Giacomo Cavalli
  • Institute of Human Genetics, UMR9002 CNRS-UM, France
Research focus
  • Molecular biology
Personal information


Ph.D, ETH Zürich, Switzerland, 2000

Current position

Principal Investigator, Institute of Human Genetics, Montpellier, CNRS, France


  1. Ciabrelli, F., Comoglio, F., Fellous, S., Bonev, B., Ninova, M., Szabo, Q., Xuereb, A., Klopp, C., Aravin, A., Paro, R., Bantignies, F. and Cavalli, G. (2017). Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila. Nat Genet.
  2. Loubiere, V., Delest, A., Thomas, A., Bonev, B., Schuettengruber, B., Sati, S., Martinez, A. M. and Cavalli, G. (2016). Coordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development. Nat Genet 48(11): 1436-1442.
  3. Bonev, B. and Cavalli, G. (2016). Organization and function of the 3D genome. Nat Rev Genet 17(11): 661-678.
  4. Sexton, T. and Cavalli, G. (2015). The role of chromosome domains in shaping the functional genome. Cell 160(6): 1049-1059.
  5. Gonzalez, I., Mateos-Langerak, J., Thomas, A., Cheutin, T. and Cavalli, G. (2014). Identification of regulators of the three-dimensional polycomb organization by a microscopy-based genome-wide RNAi screen. Mol Cell 54(3): 485-499.
  6. Iovino, N., Ciabrelli, F. and Cavalli, G. (2013). PRC2 controls Drosophila oocyte cell fate by repressing cell cycle genes. Dev Cell 26(4): 431-439.
  7. Cavalli, G. (2012). Molecular biology. EZH2 goes solo. Science 338(6113): 1430-1431.
  8. Sexton, T., Yaffe, E., Kenigsberg, E., Bantignies, F., Leblanc, B., Hoichman, M., Parrinello, H., Tanay, A. and Cavalli, G. (2012). Three-dimensional folding and functional organization principles of the Drosophila genome. Cell 148(3): 458-472.
  9. Bantignies, F., Roure, V., Comet, I., Leblanc, B., Schuettengruber, B., Bonnet, J., Tixier, V., Mas, A. and Cavalli, G. (2011). Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Cell 144(2): 214-226.
  10. Schuettengruber, B., Martinez, A. M., Iovino, N. and Cavalli, G. (2011). Trithorax group proteins: switching genes on and keeping them active. Nat Rev Mol Cell Biol 12(12): 799-814.
  11. Martinez, A. M., Schuettengruber, B., Sakr, S., Janic, A., Gonzalez, C. and Cavalli, G. (2009). Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet 41(10): 1076-1082.
  12. Schuettengruber, B., Ganapathi, M., Leblanc, B., Portoso, M., Jaschek, R., Tolhuis, B., van Lohuizen, M., Tanay, A. and Cavalli, G. (2009). Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol 7(1): e13.
  13. Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B. and Cavalli, G. (2007). Genome regulation by polycomb and trithorax proteins. Cell 128(4): 735-745.
  14. Comet, I., Savitskaya, E., Schuettengruber, B., Negre, N., Lavrov, S., Parshikov, A., Juge, F., Gracheva, E., Georgiev, P. and Cavalli, G. (2006). PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Dev Cell 11(1): 117-124.
  15. Negre, N., Hennetin, J., Sun, L. V., Lavrov, S., Bellis, M., White, K. P. and Cavalli, G. (2006). Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol 4(6): e170.
  16. Grimaud, C., Bantignies, F., Pal-Bhadra, M., Ghana, P., Bhadra, U. and Cavalli, G. (2006). RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124(5): 957-971.
  17. Martinez, A. M., Colomb, S., Dejardin, J., Bantignies, F. and Cavalli, G. (2006). Polycomb group-dependent Cyclin A repression in Drosophila. Genes Dev 20(4): 501-513.
  18. Dejardin, J., Rappailles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D. and Cavalli, G. (2005). Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature 434(7032): 533-538.
  19. Bantignies, F., Grimaud, C., Lavrov, S., Gabut, M. and Cavalli, G. (2003). Inheritance of Polycomb-dependent chromosomal interactions in Drosophila. Genes Dev 17(19): 2406-2420.
  20. Cavalli, G. and Paro, R. (1999). Epigenetic inheritance of active chromatin after removal of the main transactivator. Science 286(5441): 955-958.
  21. Cavalli, G. and Paro, R. (1998). The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell 93(4): 505-518.
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