H., So, K. F. and Wu, W. (2011). Soluble NgR fusion protein modulates the proliferation of neural progenitor cells via the Notch pathway. Neurochem Res 36(12): 2363-2372.
  21. Katona, I., Zhang, X., Bai, Y., Shy, M. E., Guo, J., Yan, Q., Hatfield, J., Kupsky, W. J. and Li, J. (2011). Distinct pathogenic processes between Fig4-deficient motor and sensory neurons. Eur J Neurosci 33(8): 1401-1410.
  22. Guo, J., Leung, K. K., Su, H., Yuan, Q., Wang, L., Chu, T. H., Zhang, W., Pu, J. K., Ng, G. K., Wong, W. M., Dai, X. and Wu, W. (2009). Self-assembling peptide nanofiber scaffold promotes the reconstruction of acutely injured brain. Nanomedicine 5(3): 345-351.
  23. Ellis-Behnke, R. G., Liang, Y. X., Guo, J., Tay, D. K., Schneider, G. E., Teather, L. A., Wu, W. and So, K. F. (2009). Forever young: how to control the elongation, differentiation, and proliferation of cells using nanotechnology. Cell Transplant 18(9): 1047-1058.
  24. Su, H., Zhang, W., Guo, J., Guo, A., Yuan, Q. and Wu, W. (2009). Neural progenitor cells enhance the survival and axonal regeneration of injured motoneurons after transplantation into the avulsed ventral horn of adult rats. J Neurotrauma 26(1): 67-80.
  25. Su, H., Zhang, W., Guo, J., Guo, A., Yuan, Q. and Wu, W. (2009). Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor. J Neurochem 108(6): 1385-1398.
  26. Guo, J., Su, H., Zeng, Y., Liang, Y. X., Wong, W. M., Ellis-Behnke, R. G., So, K. F. and Wu, W. (2007). Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine 3(4): 311-321.
  27. Guo, J., Zeng, Y. S., Li, H. B., Huang, W. L., Liu, R. Y., Li, X. B., Ding, Y., Wu, L. Z., Cai, D. Z. (2007). Cotransplant of neural stem cells and NT-3 genetically modified Schwann cells promote the recovery transected spinal cord injury. Spinal Cord 45(1): 15-24.
  28. Guo, J., Zeng, Y., Liang, Y., Wang, L., Su, H. and Wu, W. (2007). Cyclosporine affects the proliferation and differentiation of neural stem cells in culture. Neuroreport 18(9): 863-868.
  29. Mi, S., Hu, B., Hahm, K., Luo, Y., Kam Hui, E. S., Yuan, Q., Wong, W. M., Wang, L., Su, H., Chu, T. H., Guo, J., Zhang, W., So, K. F., Pepinsky, B., Shao, Z., Graff, C., Garber, E., Jung, V., Wu, E. X. and Wu, W. (2007). LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat Med 13(10): 1228-1233.
  30. Mi, S., Hu, B., Hahm, K., Luo, Y., Hui, S. K., Yuan, Q., Wong, W. M., Wang, L., Su, H. X., Chu, T. H., Guo, J., Zhang, W. M., So, K. F., Pepinsky, B., Shao, Z. H., Graff, C., Garber, E., Jung, V., Wu, X. K. and Wu, W. (2013). Rodent EAE model for the study of axon integrity and remyelination. Nature Protocols.
  31. Zeng, Y. S., Ding, Y., Wu, L. Z., Guo, J. S., Li, H. B., Wong, W. M. and Wu, W. T. (2005). Co-transplantation of schwann cells promotes the survival and differentiation of neural stem cells transplanted into the injured spinal cord. Dev Neurosci 27(1): 20-26.
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