Gilbert Vassart
  • Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Faculty of Medicine, Université Libre de Bruxelles ULB, Belgium
Research focus
  • Stem cell
Personal information


Ph.D in Free University of Brussels, 1974

Current Position

Institut de Recherche Interdisciplinaire en Biologie Humaine Moléculaire, Université Libre de Bruxelles, Belgium


  1. Zoenen, M., Urizar, E., Swillens, S., Vassart, G. and Costagliola, S. (2012). Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers. Nat Commun 3: 1007.
  2. Vassart, G. and Costagliola, S. (2011). G protein-coupled receptors: mutations and endocrine diseases. Nat Rev Endocrinol 7(6): 362-372.
  3. Mustata, R. C., Van Loy, T., Lefort, A., Libert, F., Strollo, S., Vassart, G. and Garcia, M. I. (2011). Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo. EMBO Rep 12(6): 558-564.
  4. Garcia, M. I., Ghiani, M., Lefort, A., Libert, F., Strollo, S. and Vassart, G. (2009). LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine. Dev Biol 331(1): 58-67.
  5. Decaux, G., Soupart, A. and Vassart, G. (2008). Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet 371(9624): 1624-1632.
  6. Urizar, E., Montanelli, L., Loy, T., Bonomi, M., Swillens, S., Gales, C., Bouvier, M., Smits, G., Vassart, G. and Costagliola, S. (2005). Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO J 24(11): 1954-1964.
  7. Ledent, C., Demeestere, I., Blum, D., Petermans, J., Hamalainen, T., Smits, G. and Vassart, G. (2005). Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci U S A 102(25): 8922-8926.
  8. Smits, G., Campillo, M., Govaerts, C., Janssens, V., Richter, C., Vassart, G., Pardo, L. and Costagliola, S. (2003). Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity. EMBO J 22(11): 2692-2703.
  9. Smits, G., Olatunbosun, O., Delbaere, A., Pierson, R., Vassart, G. and Costagliola, S. (2003). Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. N Engl J Med 349(8): 760-766.
  10. Rodien, P., Bremont, C., Sanson, M. L., Parma, J., Van Sande, J., Costagliola, S., Luton, J. P., Vassart, G. and Duprez, L. (1998). Familial gestational hyperthyroidism caused by a mutant thyrotropin receptor hypersensitive to human chorionic gonadotropin. N Engl J Med 339(25): 1823-1826.
  11. Ledent, C., Vaugeois, J. M., Schiffmann, S. N., Pedrazzini, T., El Yacoubi, M., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G. and Parmentier, M. (1997). Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388(6643): 674-678.
  12. Abramowicz, M. J., Duprez, L., Parma, J., Vassart, G. and Heinrichs, C. (1997). Familial congenital hypothyroidism due to inactivating mutation of the thyrotropin receptor causing profound hypoplasia of the thyroid gland. J Clin Invest 99(12): 3018-3024.
  13. Samson, M., Libert, F., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C. M., Saragosti, S., Lapoumeroulie, C., Cognaux, J., Forceille, C., Muyldermans, G., Verhofstede, C., Burtonboy, G., Georges, M., Imai, T., Rana, S., Yi, Y., Smyth, R. J., Collman, R. G., Doms, R. W., Vassart, G. and Parmentier, M. (1996). Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382(6593): 722-725.
  14. Kopp, P., van Sande, J., Parma, J., Duprez, L., Gerber, H., Joss, E., Jameson, J. L., Dumont, J. E. and Vassart, G. (1995). Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene. N Engl J Med 332(3): 150-154.
  15. Duprez, L., Parma, J., Van Sande, J., Allgeier, A., Leclere, J., Schvartz, C., Delisle, M. J., Decoulx, M., Orgiazzi, J., Dumont, J. and et al. (1994). Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism. Nat Genet 7(3): 396-401.
  16. Parma, J., Duprez, L., Van Sande, J., Cochaux, P., Gervy, C., Mockel, J., Dumont, J. and Vassart, G. (1993). Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365(6447): 649-651.
  17. Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggerickx, D., Ledent, C., Mollereau, C., Gerard, C., Perret, J. and et al. (1992). Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature 355(6359): 453-455.
  18. Abramowicz, M. J., Targovnik, H. M., Varela, V., Cochaux, P., Krawiec, L., Pisarev, M. A., Propato, F. V., Juvenal, G., Chester, H. A. and Vassart, G. (1992). Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter. J Clin Invest 90(4): 1200-1204.
  19. Ieiri, T., Cochaux, P., Targovnik, H. M., Suzuki, M., Shimoda, S., Perret, J. and Vassart, G. (1991). A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. J Clin Invest 88(6): 1901-1905.
  20. Libert, F., Schiffmann, S. N., Lefort, A., Parmentier, M., Gerard, C., Dumont, J. E., Vanderhaeghen, J. J. and Vassart, G. (1991). The orphan receptor cDNA RDC7 encodes an A1 adenosine receptor. EMBO J 10(7): 1677-1682.
  21. Libert, F., Parmentier, M., Lefort, A., Dinsart, C., Van Sande, J., Maenhaut, C., Simons, M. J., Dumont, J. E. and Vassart, G. (1989). Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science 244(4904): 569-572.
  22. Vassart, G., Georges, M., Monsieur, R., Brocas, H., Lequarre, A. S. and Christophe, D. (1987). A sequence in M13 phage detects hypervariable minisatellites in human and animal DNA. Science 235(4789): 683-684.
  23. Libert, F., Ruel, J., Ludgate, M., Swillens, S., Alexander, N., Vassart, G. and Dinsart, C. (1987). Thyroperoxidase, an auto-antigen with a mosaic structure made of nuclear and mitochondrial gene modules. EMBO J 6(13): 4193-4196.
  24. Ricketts, M. H., Pohl, V., de Martynoff, G., Boyd, C. D., Bester, A. J., Van Jaarsveld, P. P. and Vassart, G. (1985). Defective splicing of thyroglobulin gene transcripts in the congenital goitre of the Afrikander cattle. EMBO J 4(3): 731-737.
  25. Mercken, L., Simons, M. J., Swillens, S., Massaer, M. and Vassart, G. (1985). Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA. Nature 316(6029): 647-651.
  26. Vassart, G., Refetoff, S., Brocas, H., Dinsart, C. and Dumont, J. E. (1975). Translation of thyroglobulin 33S messenger RNA as a means of determining thyroglobulin quaternary structure. Proc Natl Acad Sci U S A 72(10): 3839-3843.
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