Fariba Behbod Department of Pathology and Laboratory Medicine, University of Kansas Medical School, USA
3 protocols

Daniel Medina Department of Cell Biology, Baylor College of Medicine, USA
3 protocols

Frances Kittrell Department of Cell Biology, Baylor College of Medicine, USA
3 protocols

Yan Hong Department of Pathology and Laboratory Medicine, University of Kansas Medical School, USA
3 protocols

David Edwards
  • Department of Cell Biology, Baylor College of Medicine, USA
Research focus
  • Cancer biology
  • 1 Author merit


B.S, University of Alabama at Birmingham, 1992

Current position

Research Associate, Dept. of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX


  1. Zheng, Z. Y., Tian, L., Bu, W., Fan, C., Gao, X., Wang, H., Liao, Y. H., Li, Y., Lewis, M. T., Edwards, D., Zwaka, T. P., Hilsenbeck, S. G., Medina, D., Perou, C. M., Creighton, C. J., Zhang, X. H. and Chang, E. C. (2015). Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep 12(3): 511-524.
  2. Dasgupta, A., Edwards, D., Kittrell, F. S., Hilsenbeck, S. G., Medina, D. and Jiralerspong, S. (2015). Metformin for the treatment of ductal carcinoma in situ (DCIS). Cancer Res 75(9): P6-13-04.
  3. Mukherjee, M., Ge, G., Rao, P. H., Zhang, N., Edwards, D., Sharan, S., Medina, D. and Pati, D. (2013). Aneuploidy is necessary but not sufficient for tumorigenesis. Oncogene 33(48).
  4. Machado, H. L., Kittrell, F. S., Edwards, D., White, A. N., Atkinson, R. L., Rosen, J. M., Medina, D. and Lewis, M. T. (2013). Separation by cell size enriches for mammary stem cell repopulation activity. Stem Cells Transl Med 2(3): 199-203.
  5. Mazumdar, A., Medina, D., Kittrell, F. S., Zhang, Y., Hill, J. L., Edwards, D. E., Bissonnette, R. P. and Brown, P. H. (2012). The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice. Cancer Prev Res (Phila) 5(10): 1195-1202.
  6. Medina, D., Edwards, D. G., Kittrell, F., Lee, S. and Allred, D. C. (2012). Intra-mammary ductal transplantation: a tool to study premalignant progression. J Mammary Gland Biol Neoplasia 17(2): 131-133.
  7. Oesterreich, S., Kitchens, C., Gavin, P., Wu, C. C., Riehle, K., Coarfa, C., Edwards, D., Schiff, R., Milosavljevic, A. and Lee, A. (2012). Lack of Frequent Estrogen Receptor Mutation in Primary Breast Tumors. Cancer Res 72(24): P6-05-12.
  8. Herschkowitz, J. I., Zhao, W., Zhang, M., Usary, J., Murrow, G., Edwards, D., Knezevic, J., Greene, S. B., Darr, D., Troester, M. A., Hilsenbeck, S. G., Medina, D., Perou, C. M. and Rosen, J. M. (2012). Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A 109(8): 2778-2783.
  9. Herschkowitz, J. I., Zhang, M., Zhaow, W., Murrow, G. W., Edwards, D., Knezevic, J., Greene, S. B., Medina, D., Perou, C. M. and Rosen, J. M. (2011). p53 null spindloid murine mammary tumors show features associated with human claudin-low tumors and enrichment for cancer stem cells. Cancer Res 70(8): 4212-4212.
  10. Behbod, F., Kittrell, F. S., LaMarca, H., Edwards, D., Kerbawy, S., Heestand, J. C., Young, E., Mukhopadhyay, P., Yeh, H. W., Allred, D. C., Hu, M., Polyak, K., Rosen, J. M. and Medina, D. (2009). An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res 11(5): R66.
  11. Zhang, M., Behbod, F., Atkinson, R. L., Landis, M. D., Kittrell, F., Edwards, D., Medina, D., Tsimelzon, A., Hilsenbeck, S., Green, J. E., Michalowska, A. M. and Rosen, J. M. (2008). Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 68(12): 4674-4682.
  12. Gatza, C. E., Dumble, M., Kittrell, F., Edwards, D. G., Dearth, R. K., Lee, A. V., Xu, J., Medina, D. and Donehower, L. A. (2008). Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol 313(1): 130-141.
  13. Loehberg, C. R., Thompson, T., Kastan, M. B., Edwards, D. G., Kittrell, F. S., Medina, D., Conneely, O. M. and O'Malley, B. W. (2007). ATM and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res 67:12026-12033.
  14. Goepfert, T. M., Moreno-Smith, M., Edwards, D. G., Pathak, S., Medina, D. and Brinkley, W. R. (2007). Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer 120(5): 985-994.
  15. Keaton, A. K., White, R. and Berecek, K. H. (1998). The effects of long-term captopril treatment and its withdrawal on acetylcholine-induced relaxation in the spontaneously hypertensive rat. Clin. and Exper. Hypertension 20(8): 847-866.
  16. Regan, C. P., Bishop, S. P. and Berecek, K. H. (1997). Early, short-term treatment with captopril permanently attenuates cardiovascular changes in spontaneously hypertensive rats. Clin Exp Hypertens 19(8): 1161-1177.
  17. Regan, C. P., Anderson, P. G., Bishop, S. P. and Berecek, K. H. (1997). Pressure-independent effects of AT1-receptor antagonism on cardiovascular remodeling in aortic-banded rats. Am J Physiol 272(5 Pt 2): H2131-2138.
  18. Regan, C. P., Anderson, P. G., Bishop, S. P. and Berecek, K. H. (1996). Captopril prevents vascular and fibrotic changes but not cardiac hypertrophy in aortic-banded rats. Am J Physiol 271(3 Pt 2): H906-913.
  19. Zhang, L., Edwards, D. G. and Berecek, K. H. (1996). Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY). Clin Exp Hypertens 18(2): 201-226.
  20. Berecek, K. H., Edwards, D., Wu, J. N. (1994). Alterations in brain angiotensin-II (AII) binding in brains and primary neuronal cultures (PNC) from captopril (CAP) treated spontaneous hypertensive rats (SHR). The FASEB Journal 8(4): A5-A5.
  21. Wu, J. N., Edwards, D. G., Zhang, L. and Berecek, K. H. (1994). Effects of early treatment of spontaneously hypertensive rats with an angiotensin converting enzyme inhibitor on blood pressure, baroreflex function and cardiac hypertrophy. Hypertension  Res: Clinical & Exper 17: 243-251.
  22. Wu, J. N., Edwards, D. and Berecek, K. H. (1994). Changes in renal angiotensin II receptors in spontaneously hypertensive rats by early treatment with the angiotensin-converting enzyme inhibitor captopril. Hypertension 23(6 Pt 2): 819-822.
  23. Berecek, K. H., Wu, J. N. and Edwards, D. (1993). Alterations in renal angiotensin-II (AII) receptor-binding in captopril (CAP) treated spontaneously hypertensive rats (SHR). Hypertension 22(3): 409-409.
1 Protocol published
Pituitary Isograft Transplantation in Mice
Authors:  Chance Walker, Yan Hong, Frances Kittrell, Daniel Medina, David Edwards and Fariba Behbod, date: 06/05/2017, view: 7181, Q&A: 0
The mouse pituitary isograft is a technique developed to administer persistent hormone stimulation, thereby increasing cellular proliferation in the mammary tissue (Christov et al., 1993). The pituitary isograft procedure was first ...
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