Musa Mhlanga IDM, University of Cape Town, Cape Town
1 protocol

Sipho Mamputha Sipho Mamputha
1 protocol

Stoyan Stoychev 1 protocol
Andrea Puhar MIMS and Department of Molecular Biology, Umeå University
57 protocols

Cristina Suárez Twist Bioscience
5 protocols

Dhruv Patel Oligomerix, Inc.
3 protocols

Doyel Sen E-Scape Bio Inc
4 protocols

Reviewer
Anca Flavia Savulescu
  • Senior Researcher, University of Cape Town
Research focus
  • Biochemistry
  • 1 Author merit

Education

PhD, Technion, 2011

Publications

Cohen B.,* Golani, A.,* Altman, T.,* Savulescu, A.F., Perlson, E., Arava, Y. Mitochondria shuttles mRNAs along axons in a co-translational manner. *These authors contributed equally to this work. Journal of Cell Science, 2022, Jul 14;jcs.259436

Bouilhol, E., Savulescu, A.F., Le Fevre, E., Dartigues, B., Brackin, R., Nikolski, M. DeepSpot: a deep neural network for mRNA spots. Biological Imaging, 2022 Volume 2, 2022, e4, doi.org/10.1017/S2633903X22000034

Savulescu, A.F.*, Beaume Nicolas, Bouilhol, E., Nikolski, M*. Prediction of RNA subcellular localization: learning from heterogeneous data sources. iScience 2021 Nov 24 .*corresponding author

Savulescu, A.F.*, Brackin, R., Bouihol, E., Dartigues, B., Warrell, H.J., Pimentel, M.R., Dallongeville, S.,Schmoranzer, J., Olivo-Marin, J.C., Gomes, E.R., Nikolski M., and Mhlanga, M.M#. Interrogating RNA and Protein Spatial Subcellular Distribution in smFISH data with DypFISH. Cell Reports Methods, 2021, Sep13;1(5):100068, *corresponding author

Jones, K., Savulescu, A.F., Brombacher, F., Hadebe, S. IgM in health and diseases: How far have we come and what next? Front Immunol 2020 Oct 30;11:595535

Savulescu, A.F.*, Jacobs, C., Davignon, L., Negishi, Y., Mhlanga M.M. Pintpointing Cell Identity in Time and Space. Front. Mol. Biosci., 2020 Aug 14;7:209. *corresponding author

Savulescu, A.F.*,#, Stoychev., S.*, Mamputha, S., Mhlanga, M.M. Biochemical pulldown of mRNAs and long noncoding RNAs from cellular lysates coupled with mass spectrometry to identify protein binding partners. *These authors contributed equally. Bio-Protocol, 2020, 10(11):e3639 #corresponding author

Scholefield, J. *, Henriques, R. *, Savulescu A.F., Fontan, E., Boucharlat, A., Laplantine, E., Smahi, A.,Israel, A., Agou, F. and Mhlanga, M.M. Super resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti. * These authors contributed equally. Nature Communications, 2016 Sep 2;7:12629

Anderson, F.*, Savulescu, A.F.*, Rudolph, K., Rotem, A., Schipke, J., Ibiricu, I., Cohen, I., Gruenwald, K., Sodeik, B.± and Harel, A.±. Targeting of Viral Capsids to Nuclear Pores in a Cell-free Reconstitution System. (*/± these authors contributed equally) Traffic, 2014 Aug 18.

Naidoo, J., Brackin, R., Khutlang, R., Savulescu, A.F. and Mhlanga, M.M. Applied RNAi: From Fundamental Research to Therapeutic Applications Book, Chapter 5 – Systems Biology Tools to Understand the Role of Host miRNAs in Infection: A Closer Look at HIV. June 2014

Weberruss, M.H., Savulescu, A.F., Jando, J., Bissinger, T., Harel, A., Glickman, M.H. and Enenkel, C. Blm10 facilitates nuclear import of proteasome core particles. EMBO J., 2013 Aug 27

Savulescu, A.F., Rotem, A. and Harel, A. Proteasomes crossing the Nuclear Border. Nucleus, 2011 Jul 1:2(4)

Savulescu, A.F. and Glickman, M.H. The HEAT is on. Molecular & Cellular Proteomics, 2011 Mar 9.

Savulescu, A.F., Shorer, H., Kleifeld, O., Cohen, I., Glickman, M.H. and Harel, A. Nuclear import of an intact preassembled proteasome particle. Molecular Biology of the Cell, 2011 Mar; 22(6):880-91 (spotlighted by Highlights from MBoC, March 2011, and Research Highlights in Nature Rev. Mol. Cell Biol. 12: 139, March 2011).
1 Protocol published
Biochemical Pulldown of mRNAs and Long Noncoding RNAs from Cellular Lysates Coupled with Mass Spectrometry to Identify Protein Binding Partners
Authors:  Anca F. Savulescu, Stoyan Stoychev, Sipho Mamputha and Musa M. Mhlanga, date: 06/05/2020, view: 4614, Q&A: 2
RNA binding proteins (RBPs) interact with cellular mRNAs, controlling various steps throughout the lifetime of these transcripts, including transcription, cellular transport, subcellular localization, translation and degradation. In addition to ...
24 Protocols reviewed
Collection of in vivo Capacitated Sperm from Different Locations Along the Reproductive Tract of Time-Mated Female Mice by Microdissection
Authors:  Lukas Ded and Jean-Ju Chung, date: 10/20/2021, view: 1895, Q&A: 0

Mammalian sperm cells are not capable of fertilizing an egg immediately after ejaculation; instead, they must gradually acquire the capacity to fertilize while they travel inside the female reproductive tract. Sperm cells are transported by the

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Electron Tomography to Study the Three-dimensional Structure of the Reovirus Egress Pathway in Mammalian Cells

Mammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that replicate and assemble in cytoplasmic membranous organelles called viral inclusions (VIs). To define the cellular compartments involved in nonlytic reovirus

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