Holger Bierhoff
  • Department of Biochemistry, Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine (CMB), Friedrich Schiller University Jena, Germany
Research fields
  • Cancer biology
Personal information


Ph.D, German Cancer Research Center, Heidelberg, Germany, 2007

Current position

Group leader, Center for Molecular Biomedicine (CMB), Friedrich Schiller University Jena, Germany


  1. Schnoder, T. M., Eberhardt, J., Koehler, M., Bierhoff, H. B., Weinert, S., Pandey, A. D., Nimmagadda, S. C., Wolleschak, D., Johrens, K., Fischer, T. and Heidel, F. H. (2017). Cell autonomous expression of CXCL-10 in JAK2V617F-mutated MPN. J Cancer Res Clin Oncol 143(5): 807-820.
  2. Zhao, Z., Dammert, M. A., Hoppe, S., Bierhoff, H. and Grummt, I. (2016). Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucleic Acids Res 44(17): 8144-8152.
  3. Zhao, Z., Dammert, M. A., Grummt, I. and Bierhoff, H. (2016). lncRNA-Induced Nucleosome Repositioning Reinforces Transcriptional Repression of rRNA Genes upon Hypotonic Stress. Cell Rep 14(8): 1876-1882.
  4. Parlato, R., and Bierhoff, H. (2015). Role of nucleolar dysfunction in neurodegenerative disorders: a game of genes? AIMS Mol Sci 2: 211-224.
  5. Bierhoff, H., Dammert, M. A., Brocks, D., Dambacher, S., Schotta, G. and Grummt, I. (2014). Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing. Mol Cell 54(4): 675-682.
  6. Bierhoff, H., Postepska-Igielska, A. and Grummt, I. (2014). Noisy silence: non-coding RNA and heterochromatin formation at repetitive elements. Epigenetics 9(1): 53-61.
  7. Kiryk, A., Sowodniok, K., Kreiner, G., Rodriguez-Parkitna, J., Sonmez, A., Gorkiewicz, T., Bierhoff, H., Wawrzyniak, M., Janusz, A. K., Liss, B., Konopka, W., Schutz, G., Kaczmarek, L. and Parlato, R. (2013). Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Front Cell Neurosci 7: 207.
  8. Kreiner, G., Bierhoff, H., Armentano, M., Rodriguez-Parkitna, J., Sowodniok, K., Naranjo, J. R., Bonfanti, L., Liss, B., Schutz, G., Grummt, I. and Parlato, R. (2013). A neuroprotective phase precedes striatal degeneration upon nucleolar stress. Cell Death Differ 20(11): 1455-1464.
  9. Bierhoff, H., Schmitz, K., Maass, F., Ye, J. and Grummt, I. (2010). Noncoding transcripts in sense and antisense orientation regulate the epigenetic state of ribosomal RNA genes. Cold Spring Harb Symp Quant Biol 75: 357-364.
  10. Hoppe, S., Bierhoff, H., Cado, I., Weber, A., Tiebe, M., Grummt, I. and Voit, R. (2009). AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply. Proc Natl Acad Sci U S A 106(42): 17781-17786.
  11. Bierhoff, H., Dundr, M., Michels, A. A. and Grummt, I. (2008). Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I. Mol Cell Biol 28(16): 4988-4998.
  12. Mayer, C., Bierhoff, H. and Grummt, I. (2005). The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis. Genes Dev 19(8): 933-941.
  13. Arabi, A., Wu, S., Ridderstrale, K., Bierhoff, H., Shiue, C., Fatyol, K., Fahlen, S., Hydbring, P., Soderberg, O., Grummt, I., Larsson, L. G. and Wright, A. P. (2005). c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription. Nat Cell Biol 7(3): 303-310.
  14. Pawlowski, A., Riedel, K. U., Klipp, W., Dreiskemper, P., Gross, S., Bierhoff, H., Drepper, T. and Masepohl, B. (2003). Yeast two-hybrid studies on interaction of proteins involved in regulation of nitrogen fixation in the phototrophic bacterium Rhodobacter capsulatus. J Bacteriol 185(17): 5240-5247.
We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.