Education
Ph.D. in Department of Cell Physiology and Pharmacology, University of Leicester, 2005
Current Position
Senior Post-Doctoral Research Fellow, University of Warwick, 2014
Publications
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Muter, J., Brighton, P. J., Lucas, E. S., Lacey, L., Shmygol, A., Quenby, S., Blanks, A. M. and Brosens, J. J. (2016). Progesterone-Dependent Induction of Phospholipase C-Related Catalytically Inactive Protein 1 (PRIP-1) in Decidualizing Human Endometrial Stromal Cells. Endocrinology 157(7): 2883-2893.
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Lucas, E. S., Dyer, N. P., Murakami, K., Lee, Y. H., Chan, Y. W., Grimaldi, G., Muter, J., Brighton, P. J., Moore, J. D., Patel, G., Chan, J. K., Takeda, S., Lam, E. W., Quenby, S., Ott, S. and Brosens, J. J. (2016). Loss of Endometrial Plasticity in Recurrent Pregnancy Loss. Stem Cells 34(2): 346-356.
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Willets, J. M., Brighton, P. J., Windell, L. N., Rana, S., Nash, C. A. and Konje, J. C. (2015). Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins. Mol Cell Endocrinol 407: 57-66.
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Muter, J., Lucas, E. S., Chan, Y. W., Brighton, P. J., Moore, J. D., Lacey, L., Quenby, S., Lam, E. W. and Brosens, J. J. (2015). The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. FASEB J 29(4): 1603-1614.
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Tovey, S. C., Brighton, P. J., Bampton, E. T., Huang, Y. and Willars, G. B. (2013). Confocal microscopy: theory and applications for cellular signaling. Methods Mol Biol 937: 51-93.
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Morris, G. E., Nelson, C. P., Brighton, P. J., Standen, N. B., Challiss, R. A. and Willets, J. M. (2012). Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle. Am J Physiol Cell Physiol 302(5): C723-734.
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Brighton, P. J., Marczylo, T. H., Rana, S., Konje, J. C. and Willets, J. M. (2011). Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium. Br J Pharmacol 164(5): 1479-1494.
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Brighton, P. J., Rana, S., Challiss, R. J., Konje, J. C. and Willets, J. M. (2011). Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells. Br J Pharmacol 162(7): 1603-1617.
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Morris, G. E., Nelson, C. P., Everitt, D., Brighton, P. J., Standen, N. B., Challiss, R. A. and Willets, J. M. (2011). G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Cardiovasc Res 89(1): 193-203.
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Brighton, P. J., McDonald, J., Taylor, A. H., Challiss, R. A., Lambert, D. G., Konje, J. C. and Willets, J. M. (2009). Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells. Mol Endocrinol 23(9): 1415-1427.
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Willets, J. M., Brighton, P. J., Mistry, R., Morris, G. E., Konje, J. C. and Challiss, R. A. (2009). Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle. Mol Endocrinol 23(8): 1272-1280.
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Kakaoula, K., Tovey, S. C., Brighton, P. J. and Willars, G. B. (2008). Lack of receptor selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and GnRH-receptor-mediated signalling through Gαq/11. Eur J Pharmacol 587(1-3): 16-24.
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Brighton, P. J., Wise, A., Dass, N. B. and Willars, G. B. (2008). Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue. J Pharmacol Exp Ther 325(1): 154-164.
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Tovey, S. C., Brighton, P. J. and Willars, G. B. (2006). Confocal microscopy: theory and applications for cellular signaling. Methods Mol Biol 312: 57-85.
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Brighton, P. J., Szekeres, P. G., Wise, A. and Willars, G. B. (2004). Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction. Mol Pharmacol 66(6): 1544-1556.
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Brighton, P. J., Szekeres, P. G. and Willars, G. B. (2004). Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56(2): 231-248.